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ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating pi3k/akt/mtor signaling

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Oncology Research 2024年第7期32卷 1209-1219页

作者： XIA DA HAN GE JUNFENG SHI CHUNHUA ZHU GUOZHU WANG YUAN FANG JIN XU Department of Breast and Thyroid Nanjing First HospitalNanjing Medical UniversityNanjingChina Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Oncology Nanjing First HospitalNanjing Medical UniversityNanjingChina Department of Pathology Nanjing First HospitalNanjing Medical UniversityNanjingChina

Objective:This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2(ROR2)in triple-negative breast cancer(TNBC).Methods:ROR2 expression in primary TNBC and metastatic TNBC tissues was analyzed by immunohistochemical staining and ***2 expression in TNBC cell lines was detected by PCR and Western blot *** migration,invasion and chemosensitivity of TNBC cells with overexpression or knockdown of ROR2 were ***:ROR2 expression was high in metastatic TNBC ***2 knockdown suppressed the migration,invasion and chemoresistance of TNBC ***2 overexpression in MDA-MB-435 cells promoted the migration,invasion,and ***,ROR2 knockdown in HC1599 and MDA-MB-435 adriamycin-resistant cells enhanced chemosensitivity to ***2 could activate pi3k/akt/mtor signaling in TNBC ***:ROR2 is upregulated and promotes metastatic phenotypes of TNBC by activating pi3k/akt/mtor signaling.

关键词： Receptor tyrosine kinase-like orphan receptor 2 Triplet-negative breast cancer Proliferation Apoptosis pi3k/akt/mtor signaling Metastasis

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MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and pi3k/akt/mtor signaling

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2170-2182页

作者： Xiao-Jing Gu Ya-Jun Li Fang Wang Ting Ye Department of Gastroenterology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous PrefectureChina

BACkGROUND Gastric cancer(GC)is a common type of digestive cancer with high morbidity and mortality rates *** effort has been expended in understanding the mechanism of GC development and *** current study therefore explores the involvement of microRNAs in the regulation of GC *** To explore the expression and function of miR-30e-3p in GC *** MiR-30e-3p was found to be downregulated in GC,with low levels thereof predicting poor outcomes among patients with ***,we revealed that miR-30e-3p suppressed cell growth and metastatic behaviors of GC *** analysis predicted that THO complex 2(THOC2)was a direct target of miR-30e-3p,and the interaction between miR-30e-3p and THOC2 was further validated by a luciferase reporter *** Our findings revealed that knockdown of THOC2 inhibited the growth and metastatic behaviors of GC *** investigating signaling pathways involved in miR-30e-3p regulation,we found that the miR-30e-3p/THOC2 axis regulated the pi3k/akt/mtor pathway in *** Our findings suggest the novel functional axis miR-30e-3p/THOC2 is involved in GC development and *** miR-30e-3p/THOC2 axis could be utilized to develop new therapies against GC.

关键词： Gastric cancer MiR-30e-3p THO complex2 pi3k/akt/mtor signaling

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Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

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Cancer Communications 2021年第12期41卷 1275-1313页

作者： Valdenizia R.Silva Luciano de S.Santos Rosane B.Dias Claudio A.Quadros Daniel P.Bezerra Gonçalo Moniz Institute Oswaldo Cruz Foundation(IGM-FIOCRUZ/BA)SalvadorBahia 40296-710Brazil São Rafael Hospital Rede D’Or/São LuizSalvadorBahia 41253-190Brazil Bahia State University SalvadorBahia 41150-000Brazil

Colorectal cancer(CRC)represents the third most commonly diagnosed cancer and the second leading cause of cancer death *** modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells(CSCs),which present both pluripotency and self-renewal *** cells are considered responsible for the progression of the disease,recurrence and tumor ***,some cell signaling pathways participate in CRC survival,proliferation,and selfrenewal properties,and most of them are dysregulated in CSCs,including the Wingless(Wnt)/β-catenin,Notch,Hedgehog,nuclear factor kappa B(NF-κB),Janus kinase/signal transducer and activator of transcription(JAk/STAT),peroxisome proliferator-activated receptor(PPAR),phosphatidyl-inositol-3-kinase/akt/mechanistic target of rapamycin(pi3k/akt/mtor),and transforming growth factor-β(TGF-β)/Smad *** this review,we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways,which will contribute to the study of potential therapeutic schemes,combining conventional drugs with CSC-targeting drugs,and allowing better cure rates in anti-CRC therapy.

关键词： colorectal cancer stem cells cell signaling Wnt/β-catenin pathway Notch Hedgehog NF-κB JAk/STAT signaling pi3k/akt/mtor signaling targeted therapy

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