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Absolute Lymphocyte/Monocyte Ratio at Diagnosis and Interim Positron-Emission Tomography Predict Survival in Classical Hodgkin Lymphoma

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Journal of Cancer Therapy 2013年第3期4卷 452-459页

作者： Luis F. Porrata Kay M. Ristow Thomas M. Habermann Thomas E. Witzig Joseph P. Colgan David J. Inwards Stephen M. Ansell Ivana N. Micallef Patrick B. Johnston Grzegorz Nowakowski Carrie A. Thompson Svetomir N. Markovic Division of Hematology Internal Medicine Mayo College of Medicine Rochester USA

Interim Positron-Emission Tomography (int-pet) and the peripheral blood absolute lymphocyte/monocyte ratio at di- agnosis (ALC/AMC-DX) have been shown to be predictors for progression-free survival (PFS) and time to progression (TTP) in classical Hodgkin lymphoma (cHL). Therefore, we studied if the combination of ALC/AMC-DX and the (int-pet) can further stratified PFS and TTP in cHL patients. Patients were required to be diagnosed, treated, and followed with int-pet at Mayo Clinic, Rochester, Minnesota. From 2000 until 2008, 111 cHL patients qualified for the study. The median follow-up was 2.8 years (range: 0.3 - 10.4 years). Patients with a negative int-pet (N = 98) pre- sented with a higher ALC/AMC-DX (median of 2.32, range: 0.26 - 37.5) compared with patients with a positive int-pet (N = 13) (median of 0.9, range: 0.29 - 3.10), p 1.1. Group 1 experienced superior PFS and TTP in comparison with the other groups. In conclusion, the combination of ALC/AMC-DX and the int-pet provides a simple model to assess clinical outcomes in cHL.

关键词： Classical Hodgkin Lymphoma Absolute Lymphocyte/Monocyte Ratio at Diagnosis Interim pet-scan Progression-Free Survival Time to Progression

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Contribution of Metabolic Imaging in the Exploration of Cognitive Disorders Related to COVID-19

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Advances in Molecular Imaging 2024年第1期13卷 1-5页

作者： Serigne Moussa Badiane Amadou Barro Elhadji Amadou Lamine Bathily Louis Augustin Diaga Diouf Biophysics and Nuclear Medicine Gaston Berger University Saint-Louis Senegal ENT Department Fann University Hospital Dakar Senegal Biophysics and Nuclear Medicine Cheikh Anta Diop University Dakar Senegal

On March 11, 2019, the WHO declared COVID-19 a pandemic disease. It is a respiratory tropism SARS COV 2 infection. In the emergency of the pandemic, in medical imaging, only computed tomography (CT) of the lungs was favored to assess lung lesions. In addition, many cases of post-COVID-19 cognitive disorders have been reported. As the curve dips and services restart correctly, other imaging techniques have been used to better explore the disease. The objective of this presentation is to illustrate the contribution of metabolic imaging in the exploration of post COVID-19 cognitive disorders and to discuss the pathophysiological mechanisms. Hypometabolism brain lesions are objective signs of functional impairment whose pathophysiological mechanism is not yet fully understood. Metabolic imaging with pet-scan is a suitable tool for exploring these disorders, both for the severity and extent of the lesions and for the topography of the brain damage.

关键词： COVID-19 Nuclear Medicine Cognitive Disorders pet-scan

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Primary Malignant Parotid Melanoma: Searching for a Rare Entity

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第5期3卷 228-232页

作者： Ithzel Maria Villarreal Beatriz Arellano Jeanette Sáenz Luz Martin José Ramón Castello José Ramón García-Berrocal Department of ENT “Puerta de Hierro-Majadahonda” University Hospital Madrid Spain Department of Pathology “Puerta de Hierro-Majadahonda” University Hospital Madrid Spain Department of Plastic Surgery “Puerta de Hierro-Majadahonda” University Hospital Madrid Spain

Objectives: The aim of this paper is to establish a correct approach to the diagnosis of a primary malignant melanoma of the parotid gland. Methods: We present a case of a patient with a painless mass situated in the left parotid region after an initial cytological and radiological study suggesting a Warthin tumor whose treatment involved a total parotidectomy with a facial nerve reconstruction. Results: The histopathological result showed a malignant melanoma that after various studies and evaluations showed no other primary origin different from the parotid gland itself. Conclusions: Salivary gland melanomas are relatively rare entities that when being of a primary origin and localized in the parotid gland become even more uncommon. Upon a melanoma found in the parotid gland, the first suspicion should be a metastatic origin, being the most common sites the oral cavity and the skin from the head and neck region.

关键词： Primary Parotid Melanoma pet-scan S100 Protein Facial Nerve Reconstruction

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