检索结果-南通市图书馆

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols(pegs) with particular reference to P-glycoprotein

引用

Acta Pharmaceutica Sinica B 2020年第10期10卷 2002-2009页

作者： Tingting Wang Yingjie Guo Yang He Tianming Ren Lei Yin John Paul Fawcett Jingkai Gu Huimin Sun Clinical Laboratory First HospitalJilin UniversityChangchun 130061China Research Institute of Translational Medicine First HospitalJilin UniversityChangchun 130061China Research Center for Drug Metabolism College of Life ScienceJilin UniversityChangchun 130012China Department of Pharmaceutical Sciences and Experimental Therapeutics College of PharmacyUniversity of IowaIowa City IA 52242USA Beijing Institute of Drug Metabolism Beijing 102209China National Institutes for Food and Drug Control Beijing 100050China

Polyethylene glycols(pegs)in general use are polydisperse molecules with molecular weight(MW)distributed around an average value applied in their designation e.g.,PEG *** research has shown that pegs can act as P-glycoprotein(P-gp)inhibitors with the potential to affect the absorption and efflux of concomitantly administered ***,questions related to the mechanism of cellular uptake of pegs and the exact role played by P-gp has not been *** this study,we examined the mechanism of uptake of pegs by MDCK-mock cells,in particular,the effect of MW and interaction with P-gp by MDCK-hMDRl and A549 *** results show that:(a)the uptake of pegs by MDCK-hMDR1 cells is enhanced by P-gp inhibitors;(b)pegs stimulate P-gp ATPase activity but to a much lesser extent than verapamil;and(c)uptake of pegs of low MW(pegs of hish MW(>5000 Da)occurs by a combination of passive diffusion and caveolae-mediated *** findings suggest that pegs can engage in P-gp-based drug interactions which we believe should be taken into account when using pegs as excipients and in PEGylated drugs and drug delivery systems.

关键词： P-gp pegs P-gp-substrate Passive diffusion Endocytosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reproductive development of two groundnut cultivars as influenced by boron and light

引用

Information Processing in Agriculture 2018年第2期5卷 289-293页

作者： Md.Quamruzzaman Md.Jafar Ullah Md.Fazlul Karim Nazrul Islam Md.Jahedur Rahman Md.Dulal Sarkar Department of Agronomy Sher-e-Bangla Agriculture UniversityDhaka 1207Bangladesh Department of Horticulture Sher-e-Bangla Agriculture UniversityDhaka 1207Bangladesh

Boron is an important micronutrient that enhances reproductive growth of crops such as *** also plays an important role for pegging of *** has been little information on the application of boron and light in groundnut in Bangladesh.A field experiment was conducted to study the effects of boron and light on the reproductive development of two groundnut *** considered as two groundnut cultivars,viz.,‘Dhaka-1(C1)’and‘BARI Chinabadam-8(C2)’,three levels of boron(B),viz.,0-kg B ha^-1(B0),1-kg B ha^-1(B1)and 2-kg B ha^-1(B2),and two levels of light,viz.,normal day light(≈12-h light)and normal day light+6-h extended red light at night(≈18-h light).Result revealed that the reproductive development,yield and shelling percentage of groundnut were markedly increased with the application of *** to imposition of light all of reproductive units increased but decrease number of pods and pod *** highest reproductive unit and yield were observed from‘BARI Chinabadam-8’.Therefore,reproductive development could be improved by application of boron in improved cultivars(BARI Chinabadam-8)but not for under extended light.

关键词： Groundnut Reproductive development Light Boron pegs Pods Shelling percentage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

氨基酸对无外源激素悬浮培养肉苁蓉细胞合成苯乙醇苷的影响

引用

生物加工过程 2010年第6期8卷 22-27页

作者：沈慧慧易丽娟李春新疆兵团化工绿色过程重点实验室石河子832003 阿克苏出入境检验检疫局阿克苏843000

通过不添加外源激素进行肉苁蓉细胞悬浮培养,考察4种氨基酸对无外源激素悬浮培养肉苁蓉细胞生长和产苯乙醇苷(pegs)的影响。结果表明:苯丙氨酸(Phe)和酪氨酸(Tyr)对pegs合成的促进作用较大,而色氨酸(Try)和精氨酸(Arg)的促进效果较弱。... 详细信息

通过不添加外源激素进行肉苁蓉细胞悬浮培养,考察4种氨基酸对无外源激素悬浮培养肉苁蓉细胞生长和产苯乙醇苷(pegs)的影响。结果表明:苯丙氨酸(Phe)和酪氨酸(Tyr)对pegs合成的促进作用较大,而色氨酸(Try)和精氨酸(Arg)的促进效果较弱。在培养的第12天向无外源激素液体培养基中分别添加0.3mmol/LPhe和0.03mmol/LTyr,pegs产量(按细胞干质量计)均达到了最高,为1.19g/L,是添加生长调节剂激动素(KT)和吲哚乙酸(IAA)培养的细胞(简称HC)的2.02倍。0.3mmol/LPhe和0.03mmol/LTyr分别在第8天和第12天添加时,肉苁蓉细胞pegs产量分别为5.43g/L和5.16g/L,分别是对照HC的1.49倍和1.41倍。

关键词：氨基酸肉苁蓉培养激素 pegs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：