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Polyethylene glycol(peg-400):An efficient and recyclable reaction medium for the synthesis of novel 1,5-benzodiazepines and their antimicrobial activity

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Chinese Chemical Letters 2011年第1期22卷 65-68页

作者： Shankaraiah G.Konda Baseer M.Shaikh Sanjay A.Chavan Bhaskar S.Dawane Organic Research Laboratory Department of Chemistry Yeshwant MahavidyalayaNanded-431602(M.S) India

一个新系列包含咪唑 1， 5-benzodiazepines 被 chalcones 的冷凝作用与在聚乙烯乙二醇(peg-400 ) 把哌啶用作有效、绿的反应溶剂的 o-phenylenediamine 综合了。这个协议的优点是环境友好，容易的病情的检查，高收益，温和反应条件和... 详细信息

一个新系列包含咪唑 1， 5-benzodiazepines 被 chalcones 的冷凝作用与在聚乙烯乙二醇(peg-400 ) 把哌啶用作有效、绿的反应溶剂的 o-phenylenediamine 综合了。这个协议的优点是环境友好，容易的病情的检查，高收益，温和反应条件和昂贵的催化剂的回避。而且，最新综合了混合物为他们的抗菌剂活动被评估。

关键词：聚乙二醇抗菌活性苯二胺 peg 反应介质循环再造合成反应溶剂

Improvement of True Green Porosity, Sinterability and Microstructure in Alumina Ceramics by Filter Pressing

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Journal of Materials Science & Technology 2005年第1期21卷 105-108页

作者： RenjieZENG B.Rand Dept.ofMaterialsScience&Engineering XiamenUniversityXiamen361005China Dept.ofProcess Environment&MaterialsEngineeringLeedsUniversityLeedsLS29JTUK

Comparison between filter pressing and isostatic pressing for submicrometer alumina powder has been systematically made. Obvious improvements in true porosity, sintering behaviour, and microstructure of green compacts... 详细信息

关键词： Porosimetry Agglomerate Sintering dilatometry pH peg

Amberlyst-15 in peg：A novel catalytic system for the facile and efficient one-pot synthesis of benzothiazolo-[2,3-b]-quinazolinone derivatives

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Science China Chemistry 2012年第10期55卷 2154-2160页

作者： MAZAAHIR Kidwai RITIKA Chauhan DIVYA Bhatnagar Green Chemistry Research Laboratory Department of ChemistryUniversity of Delhi

A simple and convenient approach for the synthesis of tetraheterocyclic benzothiazolo-[2,3-b]-quinazolin-1-ones has been developed utilizing the MCR methodology, which involves the condensation of 2-aminobenzothiazole, cyclic-diketones and various aldehydes using Amberlyst-15 in peg 400 as an environmentally benign and reusable catalyst system. Environmental benignity, recyclability, cost-effectiveness, easy workup and excellent yields are the major attributes of this one-pot procedure.

关键词：一锅法合成大孔树脂酮衍生物 peg 喹唑啉催化体系轻便氨基苯并噻唑

peg3000修饰的脂质体流感疫苗冻干粉稳定性及安全性

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中国生物制品学杂志 2022年第6期35卷 659-663页

作者：刘晓琳李漂张茜杨艾鲁卫东昆明医科大学药学院暨云南省天然药物药理重点实验室云南昆明650500

目的考察冻融冻干法制备的peg3000修饰的脂质体流感疫苗冻干粉稳定性及安全性。方法将冻融冻干法制备的peg3000修饰的脂质体流感疫苗混悬液和冻干粉分别储存于不同温度[4、(25±2)、(37±2)℃]下,第0、1、2、6月取样,Lowry法检测包封率... 详细信息

目的考察冻融冻干法制备的peg3000修饰的脂质体流感疫苗冻干粉稳定性及安全性。方法将冻融冻干法制备的peg3000修饰的脂质体流感疫苗混悬液和冻干粉分别储存于不同温度[4、(25±2)、(37±2)℃]下,第0、1、2、6月取样,Lowry法检测包封率,考察物理稳定性;将冻干粉分别置4、(25±2)℃条件下,原液始终储存于4℃,第1、2、3月取样,腹腔免疫小鼠7 d后,采血分离血清,微量血凝抑制法检测免疫后与免疫前抗体滴度比,考察生物稳定性。将小鼠随机分为peg3000修饰的脂质体流感疫苗冻干粉组(peg组)、原液组、脂质体组(佐剂组)、PBS组(阴性对照组),经小鼠腹腔给药(15μg血凝素),进行急性毒性试验;分别于0、14和28 d经小鼠腹腔给药(6μg血凝素),进行长期毒性试验。结果peg3000修饰的脂质体流感疫苗冻干粉(37±2)℃保存6个月,包封率达80%以上;(25±2)℃保存3个月,小鼠免疫后与免疫前抗体滴度比≥4。急性毒性试验期间,小鼠未见任何明显急性毒性反应。长期毒性试验期间,各实验组小鼠一般状况良好;体重和摄食量与阴性对照组比较未见明显变化;血液学指标均在正常范围内波动,未发现与给药相关的毒性反应;各组织脏器系统解剖观察及脏器重量均未见明显与给药相关的毒性病理学改变。结论peg3000修饰的脂质体流感疫苗冻干粉具有良好的稳定性;经小鼠急性和长期毒性试验未见明显毒性反应,具有良好的安全性。

关键词： peg 脂质体流感疫苗稳定性安全性

Optimization of protoplast isolation,transformation and its application in sugarcane (Saccharum spontaneum L.)

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The Crop Journal 2021年第1期9卷 133-142页

作者： Qiongli Wang Guangrun Yu Zhiyong Chen Jinlei Han Yufang Hu Kai Wang Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of Education/Fujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyCenter for Genomics and BiotechnologyFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina National Engineering Research Center of Sugarcane Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Sugarcane is a prominent source of sugar and ethanol production.Genetic analysis for trait improvement of sugarcane is greatly hindered by its complex genome,long breeding cycle,and recalcitrance to genetic transformation.The protoplast-based transient transformation system is a versatile and convenient tool for in vivo functional gene analysis;however,quick and effective transformation systems are still lacking for sugarcane.Here,we developed an efficient protoplast-based transformation system by optimizing conditions of protoplasts isolation and peg-mediated transformation in S.spontaneum.The yield of viable protoplasts was approximately 1.26×107 per gram of leaf material,and the transformation efficiency of 80.19%could be achieved under the optimized condition.Furthermore,using this approach,the nuclear localization of an ABI5-like bZIPs transcription factor was validated,and the promoter activity of several putative DNase I hypersensitive sites(DHSs)was assessed.The results indicated this system can be conveniently applied to protein subcellular localization and promoter activity assays.A highly efficient S.spontaneum mesophyll cell protoplast isolation and transient transformation method was developed,and it shall be suitable for in vivo functional gene analysis in sugarcane.

关键词： Saccharum spontaneum L. Protoplast isolation peg Transformation efficiency Transient expression

pegylation in anti-cancer therapy: An overview

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 337-348页

作者： Prajna Mishra Bismita Nayak R.K.Dey Centre for Applied Chemistry Central University of Jharkhand Department of Life Science National Institute of Technology

Advanced drug delivery systems using poly(ethylene glycol)(peg) is an important development in anti-cancer therapy. pegylation has the ability to enhance the retention time of the therapeutics like proteins, enzymes small molecular drugs, liposomes and nanoparticles by protecting them against various degrading mechanisms active inside a tissue or cell, which consequently improves their therapeutic potential. pegylation effectively alters the pharmacokinetics(PK) of a variety of drugs and dramatically improves the pharmaceutical values;recent development of which includes fabrication of stimuli-sensitive polymers/smart polymers and polymeric micelles to cope of with the pathophysiological environment of targeted site with less toxic effects and more effectiveness. This overview discusses pegylation involving proteins, enzymes, low molecular weight drugs, liposomes and nanoparticles that has been developed, clinically tried for anti-cancer therapy during the last decade.

关键词： peg pegylation Targeted drug delivery Polymers

Effect of Hydrolyzing Agents on the Properties of Poly(Ethylene Glycol)-Fe_3O_4 Nanocomposite

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Nano-Micro Letters 2011年第2期3卷 79-85页

作者： E.Karaoglu H.Kavas A.Baykal M.S.Toprak H.Szeri Department of Chemistry~b Fatih University Department of Physics Gebze Institute of Technology Functional Materials Division Royal Institute of Technology-KTH TUBITAK-UME National Metrology Institute

Poly(ethylene glycol)(peg) assisted hydrothermal route has been used to study the influence of the hydrolyzing agent on the properties of peg-iron oxide(Fe_3O_4) nanocomposites.Iron oxide nanoparticles(NPs),as confirmed by X-ray diffraction analysis,have been synthesized by a hydrothermal method in which Na OH and NH_3 were used as hydrolyzing agents.Formation of peg-Fe_3O_4 nanocomposite was confirmed by Fourier transform infrared spectroscopy(FTIR).Samples exhibit different crystallite sizes,which estimated based on line profile fitting as 10 nm for NH_3 and 8 nm for Na OH hydrolyzed samples.The average particle sizes obtained from transmission electron microscopy was respectively 174±3 nm for Na OH and 165±4 nm for NH3 gas hydrolyzed samples.Magnetic characterization results reveal superparamagnetic characteristics despite a large particle size,which indicate the absence of coupling between the nanocrystals due to the presence of polymer in the nanocomposites.The conductivity curve demonstrates that σDC is strongly temperature dependent.

关键词： Magnetite peg Hydrothermal synthesis Conductivity Magnetization

STUDIES ON ULTRASONIC ABSORPTION AND VISCO-RELAXATION OF POLY (ETHYLENE GLYCOL) AQUEOUS SOLUTIONS

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Chinese Journal of Polymer Science 1989年第3期7卷 270-279页

作者： SUBHI KEMAL HASSUN ALIA ABDULMUHSIN SHIHAB FATIMA ABDULAMIR JASSIM Physics Department-College of Education-University of Baghdad Iraq.Physics Department-College of Education-University of BaghdadIraq.Physics Department-College of Education-University of BaghdadIraq.

Ultrasonic absorption and velocity measurements were made on aqueous solutions of poly (ethylene glycol)(peg)of different molecular weights and concentrations, using a pulse sender-receiver ultrasonic generator, Measurements were obtained at a frequency of 2MHz. , and a temperature of 293 K. The results show a linear increase of the Values of velocity, density and viscosity with increase of molecu lar weight and concentration of peg. On the contrary, the attenuation values decreased with increase of molecular weight and concentration of peg. A mathematical equation correlating relaxation amplitude and molecular weight of the polymer is suggested. This was applied to calculate the molecular weights of unknown samples of peg from their measured relaxation amplitude. The results obtained were in good agreement with those obtained from osmometry.

关键词： peg ETHYLENE GLYCOL STUDIES ON ULTRASONIC ABSORPTION AND VISCO-RELAXATION OF POLY

Click chemistry approach to functionalize two-dimensional macromolecules of graphene oxide nanosheets

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Nano-Micro Letters 2010年第3期2卷 177-183页

作者： Liang Kou Hongkun He Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University

A facile "click chemistry" approach to functionalize 2D macromolecules of graphene oxide nanosheets with poly(ethylene glycol) of different molecular weights,polystyrene,palmitic acid and various amino acids was presented.FTIR,TGA,Raman spectroscopy,XPS,XRD,TEM,AFM and SEM were utilized to characterize the products.High degree of functionalization was achieved on the flat surfaces of graphene oxide,affording polymer-grafted 2D brushes and amino acids-immobilized nanosheets,which show improved solubility in organic solvents.The click chemistry strategy reported herein provides a facile and general method for functionalization of graphene oxide with macromolecules and desired biomolecules.

关键词： Graphene Click chemistry Chemical modification peg Amino acids