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Primary malignant melanoma of the esophagus successfully treated with camrelizumab:A case report and literature review

引用

Oncology and Translational Medicine 2022年第4期8卷 201-208页

作者： Gaoyang Lin Xin Zheng Fuman Wang Daijun Xing Yufeng Cao Department of Cardiothoracic Surgery The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China Department 3 of the Cancer Center The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China

An 83-year-old Chinese woman presented with a 3-month history of *** also had a history of hypertension,type 2 diabetes,fundus hemorrhage,and cataract but no history of cutaneous,ocular,or other-site *** gastrointestinal tract angiography revealed gastritis and duodenal diverticulum;thus,an endoscopic review was *** computed tomography of the chest and upper abdomen revealed the following:(1)Esophageal space-occupying lesions and mediastinal lymph node enlargement(considering the high possibility of esophageal cancer,further endoscopy was recommended)and(2)A small amount of right pleural effusion,with no significant lymph node infiltration or distant *** identified a bulge mass blocking the esophagus from 23 to 30 cm from the *** upper mass had a spherical clustering,while the lower mass significantly *** biopsy samples were obtained from the esophagus 23 and 28 cm from the *** biopsy showed proliferation of large round tumor cells and *** showed positive findings for HMB45 and MelanA;partially positive findings for S100,CK7,CK5/6,CAM5.2,LCA,P63,and TTF-1;and negative findings for *** Ki-67 positivity index was approximately 60%.Based on these findings,the patient was diagnosed with malignant esophageal melanoma with enlarged mediastinal lymph *** was then treated with five cycles of camrelizumab therapy combined with chemotherapy from October 18,2019,to May 5,*** review following two courses of combination therapy revealed that the esophagus was 23-25 cm away from the incisors,and there were two continuous uplifted and beaded masses that had a smooth and black surface,with each of them having a length and diameter of approximately 1 *** of the mucosa around the lumen was observed at 40 cm from the incisors to the cardia;the dentate margin was clear;and the cardia had no *** patient then received fiv

关键词： primary malignant melanoma of the esophagus pd-1 mab camrelizumab immunotherapy

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