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金雀异黄素对pcos高雄血症大鼠子宫和卵巢形态学的影响

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中国食品学报 2013年第5期13卷 11-16页

作者：迟晓星陈容张涛钱丽丽张玉梅黑龙江八一农垦大学黑龙江大庆163319 哈尔滨医科大学大庆校区黑龙江大庆163319 北京大学医学部北京100191

目的:通过建立多囊卵巢综合征(pcos)高雄血症动物模型,观察金雀异黄素(GEN)对大鼠子宫和卵巢形态学的影响。方法:按照胰岛素(INS)联合HCG造模法建立实验动物模型,分为阴性对照组、模型组、GEN低、中、高剂量组及雌激素阳性对照组,剂量... 详细信息

目的:通过建立多囊卵巢综合征(pcos)高雄血症动物模型,观察金雀异黄素(GEN)对大鼠子宫和卵巢形态学的影响。方法:按照胰岛素(INS)联合HCG造模法建立实验动物模型,分为阴性对照组、模型组、GEN低、中、高剂量组及雌激素阳性对照组,剂量组分别灌胃给予GEN5、10、20mg/kgbw,雌激素组给予己烯雌酚0.5mg/kg,持续15d,观察动情周期10d。试验结束后,取大鼠各脏器称重,计算脏体比值、卵巢和子宫的面积与体积。显微镜下分析子宫和卵巢组织形态学的变化。结果:与模型组相比,中、高剂量组大鼠的子宫/体比升高,差异有显著性(ppcos高雄血症大鼠的子宫和卵巢形态学起到了改善作用,推测GEN的植物雌激素样作用可能会对pcos患者发挥治疗作用。

关键词：金雀异黄素 pcos 高雄血症卵巢形态学

pcos and hyperandrogenism in type 1 diabetes

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Open Journal of Obstetrics and Gynecology 2012年第1期2卷 76-80页

作者： Susan Tibuni-Sanders Shahla Nader Department of Internal Medicine Endocrine Division University of Texas at Houston Houston USA

Women with both type 1 diabetes and polycystic ovarian syndrome (pcos) represent a unique population, with long term implications on fertility and diabetic complications, which need to be addressed. The studies reviewed herein address the increased incidence of pcos in women with type 1 diabetes. The leading theories suggest that the underlying pathophysiology is related to intensive insulin therapy and resulting ovarian hyperandrogenism. We have searched the literature to determine what studies have been done to address the role of insulin resistance and insulin sensitizers for reduction of hyperandrogenism in these patients. According to the available evidence, we conclude that metformin may have a role in reducing the androgenic picture in type 1 patients with pcos and insulin resistance.

关键词： Type 1 Diabetes Mellitus Hyperandrogenism pcos Metformin

Explore the Relationship between Insulin Resistance and PGC1αin pcos Mice

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Open Journal of Endocrine and Metabolic Diseases 2018年第3期8卷 71-80页

作者： Lei Chen Xin Tao Shuqi Ge Lisi Cai Xuanying Deng Center for Reproductive Medicine The Third Affiliated Hospital Sun Yet-sen University Guangzhou China Department of Infertility and Sexual Medicine The Third Affiliated Hospital Sun Yet-sen University Guangzhou China

Objective: To investigate the relationship between AMPKα, PGCα, insulin resistance and reproductive function in pcos mice and to find out the molecular mechanisms and potential therapeutic molecular targets of pathogenesis of pcos. Methods: The pcos mouse model was established by DHEA administering with Balb/c mice. And after AMPK agonist AICAR and inhibitor Compound C intervention, Fasting blood glucose, fasting insulin and testosterone levels were observed. The HOMA index was calculated. The changes of PGCα expression in ovarian tissue were observed by western blot and immunohistochemistry to determine the relationship between insulin resistance and PGCα in pcos mice. Results: Western blot and immunohistochemistry showed that PGC1α protein was expressed in the ovary of mice and the expression of PGC1α was negatively correlated with AMPKα in our study. Compared with the control group, the expression of PGC1α in the ovaries of the mice in pcos group was significantly increased (P pcos + AICAR group was lower than that in pcos group (P α in pcos mice exposed to AMPK inhibitor Compound C also decreased compared with pcos group (P Conclusion: In ovarian tissue, the insulin resistance-related AMPKα pathway in pcos mice may be negatively correlated with PGCα.

关键词： pcos Mice Insulin Resistance PGC1α

Polycystic Ovarian Syndrome (pcos): Exploring Its Impact on Obstetrical Outcomes

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1111-1123页

作者： Ranjitha Vasa Gayatri Venkataraman Kelly Gorman Rythika Francis Elise Zwicklbauer Julia Fisher Polina Safovich Mudar Dalloul Ozgul Muneyyirci-Delale Department of Obstetrics and Gynecology SUNY Downstate Health Science University Brooklyn United States of America Department of Obstetrics and Gynecology Kings County Hospital Center NYC Health and Hospitals Brooklyn United States of America

Polycystic ovarian syndrome (pcos) disrupts ovulation leading to both infertility and miscarriage;yet, its impact on obstetrical outcomes remains largely uncertain due to conflicting findings. We analyzed data from the CDC Pregnancy Risk Assessment of Monitoring System, specifically Standard Core and Phase 8 responses, with 9549 respondents across the United States through SPSS 28 software in this cross-sectional study. Two variables assessed pcos status in respondents: history of pcos and pcos during pregnancy. With a history of pcos, there were significantly increased odds of diabetic (OR 1.665, p pcos diagnosed during pregnancy, there were significantly greater odds of diabetes (OR 3.278, p pcos is a significant risk factor that contributes to maternal morbidity. Our results support the hypothesis that pcos’ impact extends well into a woman’s obstetrical journey, with varying degrees of associated adverse maternal and fetal risks. Preliminary pathophysiologic explanations associated with pcos gestational diabetes include pre-existing insulin resistance. Meanwhile, altered placentation and endovascular changes associated with pcos secondary to a baseline deranged metabolic environment predispose patients to developing hypertensive disorders, PPROM, and preterm delivery. Associations between neonatal mortality and C/S can be attributed to elevated maternal body mass index. The pathophysiologic link between pcos and the above obstetrical outcomes still remains unknown, necessitating further investigation;however, this study identifies the outcomes that

关键词： pcos Polycystic Ovarian Syndrome Obstetrics Reproduction Pregnancy

Defective Expression of the Gap Junction Protein Pannexin-1 Channel Contributes to the Formation of pcos-Realted Androgenetic Alopecia

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Advances in Reproductive Sciences 2023年第4期11卷 86-92页

作者： Sule Gencoglu Fatma Tanilir Cagiran Zercan Kali Dermatology Private G&oumlzde Akademi Hospital Malatya Turkiye Private Clinic Obstetrics and Gynecology Diyarbakir Turkey Gozde Academy Hospital Obstetrics and Gynecology Malatya Turkey

Objective: To determine serum pannexin-1 channel levels and their association with hair loss in women with pcos diagnosed with female androgenetic alopecia (FAGA). Materials and Methods: Thirty-five women with pcos who presented with diffuse and treatment-resistant progressive hair loss and were diagnosed with FAGA were included in the study. 25 patients who were diagnosed with female androgenetic alopecia but did not have pcos were considered as the control group. pcos and control groups were matched by age. Follicular miniaturization, displacement of terminal hairs with vellus hairs, and a diffuse decrease in hair density were accepted as FAGA in the trcihoscopy examination of the vertex and bitempoaral area. On the third day of the menstrual cycle serum FSH, LH, testosterone, PRL and insulin levels were measured. Insulin resistance was calculated with HOMA-IR. Serum pannexin-1 channel levels of each group were mesured with ELISA. Results: Serum pannexin 1 channels levels of FAGA group due to pcos were found to be significantly higher than FAGA patients in the control group (2.72 ± 1.09 ng/mL vs 1.65 ± 0.97 ng/mL, p pcos group were significantly higher than controls. HOMA-IR values were significantly higher and >2.5 in the pcos group compared to the controls. PRL values were similar except for one patient with elevated PRL. Serum FSH values were the same in both groups. A positive and significant correlation was found between pannexin 1 channels levels and HOMA-IR and serum testosterone levels (r = 0.650, p Conclusions: In addition to hyperandrogenemia, increased pannexin 1 channel levels may play a role in the etiology of pcos associated FAGA, as it impairs the communication between the skin and hair follicle.

关键词： Androgenetic Alopecia pcos Androgen Pannexin-1 Channel Inflammation

Sexual Function in Patients with pcos and/or Obesity before and after Metformin Treatment

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Advances in Sexual Medicine 2012年第2期2卷 25-29页

作者： Antoaneta Gateva Zdravko Kamenov University Hospital Alexandrovska Medical University of Sofia Sofia Bulgaria

The clinical signs of hyperandrogenemia, commonly seen in polycystic ovarian syndrome (pcos) patients combined with obesity and infertility can cause emotional distress. There are however few data about the psychosocial and sexual function of patients with pcos. Objectives: The aim of the study was to investigate the sexual function in patients with obesity and/or pcos using Female sexual function inventory (FSFI) before and after metformin treatment. Design and Methods: In the present study were included 79 patients divided into three groups—group 1 Obese (n = 22);group 2 Lean pcos (n = 41) and group 3 Obese pcos (n = 16). All of the subjects completed FSFI questionnaire. In patients who had insulin resistance (OGTT + IRI) metformin treatment was started in dose 1700 - 3000 mg/day. Results: Obese women without pcos showed significantly higher scores on total FSFI and all domains except from desire compared to lean pcos subjects. Although the differences do not reach statistical significance, lean pcos patients have the lowest scores on all domains. FSFI score correlates negatively only with androstendione levels. Women with and without hyperandrogenemia do not show differences in FSFI score. It is interesting to note that LH but not FSH shows moderate positive correlation to all domains of FSFI. FSFI scores do not show correlation to the indices of carbohydrate metabolism (blood glucose and IRI during OGTT), lipid profile, and arterial pressure. After metformin treatment there was an increase in all FSFI domain scores although statistical significance was noted only for the total FSFI score and the domains lubrication and pain, probably because of the small number of patients. Conclusions: Lean pcos patients have lower scores on FSFI than obese patients with or without pcos. The hyperandrogenemia is not a determinant for sexual dysfunction in pcos women. Metformin treatment has a favorable effect on sexual function.

关键词： pcos Sexual Function Metformin

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针刺治疗pcos：当前的实验和临床报道

中国中西医结合杂志 2012年第10期32卷 1436-1439页

作者：郑艳华苏念军丁涛马红霞广州医学院第一附属医院中医科广州510182 广州医学院第三附属医院妇产科广州510150

多囊卵巢综合征（polycystic ovarian syndrome,pcos）是一种生殖功能障碍与糖代谢异常并存的内分泌紊乱综合征,临床以持续无排卵、雄激素过多和胰岛素抵抗（insulin resistance,IR）为主要特征,同时还存在着远期并发症的危险,如动脉粥... 详细信息

多囊卵巢综合征（polycystic ovarian syndrome,pcos）是一种生殖功能障碍与糖代谢异常并存的内分泌紊乱综合征,临床以持续无排卵、雄激素过多和胰岛素抵抗（insulin resistance,IR）为主要特征,同时还存在着远期并发症的危险,如动脉粥样硬化、高血压、高血脂、糖尿病、子宫内膜癌等。

关键词：临床报道 pcos 针刺治疗多囊卵巢综合征实验生殖功能障碍动脉粥样硬化下丘脑-垂体

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pcos高雄激素血症的特征及鉴别诊断

实用妇产科杂志 2005年第9期21卷 524-526页

作者：乔杰李蓉北京大学第三医院北京100083

经过几十年的研究，尽管对多囊卵巢综合征（polycystic ovarian syndrome，pcos）病因及发病机制目前尚不清楚，但雄激素过多作为pcos的基本特征得到广泛认可，有报道约50％以上的中国pcos患者有高雄激素血症。因此，有必要对pcos患者... 详细信息

经过几十年的研究，尽管对多囊卵巢综合征（polycystic ovarian syndrome，pcos）病因及发病机制目前尚不清楚，但雄激素过多作为pcos的基本特征得到广泛认可，有报道约50％以上的中国pcos患者有高雄激素血症。因此，有必要对pcos患者高雄激素血症的特征进行深入探讨。[第一段]

关键词：高雄激素血症 pcos 鉴别诊断 syndrome 多囊卵巢综合征雄激素过多发病机制患者

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pcos患者的远期健康风险

山东医药 2008年第11期48卷 116-117页

作者：曲中玉安茂伟任春娥山东大学附属省立医院山东济南250021 日照市计划生育科研所潍坊医学院附属医院

pcos患者常因生殖系统功能紊乱(月经失调、不孕、高雄激素血症)及代谢功能紊乱而就诊,临床亦主要针对这些问题展开诊治。目前pcos患者的健康风险越来越引起关注,但对其代谢筛查和远期健康情况的随访等工作做得有限,既往的研究大都缺乏... 详细信息

pcos患者常因生殖系统功能紊乱(月经失调、不孕、高雄激素血症)及代谢功能紊乱而就诊,临床亦主要针对这些问题展开诊治。目前pcos患者的健康风险越来越引起关注,但对其代谢筛查和远期健康情况的随访等工作做得有限,既往的研究大都缺乏有效的对照(在家族史、压力、肥胖等方面)。如IR在pcos患者女性亲属中发生率高;pcos患者女性肿瘤的发病风险增加;而评估患者情况时,临床通常采用具有代表性的标志物,常不能评估其远期发病率。目前关于远期并发症发病率和发病风险的研究主要是基于病例研究,非随机的对照组多采用历史对照和同时间段收集的对照,有关pcos的纵向研究仍需进一步深入,以便于完善其健康评估。[第一段]

关键词： pcos 健康风险代谢功能紊乱远期发病率高雄激素血症健康评估发病风险女性肿瘤