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钙泊三醇/二丙酸倍他米松软膏获得pasi 50和pasi 75的回顾性分析

世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 19-20页

作者： Anstey A.V. Kragballe K. 朱国兴 Royal Gwent Hospital Newport United Kingdom Dr.

Background: The US National Psoriasis Foundation recently recommended that pasi 50 and pasi 75 response rates be used in clinical trials to enable comparisons across studies of different psoriasis therapies. To date, these response rates have not been reported for the two-compound ointment containing calcipotriol and betamethasone dipropionate (Daivobet/Dovobet; LEO Pharma, Ballerup, Denmark). Further, in order to compare Daivobetwith other therapeutics recently presented to the European regulatory authorities and the FDA, comparison with the biologicals, efalizumab, etanercept and alefacept, were also made. Objectives: To present the pasi 50 and pasi 75 results for the two-compound ointment containing calcipotriol and betamethasone dipropionate. Methods: Data from six phase III studies conducted with the two-compound ointment were pooled and the pasi 50 and pasi 75 response rates calculated for patients with severe (pasi≥17) or less severe disease (pasi pasi 50 and pasi 75 were achieved by more patients treated with the two-compound ointment than with the individual components. In patients with severe disease, the pasi 50 response rate after 4 weeks’treatment was 88.8%with the two-compound ointment, 69.2%with betamethasone dipropionate, 53.8%with calcipotriol, and 30.0%with ointment vehicle. In comparison, 12 weeks’treatment with the biologicals resulted in pasi 50 response rates of 59%with efalizumab, 74%with etanercept, and 56%with alefacept. Conclusions: The two-compound ointment is effective, producing a pasi 50 and pasi 75 response in greater than 80%and 50%of patients, respectively, regardless of psoriasis severity.

关键词： pasi 75 钙泊三醇卡泊三醇二丙酸倍他米松软膏膏剂

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