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World Journal of Hypertension 2015年第2期5卷 85-92页

作者： Klara Magyar Roland Gal Adam Riba Tamas Habon Robert Halmosi Kalman Toth 1st Department of Medicine University of PecsMedical School

Hypertension is an increasing health problem worldwide especially among the *** therapeutical importance is indicated by the caused organ damages like hypertensive heart disease(HHD) and heart failure with the subsequent higher morbidity and mortality in the *** HHD ventricular hypertrophy develops as a compensatory mechanism for pressure overload but as the left ventricular compliance decreases,the process can transform into heart failure with firstly preserved and then into reduced ejection fraction(HFp EF,HFr EF).The main characteristics of underlying mechanisms involve cardiomyocyte growth,vessel changes,increased collagen production in all of which several mechanical stress induced neurohumoral agents,signal transduction pathways are *** to the new ESC and AHA guidelines five main groups of antihypertensive agents can be applied for decreasing blood pressure and for the prevention of organ ***,patients are not able to tolerate antihypertensive medication because of side effects,drug intolerance or interactions thus it is more difficult to reach the target blood pressure *** there are several efforts to complete the existing therapeutical possibilities against the development of organ damages like inhibition of Rho/ROCK pathway(e.g.,statins),regulation of ROS formation,influence on mitochondrial biogenesis and enhancing recombinant adenovirus hepatocyte growth factor *** induced oxidative stress causes DNA breaks producing the activation of nuclear poly(ADP-ribose) polymerase-1(parp) enzyme that leads to energy depletion and unfavorable modulation of different kinase *** activation promotes the development of HHD,and its transition to heart *** inhibition of parp-enzyme offers another new therapeutical approach among hypertensive *** purpose of this review is to give a comprehensive summary about the most significant mechanisms in HHD and an insight into

关键词： Hypertension Hypertensive heart disease HfpEF Organ damage parp-inhibition

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