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Validation of the page-b score to predict hepatocellular carcinoma risk in caucasian chronic hepatitis b patients on treatment

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World Journal of Gastroenterology 2022年第6期28卷 665-674页

作者： Pinar Gokcen Fatih Guzelbulut Gupse Adali Ayca Gokce Degirmenci Salturk Oguzhan Ozturk Ozgur bahadir Emine Kanatsiz Mevlut Kiyak Kamil Ozdil Hamdi Levent Doganay Department of Gastroenterology Health Sciences UniversityUmraniye Teaching and Research HospitalIstanbul 34764Turkey Department of Gastroenterology Health Sciences UniversityHaydarpasa Numune Teaching and Research HospitalIstanbul 34668Turkey

bACKGROUND Several risk scores have been developed to predict hepatocellular carcinoma(HCC)risk in chronic hepatitis b(CHb)*** majority of risk scores are based on pretreatment variables that are no longer considered risk factors for HCC development due to the suppression of hepatitis b virus replication early in the course of potent antiviral treatment in most *** page-b score,which is based on platelet levels,age and sex,has been shown to accurately predict HCC risk in CHb patients on antiviral treatment in various *** We aimed to evaluate the page-b score in predicting HCC risk in Turkish CHb patients on antiviral *** In this study,we recruited 742 CHb patients who had been treated with tenofovir disoproxil fumarate or entecavir for≥1 *** groups were determined according to the page-b scores as follows:≤9,low;10-17,moderate and≥18,*** cumulative HCC incidences in each risk group were computed using Kaplan-Meier analysis and were compared using the log-rank *** accuracy of the page-b score in predicting HCC risk was evaluated using a timedependent area under the receiver operating characteristic(AUROC)curve at all study time *** and multivariate logistic regression analyses were used to assess the risk factors for HCC *** The mean follow-up time was 54.7±1.2 *** was diagnosed in 26 patients(3.5%).The cumulative HCC incidences at 1,3,5 and 10 years were 0%,0%,0%and 0.4%in the page-b low-risk group;0%,1.2%,1.5%and 2.1%in the page-b moderate-risk group;and 5%,11.7%,12.5%,and 15%in the page-b high-risk group,respectively(log-rank Ppage-b score in the prediction of HCC development at 1,3,5 and 10 years were 0.977,0.903,0.903 and 0.865,*** the multivariable analysis,older age,male sex,lower platelet levels,presence of cirrhosis,and absence of alanine aminotransferase normalization at month 6 were associated with HCC development(all P<0.05).C

关键词： Chronic hepatitis b Hepatocellular carcinoma page-b score Surveillance

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