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oxysterols as promising small molecules for bone tissue engineering: Systematic review

World Journal of Orthopedics 2020年第7期11卷 328-344页

作者： Ethan Cottrill Julianna Lazzari Zach Pennington Jeff Ehresman Andrew Schilling Naomi Dirckx Nicholas Theodore Daniel Sciubba Timothy Witham Department of Neurosurgery The Johns Hopkins University School of MedicineBaltimoreMD 21287United States

BACKGROUND Bone tissue engineering is an area of continued interest within orthopaedic surgery,as it promises to create implantable bone substitute materials that obviate the need for autologous bone ***,oxysterols–oxygenated derivatives of cholesterol-have been proposed as a novel class of osteoinductive small molecules for bone tissue ***,we present the first systematic review of the in vivo evidence describing the potential therapeutic utility of oxysterols for bone tissue *** To systematically review the available literature examining the effect of oxysterols on in vivo bone *** We conducted a systematic review of the literature following PRISMA *** the PubMed/MEDLINE,Embase,and Web of Science databases,we queried all publications in the English-language literature investigating the effect of oxysterols on in vivo bone *** were screened for eligibility using PICOS criteria and assessed for potential bias using an expanded version of the SYRCLE Risk of Bias assessment *** full-text articles examining the effect of oxysterols on in vivo bone formation were *** data included:Animal species,surgical/defect model,description of therapeutic and control treatments,and method for assessing bone *** outcome was fusion rate for spinal fusion models and percent bone regeneration for critical-sized defect *** were tabulated and described by both surgical/defect model and oxysterol ***,data from all included studies were aggregated to posit the mechanism by which oxysterols may mediate in vivo bone *** Our search identified 267 unique articles,of which 27 underwent full-text *** studies(all preclinical)met our inclusion/exclusion *** the 13 included studies,5 employed spinal fusion models,2 employed critical-sized alveolar defect models,and 6 employed critical-sized calvarial defect *** upon SYRCLE c

关键词： oxysterol Bone tissue engineering Critical-sized defect Biomaterial Orthopaedic surgery Systematic review

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