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Effect of Maximal oxygen pulse on Patients with Chronic Obstructive Pulmonary Disease

Biomedical and Environmental Sciences 2022年第9期35卷 830-841页

作者： LI Yun Xiao WANG Jun WU Bo LIN Fang TAN Chun Ting YU Gang Gang NIE Shan ZHAO Ran Ran XU Bo Department of Respiratory Medicine Capital Medical University Affiliated Beijing Friendship HospitalBeijing 100050China

Objective This study evaluated the effect of maximal oxygen pulse(O_(2)P_(max))on patients with chronic obstructive pulmonary disease(COPD)and confirmed the predictive effect on acute exacerbations of COPD(AECOPD).Methods This retrospective study included 91 participants who underwent cardiopulmonary exercise testing(CPET),lung function testing,a dyspnea scale assessment,and a 3-year follow-up.The participants were divided into two groups according to the O_(2)P_(max)value.Exercise capacity,ventilatory conditions,gas exchange efficiency,and dyspnea symptoms were compared,and the correlations between O_(2)P_(max)and these indices were evaluated.The ability of O_(2)P_(max)to predict AECOPD was examined.Results Exercise capacity,ventilatory conditions,and gas exchange efficiency were lower,and dyspnea symptom scores were higher in the impaired O_(2)P_(max)group(Poxygen uptake(VO_(2))%,VO_(2)/kg_(max),VO_(2)/kg_(max)%,WR_(AT),WR_(max),VO_(2AT),VO_(2max),and V,and was negatively correlated with EqCO_(2AT),and EqCO_(2max)(P<0.05).Most importantly,O_(2)P_(max)could be used to predict AECOPD,and the best cut-off value was 89.5%(area under the curve,0.739;95%CI,0.609–0.869).Conclusion O_(2)P_(max)reflected exercise capacity,ventilation capacity,gas exchange capacity,and dyspnea symptoms in patients with COPD and may be an independent predictor of AECOPD.

关键词： oxygen pulse Chronic obstructive pulmonary disease Cardiopulmonary exercise test Acute exacerbation

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