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Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing

Acta Pharmaceutica Sinica B 2023年第1期13卷 410-424页

作者： Hangyi Wu Pei Yang Aiqin Li Xin Jin Zhenhai Zhang HuiXia Lv Department of Pharmaceutics China Pharmaceutical UniversityNanjing 211198China The Affiliated Suqian First People's Hospital of Nanjing Medical University Suqian 223800China Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210023China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210028China

Chronic diabetic wound remains a critical challenge suffering from the complicated negative microenvironments,such as high-glucose,excessive reactive oxygen species(ROS),hypoxia and malnutrition.Unfortunately,few strategies have been developed to ameliorate the multiple microenvironments simultaneously.In this study,Chlorella sp.(Chlorella)hydrogels were prepared against diabetic wounds.In vitro experiments demonstrated that living Chlorella could produce dissolved oxygen by photosynthesis,actively consume glucose and deplete ROS with the inherent antioxidants,during the daytime.At night,Chlorella was inactivated in situ by chlorine dioxide with human-body harmless concentration to utilize its abundant contents.It was verified in vitro that the inactivated-Chlorella could supply nutrition,relieve inflammation and terminate the oxygen-consumption of Chlorella-respiration.The advantages of living Chlorella and its contents were integrated ingeniously.The abovementioned functions were proven to accelerate cell proliferation,migration and angiogenesis in vitro.Then,streptozotocininduced diabetic mice were employed for further validation.The in vivo outcomes confirmed that Chlorella could ameliorate the undesirable microenvironments,including hypoxia,high-glucose,excessiveROS and chronic inflammation,thereby synergistically promoting tissue regeneration.Given the results above,Chlorella is considered as a tailor-made therapeutic strategy for diabetic wound healing.

关键词： Chlorella sp. Diabetic wound healing oxygen production Glucose consumption ROS depletion Nutrition supplement Anti-inflammation

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维普期刊数据库

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Light is an Important Limiting Factor for the Vertical Distribution of the Largest Extant Benthic Foraminifer Cycloclypeus carpenteri

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Journal of Earth Science 2022年第6期33卷 1460-1468页

作者： Kazuhiko Fujita Yoji Kanda Takashi Hosono Department of Physics and Earth Sciences University of the RyukyusOkinawa903-0213Japan Tropical Biosphere Research Center University of the RyukyusOkinawa903-0213Japan Japan Agency for Marine-Earth Science and Technology(JAMSTEC) Global Oceanographic Data Center(GODAC)Kanagawa236-0001Japan

Cycloclypeus carpenteri is the largest extant benthic foraminifer,dwelling in the deep euphotic zone(a water depth between 60 and 130 m)of the warm oligotrophic Indo-West Pacific.This foraminifer harbors diatom endosymbionts and the foraminifer-microalgal association acts like a holobiont.To verify that light is an important limiting factor controlling the vertical(depth)distribution of living Cycloclypeus holobionts,their physiological responses to light intensity were examined by short-term metabolic measurements and long-term *** oxygen production(OP)rates measured under different light levels using an oxygen microelectrode indicate that Cycloclypeus holobionts are daily net primary producers adapted to low light levels,with slight photoinhibition(reduced net OP rates relative to a light-saturated rate)over 100μmol photons m^(−2)s^(−1).Long-term growth increments of asexually reproduced juveniles incubated for two months at different light levels ranging from 0 to 100μmol photons m^(−2)s^(−1) show that Cycloclypeus holobionts are adapted to a low light level(∼5μmol photons m^(−2)s^(−1)),but can be acclimatized to a certain low light ranges(<50μmol photons m^(−2)s^(−1)).These experimental results confirm that light is an important environmental gradient affecting the vertical distribution of Cycloclypeus holobionts.

关键词： algal symbiosis diatom large benthic foraminifer oxygen production photosynthesis

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Visible light-driven water oxidation using metal oxide quantum dots modified with a cobalt catalyst

Visible light-driven water oxidation using metal oxide quant...

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中国化学会第九届全国无机化学学术会议

作者： Fujun Niu Ning Zhang Shaohua Shen Liejin Guo International Research Center of Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong University

Conversion of sunlight to chemical fuels is the holy grail to deal with the energy and environment issue.1,2 Inspired by the natural photosynthesis, molecular based photocatalytic system has been widely investigated. Generally speaking, such a system contains three part: a sensitizer to absorb light, a reduction catalyst to generate H2, and an oxidation catalyst to produce O2. The oxidation of water has been proved to be the key of the entire water splitting process, as the reaction kinetic limitation step.3 In this work, we developed a novel system with Co3O4 quantum dots（QDs） or Fe2O3 QDs as photosensitizer, a salophen cobalt（II） complex（Co SLP） as catalyst, and persulfate（S2-2O8） as the sacrificial electron acceptor（Fig. 1）. The photocatalytic oxygen evolution rate of the systems were 75μmol/h/g and 84μmol/h/g over the cobalt（II） complex when Co3O4 QDs or Fe2O3 QDs was employed, respectively. While no O2 evolution were observed when either salophen cobalt（II） complex or QDs was absent. This high efficiency might be attributed to the interfacial hole transfer from photoexcited QDs to the cobalt（II） complex.

关键词： artificial photosynthesis oxygen production quantum dots cobalt catalyst

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陶瓷透氧膜及相关膜过程研究

陶瓷透氧膜及相关膜过程研究

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2015年第十四届全国应用化学年会

作者：江河清中国科学院青岛生物能源与过程研究所

＜正＞陶瓷透氧膜在高温条件下同时具有氧离子和电子导电性能,当膜两侧存在氧浓度差时,氧气将从一侧转移到膜的另一侧,从而可以用于纯氧或富氧空气的制备。相对目前的深冷制氧技术,陶瓷透氧膜技术的制氧成本可以减少约三分之一,未来有... 详细信息

＜正＞陶瓷透氧膜在高温条件下同时具有氧离子和电子导电性能,当膜两侧存在氧浓度差时,氧气将从一侧转移到膜的另一侧,从而可以用于纯氧或富氧空气的制备。相对目前的深冷制氧技术,陶瓷透氧膜技术的制氧成本可以减少约三分之一,未来有望用于富氧燃烧技术的火电厂。此外,陶瓷透氧膜还可以作为膜反应器用于低碳烷烃的选择性氧化。此处,我们将重点讨论几种陶瓷透氧膜材料在CO2或化学反应气氛下的稳定性。同时利用膜反应器的耦合策略,将烷

关键词： oxygen-permeable membranes oxygen production hydrogen production nitrogen oxide decomposition

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