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Synergistic chemotherapy/PTT/oxygen enrichment by multifunctional liposomal polydopamine nanoparticles for rheumatoid arthritis treatment

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 86-102页

作者： Xiaoling Fu Yutong Song Xianquan Feng Zhihong Liu Wenhao Gao Hongtao Song Qian Zhang School of Pharmacy Fujian Medical UniversityFuzhou 350108China Fuzong Clinical Medical College of Fujian Medical University Fuzhou 350025China First school of clinical medicine Nanjing Medical UniversityNanjing 211166China

Amultifunctional liposomal polydopamine nanoparticle(MPM@Lipo)was designed in this study,to combine chemotherapy,photothermal therapy(PTT)and oxygen enrichment to clear hyperproliferating inflammatory cells and improve the hypoxic microenvironment for rheumatoid arthritis(RA)treatment.MPM@Lipo significantly scavenged intracellular reactive oxygen species and relieved joint hypoxia,thus contributing to the repolarization of M1 macrophages into M2 phenotype.Furthermore,MPM@Lipo could accumulate at inflammatory joints,inhibit the production of inflammatory factors,and protect cartilage in vivo,effectively alleviating RA progression in a rat adjuvant-induced arthritis model.Moreover,upon laser irradiation,MPM@Lipo can elevate the temperature to not only significantly obliterate excessively proliferating inflammatory cells but also accelerate the production of methotrexate and oxygen,resulting in excellent RA treatment effects.Overall,the use of synergistic chemotherapy/PTT/oxygen enrichment therapy to treat RA is a powerful potential strategy.

关键词： Polydopamine Thermosensitive liposomes Photothermal therapy oxygen generation Rheumatoid arthritis

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Tumor microenvironment-responsive MnSiO_(3)-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy

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Chinese Chemical Letters 2022年第6期33卷 2959-2964页

作者： Fan Jiang Chunzheng Yang Binbin Ding Shuang Liang Yajie Zhao Ziyong Cheng Min Liu Bengang Xing Ping’an Ma Jun Lin State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Periodontology Stomatological HospitalJilin UniversityChangchun 130021China School of Physical&Mathematical Sciences Nanyang Technological UniversitySingapore 639798Singapore

Compared with traditional photodynamic therapy(PDT),ultrasound(US)triggered sonodynamic therapy(SDT)has a wide application prospect in tumor therapy because of its deeper penetration depth.Herein,a novel MnSiO_(3)-Pt(MP)nanocomposite composed of Mn Si O_(3)nanosphere and noble metallic Pt was successfully constructed.After modification with bovine serum albumin(BSA)and chlorine e6(Ce6),the multifunctional nanoplatform Mn SiO_(3)-Pt@BSA-Ce6(MPBC)realized the magnetic resonance imaging(MRI)-guided synergetic SDT/chemodynamic therapy(CDT).In this nanoplatform,sonosensitizer Ce6 can generate singlet oxygen(^(1)O_(2))to kill cancer cells under US irradiation.Meanwhile,the loaded Pt has the ability to catalyze the decomposition of overexpressed hydrogen peroxide(H_(2)O_(2))in tumor microenvironment(TME)to produce oxygen(O_(2)),which can conquer tumor hypoxia and promote the SDT-induced^(1)O_(2)production.In addition,MP can degrade in mildly acidic and reductive TME,causing the release of Mn^(2+).The released Mn^(2+) not only can be used for MRI,but also can generate hydroxyl radical(^·OH)for CDT by Fenton-like reaction.The multifunctional nanoplatform MPBC has high biological safety and good anticancer effect,which displays the great latent capacity in biological application.

关键词： Sonodynamic therapy Chemodynamic therapy Artificial enzyme oxygen generation Synergetic therapy

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Bipyridine-based ruthenium precursor coordination carbon nitride nanosheets for cancer cell phosphorescence imaging and photodynamic therapy of hypoxic tumors

Bipyridine-based ruthenium precursor coordination carbon nit...

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第十一届全国化学生物学学术会议

作者： Fangmian Wei Shi Kuang Xinxing Liao Jiangping Liu Liang-Nian Ji Hui Chao MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-Sen University

This paper reported on a multifunctional nanosheet similar to ruthenium complex(Ru@CN) to overcome the hypoxic environment of tumors and improve photodynamic therapy.Based on the coordination of the nitrogen atom in the graphite phase carbon nitride(g-CN) nanosheet with the central ruthenium atom of Ru(bpy)Cl,a multifunctional nanosheet with simple structure and good water solubility is formed.The nanosheet was confirmed autocatalyze the decomposition of HO to generate oxygen in a hypoxic environment,effectively generated singlet oxygen under visible light irradiation,and accelerated the ability to catalytically decompose HO to produce oxygen.Ru@CN nanosheet was demonstrated to alleviate tumor hypoxiain vivo and in vitro,thereby increasing the anti-tumor effect of PDT.In addition,Ru@CN nanosheet have a longer phosphorescence lifetime(603 ns),and thus are used as phosphorescence imaging of human epidermal melanin tumor cells(A375).Our findings provide a new way to improve the hypoxic microenvironment of tumors and promote the production of O under tumors.White light excitation will bring great potential for in vivo air-conditioning control of tumors.

关键词： Tumor hypoxia White light Hydrogen peroxide decomposition oxygen generation Photodynamic therapy

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