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Study of locust bean gum reinforced cyst-chitosan and oxidized dextran based semi-IPN cryogel dressing for hemostatic application

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Bioactive Materials 2018年第3期3卷 370-384页

作者： Lalit Kumar Meena Pavani Raval Dhaval Kedaria Rajesh Vasita School of Life Sciences Central University of GujaratSector-30Gandhinagar 382030India Government Engineering College Sector-28Gandhinagar 382028India

Severe blood loss due to traumatic injuries remains one of the leading causes of death in emergency *** continues to be the candidate material for hemostatic applications due to its inherent hemostatic ***,available chitosan-based dressings have been reported to have an acidic odor at the wound site due to the incorporation of acid based solvents for their fabrication and deformation under compression owing to low mechanical strength limiting its *** the present study semi-IPN cryogel was fabricated via Schiff's base cross-linking between the polyaldehyde groups of oxidized dextran and thiolated chitosan in presence of locust bean gum(LBG)known for its *** at12C yielded macroporous semi-IPN cryogels with an average pore size of 124.57±20.31 mm and 85.46%*** hydrophobicity index of LBG reinforced semi-IPN cryogel was reduced 2.42 times whereas the swelling ratio was increased by 156.08%compare to control *** increased hydrophilicity and swelling ratio inflated the compressive modulus from 28.1 kPa to 33.85 for LBG reinforced semi-IPN *** structural stability and constant degradation medium pH were also recorded over a period of 12 *** cryogels demonstrated lower adsorption affinity towards *** cytotoxicity assays(direct,indirect)with 3T3-L1 fibroblast cells confirmed the cytocompatibility of the *** hemolysis assay showed<5%hemolysis confirming blood compatibility of the fabricated cryogel,while whole blood clotting and platelet adhesion assays confirmed the hemostatic potential of semi-IPN cryogel.

关键词： Chitosan oxidized dextran Locust bean gum Cryogel Hemostasis

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Injectable conductive gelatin methacrylate/oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment

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Bioactive Materials 2022年第7期7卷 119-134页

作者： Shuoji Zhu Changjiang Yu Nanbo Liu Mingyi Zhao Zerui Chen Jian Liu Ge Li Huanlei Huang Huiming Guo Tucheng Sun Jimei Chen Jian Zhuang Ping Zhu Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510100China

Umbilical cord mesenchymal stem cells(UCMSCs)transplantation has been proposed as a promising treatment modality for myocardial infarction(MI),but the low retention rate remains a considerable *** natural polymer hydrogels with conductivity ability are highly desirable as cell delivery vehicles to repair infarct myocardium and restore the cardiac *** this work,we developed a hydrogel system based on gelatin methacrylate(GelMA)and oxidized dextran(ODEX)as cell delivery vehicles for *** dopamine could be used as a reductant of graphene oxide(GO)to form reductive GO(rGO).By adjusting the amount of rGO,the conductivity of hydrogels with 0.5 mg/mL rGO concentration(≈10^(-4)S/cm)was similar to that of natural heart *** vitro cell experiments showed that the prepared hydrogels had excellent biocompatibility and cell delivery ability of *** importantly,GelMA-O5/rGO hydrogel could promote UCMSCs growth and proliferation,improve the myocardial differentiation ability of UCMSCs,and up-regulate the expression of cTnI and *** in vivo experiments demonstrated that GelMA-O5/rGO/UCMSCs Hydrogel could significantly improve the ejection fraction(EF)of rats and significantly reduce myocardial infarct area compared to PBS group,promote the survival of UCMSCs,enhance the expression level of cTnI and Cx43,and decrease the expression level of *** findings of this study suggested that the injectable conductive GelMA-O5/rGO hydrogel encapsulating UCMSCs could improve damaged myocardial tissue and reconstruct myocardial function,which will be a promising therapeutic strategy for cardiac repair.

关键词： GelMA oxidized dextran Conductivity Stem cell therapy Myocardial infarction

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