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Senna petersiana inhibits key digestive enzymes and modulates dysfunctional enzyme activities in oxidative pancreatic injury

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Asian Pacific Journal of Tropical Biomedicine 2022年第7期12卷 300-311页

作者： Kolawole A.Olofinsan Ochuko L.Erukainure Nontokozo Z.Msomi Md.Shahidul Islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Objective:To evaluate the effect of Senna petersiana leaf extracts on key digestive enzymes and FeSO_(4)-induced oxidative ***:Dried Senna petersiana leaf powder(60 g)was defatted in n-hexane and then extracted sequentially at room temperature with dichloromethane,methanol,and distilled *** total phytochemical content of the extracts was estimated using established *** in vitro antioxidant,anti-lipase,and antidiabetic activities and the effect of the extracts on intestinal glucose absorption and FeSO_(4)-induced pancreatic oxidative injury were determined using different ***,GC-MS analysis was performed to identify the main compounds of the plant *** docking analysis was also carried out to evaluate the binding energy of compounds with digestive ***:Senna petersiana leaf extracts showed significant antioxidant activities in FRAP,DPPH,and hydroxyl radical scavenging *** also inhibited pancreatic lipase and lowered intestinal glucose absorption by suppressing activities ofα-amylase andα-*** with the extracts also lowered lipid peroxidation(malondialdehyde),nitric oxide level,acetylcholinesterase,and ATPase activities with simultaneous improvement of antioxidant(catalase,superoxide dismutase,glutathione)capacity in the type 2 diabetes model of oxidative pancreatic ***-MS characterization of the extracts revealed the presence of stilbenoids,alkaloids,and other *** docking screening assay indicated the extract phytochemicals showed strong interaction with the active site amino acids of the targeted digestive *** the Senna petersiana compounds,veratramine had the highest affinity forα-amylase and lipase,whereas dihydrostilbestrol was most attracted toα-***:Senna petersiana inhibits carbohydrate digestive enzymes,reduces intestinal glucose absorption,and exerts ameliorative effects on FeSO_(4)-induced oxidative pancreatic injury wi

关键词： Senna petersiana Antioxidant Digestive enzymes oxidative pancreatic injury Type 2 diabetes

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