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Cascading failures of overload behaviors using a new coupled network model between edges

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Chinese Physics B 2022年第1期31卷 704-710页

作者： Yu-Wei Yan Yuan Jiang Rong-Bin Yu Song-Qing Yang Cheng Hong School of Information Engineering Nanchang Hangkong UniversityNanchang 330063China

With the development of network science,the coupling between networks has become the focus of complex network ***,previous studies mainly focused on the coupling between nodes,while ignored the coupling between *** propose a novel cascading failure model of two-layer *** model considers the different loads and capacities of edges,as well as the elastic and coupling relationship between *** addition,a more flexible load-capacity strategy is adopted to verify the *** simulation results show that the model is *** networks have different behaviors for the same *** changing the load parameters,capacity parameters,overload parameters,and distribution parameters reasonably,the robustness of the model can be significantly improved.

关键词： cascade failure overload load distribution edge-based

Influence of high overload on the collimating lenses of laser ranging systems

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Defence Technology（防务技术） 2020年第2期16卷 354-361页

作者： Lin Gan He Zhang Bin Liu Junhong Wang Nanjing University of Science and Technology School of Mechanical EngineeringNanjing 210094China Northwest Industrial Group Co. Ltd.Xi’anChina

Collimating lenses are an important component of laser ranging systems,and high overload environments severely affect the beam shaping effect of such *** study proposes a buffer isolation method on the basis of impact stress wave attenuation theory for collimating lens spacers,ANSYS finite element software was applied to simulate the high load dynamics of collimating lenses,and the buffer isolation performance of different materials and composite structures was compared and *** simulation analysis of the collimating lenses under different buffer conditions was performed using ZEMAX software to study the mechanism by which a high overload affects the collimating *** overload and optical shaping experiments based on theoretical analysis were further *** showed the superiority of butadiene rubber to polytetrafluoroethylene after application of 70000 g impact *** combination-gasket method was superior to the single-gasket method,and the sandwich combination-gasket method was superior to the double-layer combination-gasket method.

关键词： High overload Laser ranging Emission lens Buffer isolation

PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function

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Bone Research 2024年第3期12卷 621-633页

作者： Yan Shao Hongbo Zhang Hong Guan Chunyu Wu Weizhong Qi Lingfeng Yang Jianbin Yin Haiyan Zhang Liangliang Liu Yuheng Lu Yitao Zhao Sheng Zhang Chun Zeng Guiqing Wang Xiaochun Bai Daozhang Cai Department of Joint Surgery Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina Department of Orthopedics Orthopedic Hospital of Guangdong ProvinceAcademy of Orthopedics Guangdong ProvinceThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina The Third School of Clinical Medicine Southern Medical UniversityGuangzhouChina Orthopedics Department Qingyuan People’s HospitalThe Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuanGuangdongChina Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdongChina

Mechanical overloading and aging are two essential factors for osteoarthritis(OA)*** have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte biology,but their roles and the associated mechanisms in mechanical stress-associated chondrocyte senescence and OA have not been elucidated.

关键词： overload aging stress

Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1239-1247页

作者： Lei Yang Hao Wang Xiang Yang Qian Wu Peng An Xi Jin Weiwei Liu Xin Huang Yuzhu Li Shiyu Yan Shuying Shen Tingbo Liang Junxia Min Fudi Wang Department of Nutrition Precision Nutrition Innovation CenterSchool of Public HealthZhengzhou University450001 ZhengzhouChina The First Affiliated Hospital School of Public HealthInstitute of Translational MedicineZhejiang University School of Medicine310058 HangzhouChina Department of Nutrition and Health Beijing Advanced Innovation Center for Food Nutrition and Human HealthChina Agricultural University100193 BeijingChina School of Nursing Xinxiang Medical University453003 XinxiangChina

Iron homeostasis is essential for health;moreover,hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading ***,we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 *** validated the results in C57BL/6J mice and a mouse model of hemochromatosis(Hfe^(−/−)mice).Our screen revealed that the anti-rheumatoid arthritis drug auranofin(AUR)potently upregulates hepcidin ***,we found that canonical signaling pathways that regulate iron,including the Bmp/Smad and IL-6/Jak2/Stat3 pathways,play indispensable roles in mediating AUR’s *** addition,AUR induces IL-6 via the NF-κB *** C57BL/6J mice,acute treatment with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling and decreased serum iron and transferrin *** chronically treating male Hfe^(−/−)mice with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling,decreasing systemic iron overload,but less effective in *** analyses revealed that estrogen reduced the ability of AUR to induce IL-6/hepcidin signaling in Huh7 cells,providing a mechanistic explanation for ineffectiveness of AUR in female Hfe^(−/−)***,high-dose AUR(25 mg/kg)induces ferroptosis and causes lipid peroxidation through inhibition of thioredoxin reductase(TXNRD)*** demonstrate the ferroptosis inhibitor ferrostatin significantly protects liver toxicity induced by highdose AUR without comprising its beneficial effect on iron *** conclusion,our findings provide compelling evidence that TXNRD is a key regulator of ferroptosis,and AUR is a novel activator of hepcidin and ferroptosis via distinct mechanisms,suggesting a promising approach for treating hemochromatosis and hepcidin-deficiency related disorders.

关键词： peroxidation overload mechanisms

Towards a degradation-based mechanism for adaptive overload control

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Science China(Information Sciences) 2012年第12期55卷 2708-2722页

作者： WANG ZiYou 1,2,ZHOU MingHui 1,2 & MEI Hong 1,2 1 Software Institute,School of Electronics Engineering and Computer Science,Peking University,Beijing 100871,China 2 Key Laboratory of High Confidence Software Technologies(Peking University),Ministry of Education,Beijing 100871,China Software Institute School of Electronics Engineering and Computer Science Peking University Beijing China Ministry of Education Key Laboratory of High Confidence Software Technologies (Peking University) Beijing China

Uncontrolled overload is one of the major causes of the system's decline in reliability and performance for web *** also harms the construction of trustworthy *** paper presents a degradationbased mechanism to adaptively control overload in complex,dynamic web *** our mechanism,the bottlenecks in the application's performance are determined by internally monitoring the performance and resource utilization state of the application,which is decomposed into a set of *** locating the bottlenecks,two decision algorithms are proposed to dynamically and adaptively generate proper degradation plans without *** degrading the service which consumes critical resources and has a low priority from the perspective of business logic,the application can keep providing key services even when overload *** implement a prototype and conduct a case study on a wiki *** also evaluate our approach and demonstrate its effectiveness in simulated overload *** handling overload,we make a breakthrough in building trustworthy software in an open,dynamic and rapidly changing environment.

关键词： overload service degradation resource monitoring performance management

EFFECT OF overload ON CRACK GROWTH IN FIBER REINFORCED METAL LAMINATES

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Chinese Journal of Aeronautics 1998年第4期11卷 58-62页

作者：郭亚军吴学仁 Natl. Key Lab. of Adv. Composites Beijing Inst. of Aero. Materials Beijing 100095 China

This paper is concerned with fatigue behavior of glass fiber reinforced aluminium laminates (GLARE) under overload fatigue loading. The effect of single overload on the crack growth rates in GLARE was investigated, and the mechanism of the retardation of crack growth determined. Crack growth retardation by overload was observed in GLARE, but much smaller than monolithic metals. The retardation of crack growth in GLARE is only controlled by the effective stress intensity factor experienced by the constituent metals at crack tips.

关键词： GLARE fatigue crack growth rate overload retardation

Targeting at SUR2B/Kir6.1 subtype of ATP-sensitive potassium channel opener natakalim improves pressure overload-induced heart failure

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沈阳药科大学学报 2008年第S1期25卷 96-97页

作者： TANG Yuan1,2,LONG Chao-liang2,WANG Hai2(1.Institute of Materia Medica,College of Pharmacy,Third Military Medical University,Chongqing 400038,China 2.Department of Cardiovascular Pharmacology,Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China)

Objective To explore the new stratigies targeting at SUR2B/Kir6.1 subtype against pressure overload-induced heart *** Pressure overload-induced heart failure was induced in Wistar rat by abdominal aortic banding(AAB).The effects of natakalim(1,3,9 mg·kg-1·d-1,10 weeks)were assessed on myocardial hypertrophy and heart failure,cardiac histology,vasoactive compounds,and gene *** working heart and isolated tail artery helical strips were used to examine the influence of natakalim on heart and resistant *** Ten weeks after the onset of pressure overload,natakalim therapy potently inhibited cardiac hypertrophy and prevented heart *** inhibited the changes of left ventricular haemodynamic parameters,reversed the increase of heart mass index,left ventricular weight index and lung weight index *** examination demonstrated that there were no significant hypertrophy and fibrosis in hearts of pressure overload rat treated with *** examination of heart revealed well-organized myofibrils with mitochondria grouped along the periphery of longitudinally oriented fibers in natakalim group *** content of serum NO and plasma PGI2 was increased,while that of plasma ET-1 and cardiac tissue hydroxyproline,ANP and BNP mRNA was down-regulated in natakalim-treated *** at concentrations ranging from 0.01-100 μM had no effects on isolated working heart derived from Wistar rats;however,natakalim had endothelium-dependent vasodilation effects on the isolated tail artery helical strips precontracted with *** These results indicate that natakalim improves heart failure due to pressure overload by activating KATP channel SUR2B/Kir6.1 subtype and reversing endothelial dysfunction.

关键词： natakalim pressure overload KATP channel SUR2B/Kir6.1

EXPERIMENTAL STUDIES ON THE EFFECT OF overload ON FATIGUE CRACK GROWTH

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Acta Mechanica Sinica 1986年第2期2卷 146-157页

作者： Yang Bingxian Beijing Institute of Aeronautics and Astronautics Beijing Institute of Aeronautics and Astronautics Beijing China

The fatigue crack growth behavior resulting from a single overload *** order to clarify the mechanism of overload on fatigue crack growth, the processes of crack closureand opening and their stress levels are monitored by strain gages placed on the back surface ofspecimens, and the fracture surface morphologies are examined by the *** results may be used to explain quantitatively the mechanisms of retardation anddelayed retardation after a single overload.

关键词： overload retardation fracture surface morphology microfractography void dimple striation quasi-cleavage effective stress intensity factor range.

High Incidence of Pulmonary Tuberculosis in ART Naive Remunerated Blood Donors with Human Immunodeficiency Virus Type-1 Infection: Possible Role of Iron overload

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Journal of Biosciences and Medicines 2018年第2期6卷 62-82页

作者： Debasish Chattopadhya Usha Baveja Centre for AIDS and Related Diseases National Centre for Disease Control 22-Sham Nath Marg Delhi India Department of Microbiology Faculty of Medical and Health Sciences SGT University Gurgaon India Department of Pathology and Lab Medicine Medanta the Medicity Gurgaon India

Iron overload is reported to be associated with immune alterations and increased susceptibility to infections. HIV infection is characterized by progressive immunodeficiency leading to invasion by opportunistic pathogens. It was of interest to find out if disease course in HIV type-1 infection could have any relation with alteration in body iron status among individuals with history of oral iron intake. A follow-up study of immunologic and virologic markers in relation to disease progression was undertaken on asymptomatic HIV-1 positive blood donors with history of oral iron intake (subgroup I) compared to those without such history (subgroup II). High serum iron was associated with elevated levels of Th2 category of cytokines, heightened immune activation, faster decline in CD4 + T lymphocyte count and higher viral set point. Pulmonary tuberculosis (PT) was the most common AIDS related illness (ARI) (>70%) recorded among subgroup I compared to non-PT category of ARI. Median ARI free duration (months) was shorter among those who developed PT compared to those developing non-PT category of ARI i.e. 30 (95% CI as 26,32) versus 67(95% CI as 60,71) in subgroup I and 47 (95% CI as 42,49) versus 80 (95% CI as 72,87) in subgroup II (P P overload resulting from excess intake of iron may be associated with qualitative defects in cell mediated immunity at early stage of HIV-1 infection that may facilitate subsequent acquisition of pulmonary tuberculosis, shorter ARI free duration and reduced survival.

关键词： Iron overload HIV-1 Cytokines CD4 + T Lymphocyte Pulmonary Tuberculosis