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World Journal of Gastroenterology 2014年第16期20卷 4811-4816页

作者： Odile Warling Christophe Bovy Carla Combra Timothée Noterdaeme Jean Delwaide Edouard Louis Department of Internal Medicine CHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Internal Medicine NephrologyCHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Abdominal Surgery and Transplantation CHU de LiègeUniversity of Liège4000 LiegeBelgium Department of Cardiovascular Surgery German Heart Center80636 MunichGermany Department of Internal Medicine GastroenterologyCHU de LiègeUniversity of Liège4000 LiegeBelgium

The association of primary sclerosing cholangitis(PSC)and autoimmune hepatitis(AIH)is known as an overlap syndrome(OS).OS can also be described in the setting of concomitant presence of AIH and *** diseases can in some cases be associated with ulcerative *** this case report we describe,to our knowledge,the first case in the literature of a young Caucasian male suffering from ulcerative colitis and an overlap syndrome consisting of an association betweenPSC-AIH,with the concomitant presence of a membranous glomerulonephritis.

关键词： Primary sclerosing cholangitis Autoimmune hepatitis overlap syndrome Ulcerative colitis Membranous glomerulonephritis

Primary pulmonary plasmacytoma accompanied by overlap syndrome:A case report and review of the literature

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World Journal of Clinical Cases 2020年第20期8卷 4999-5006页

作者： Yi Zhou Xiao-Hong Wang Shuang-Shuang Meng Hui-Chao Wang Yu-Xia Li Rui Xu Xu-Hong Lin Department of Radiology Huaihe Hospital of Henan UniversityKaifeng 475000Henan ProvinceChina Department of Invasive Technology Huaihe Hospital of Henan UniversityKaifeng 475000Henan ProvinceChina Department of Clinical Laboratory Translational Medicine CenterHuaihe Hospital of Henan UniversityKaifeng 475000Henan ProvinceChina Department of Nephrology First Affiliated Hospital of Henan UniversityKaifeng 475000Henan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)is a rare kind of soft tissue plasma cell neoplasm without bone marrow involvement;this type of plasma cell neoplasm involves a lack of other systemic characteristics of multiple *** pulmonary plasmacytoma(PPP),with no specific clinical manifestations,is an exceedingly rare type of *** of its complexity,PPP is often difficult to diagnose,and there is no report in the literature on cases accompanied by overlap syndrome(OS).CASE SUMMARY A 61-year-old woman without a familial lung cancer history was admitted to our hospital in 2018,for intermittent cough,expectoration,and a stuffy feeling in the chest for 50 years;these symptoms appeared intermittently,especially occurred after being cold,and had been aggravated for the last 10 *** was diagnosed with pulmonary fibrosis and emphysema,bronchiectasis,OS,and autoimmune hepatic cirrhosis in 2017.A pulmonary examination revealed rough breath sounds in both lungs;other physical examinations found no obvious abnormalities.A routine laboratory work-up showed decreased haemoglobin,increased ESR,and abnormal GGT,ALT,Ig G,γ-globulin,κ-light chain,λ-light chain,rheumatoid factor,and autoimmune *** computed tomography demonstrated abnormally concentrated 99 m *** computed tomography revealed a soft tissue mass in the middle and lower lobes of the right *** right middle and inferior lobe resection with complete mediastinal lymph node dissection,immunohistochemical analysis revealed an isolated pulmonary *** patient received chemotherapy for more than 1.5 years and remains in good general *** PPP is a type of EMP,and we report an exceedingly rare presentation of PPP accompanied by OS.

关键词： Pulmonary neoplasms Plasmacytoma overlap syndrome Case report

Systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome in a 77-year-old man: A case report

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World Journal of Clinical Cases 2021年第3期9卷 707-713页

作者： Zi-Gan Xu Wei-Long Li Xi Wang Shu-Yuan Zhang Ying-Wei Zhang Xing Wei Chun-Di Li Ping Zeng Shao-Dong Luan Department of Nephrology Shenzhen Longhua District Central HospitalShenzhen 518110Guangdong ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)and antineutrophil cytoplasmic antibodyassociated vasculitis(AAV)are classically thought to cause renal impairment and small vessel vasculitis with different *** overlap constitutes a rare rheumatologic *** date,only dozens of such cases with biopsyproven glomerulonephritis have been reported worldwide typically in women of childbearing ***,we present a unique clinical case due to its rarity and individualized treatment of a Chinese man in his eighth decade of *** SUMMARY A 77-year-old man was admitted to several hospitals for shortness of breath and received nonspecific treatments over the past 3 *** his symptoms were not completely relieved,he visited our hospital for further *** examinations revealed kidney dysfunction,severe anaemia,hypocomplementemia,glomerular proteinuria,and microscopic *** antibodies,as well as anti-dsDNA antibodies,were *** tomography of the chest showed right pleural *** biopsy was performed,and histology suggested crescentic glomerulonephritis,pauci-immune *** treatment with plasmapheresis,glucocorticoid,and cyclophosphamide,the disease was in remission,and the patient remained in a stable condition for over 3 years post-hospital *** Due to its complexity and rarity,SLE and AAV overlap syndrome is easily *** accurate diagnosis and treatment at the earliest stage may significantly improve the condition and reduce irreversible organ injury.

关键词： Systemic lupus erythematosus Antineutrophil cytoplasmic antibodyassociated vasculitis overlap syndrome Elderly male Renal insufficiency Case report

Autoimmune hepatitis-primary biliary cholangitis overlap syndrome complicated by various autoimmune diseases:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1174-1181页

作者： Yu-Jie Qin Ting Gao Xing-Nian Zhou Ming-Liang Cheng Hong Li Clinical Medicine School of Guizhou Medical University Guiyang 550025Guizhou ProvinceChina Department of Pathology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Infectious Diseases Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Infectious Diseases Guizhou Provincial People's HospitalGuiyang 550025Guizhou ProvinceChina

BACKGROUND Autoimmune hepatitis(AIH)and primary biliary cholangitis(PBC)are two common clinical autoimmune liver diseases,and some patients have both diseases;this feature is called AIH-PBC overlap *** thyroid disease(AITD)is the most frequently overlapping extrahepatic autoimmune ***(IgG)4-related disease is an autoimmune disease recognized in recent years,characterized by elevated serum IgG4 levels and infiltration of IgG4-positive plasma cells in *** SUMMARY A 68-year-old female patient was admitted with a history of right upper quadrant pain,anorexia,and jaundice on physical *** examination revealed elevated liver enzymes,multiple positive autoantibodies associated with liver and thyroid disease,and imaging and biopsy suggestive of pancreatitis,hepatitis,and PBC.A diagnosis was made of a rare and complex overlap syndrome of AIH,PBC,AITD,and IgG4-related *** features improved on treatment with ursodeoxycholic acid,methylprednisolone,and *** This case highlights the importance of screening patients with autoimmune diseases for related conditions.

关键词： overlap syndrome Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis Autoimmune thyroid disease Case report

Primary Sclerosing Cholangitis and Primary Biliary Cirrhosis overlap syndrome:A Review

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 336-346页

作者： Sheena Mago George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Primary sclerosing cholangitis(PSC)and primary biliary cirrhosis(PBC)are slow progressive diseases which have been increasing in *** pathogeneses of PBC and PSC are incompletely understood but the underlying mechanisms appear to be fundamentally autoimmune in *** PBC and PSC appear to be separate entities,overlap has been *** depends on a combination of serological markers,imaging,and pathological *** mainstay of treatment has been ursodeoxycholic acid and in some cases of extrahepatic biliary obstruction and overlap disorder,endoscopic retrograde cholangiopancreatography has been useful.

关键词： Primary sclerosing cholangitis Primary biliary cirrhosis overlap syndrome

Clinical features of the overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis: retrospective study

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Chinese Medical Journal 2006年第3期119卷 238-241页

作者： WU Chi-hong WANG Qin-huan TIAN Geng-shan XU Xiao-yuan YU Yan-yan WANG Gui-qiang Department of Infectious Disease Peking University First HospitalBeijing 100034 China.

PBC-AIH overlap syndrome is an autoimmune liver disease between AIH （autoimmunehepatitis） and PBC （primary biliary cirrhosis）. To investigate the characteristic of the PBC-AIH ovedap syndrome, we have conducted a retrospective study of 12 diagnosed ovedap syndrome patients and compared them with typical PBC and AIH on the basis of clinical, biochemical, serological and histopathological findings.

关键词： primary biliary cirrhosi autoimmune hepatitis overlap syndrome clinical features

Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea syndrome:overlap syndrome

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Chronic Obstructive Pulmonary Disease and Obstructive Sleep ...

A serum metabolomic analysis for diagnosis and biomarker discovery of primary biliary cirrhosis and autoimmune hepatitis

中国睡眠研究会第十届全国学术年会

The coexistence of chronic obstructive pulmonary disease（COPD） and obstructive sleep apnea syndrome（OSA） is known as ‘overlap syndrome’.Globally,the incidence of overlap syndrome in individuals ＞ 40 years of age is estimated at 1%.Although COPD and OSA are pulmonary diseases with specific diagnoses they share similar features,including pathophysiology that involves airway obstruction and the inflammatory response,clinical characteristics,and treatment ***,clinicians lack awareness of these similarities and knowledge and vigilance in overlap *** reviews on overlap syndrome are scare,this article summarizes and discusses the literature on the pathogenesis and clinical characteristics of overlap syndrome to provide a reference for diagnosis and treatment of the disease.

关键词： chronic obstructive pulmonary disease obstructive sleep apnea syndrome overlap syndrome nocturnal hypoxemia

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 413-421页

作者： Jiang-Shan Lian Wei Liu Shao-Rui Hao De-Ying Chen Yin-Yin Wang Jian-Le Yang Hong-Yu Jia Jian-Rong Huang Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious Disease First Affiliated Hospital Zhejiang University School of Medicine Yantai City Hospital for Infectious Diseases

Because of the diversity of the dinical and laboratory manifestations, the diagnosis of autoimmune liver disease （AILD） remains a challenge in clinical practice. The value of metabolomics has been studied in the diagnosis of many diseases. The present study aimed to determine whether the metabolic profiles, based on ultraperformance liquid chromatography-mass spectrometry （UPLC-MS）, differed between autoimmune hepatitis （AIH） and primary biliary cir- rhosis （PBC）, to identify specific metabolomic markers, and to establish a model for the diagnosis of AIH and PBC. METHODS： Serum samples were collected from 20 patients with PBC, 19 patients with AIH, and 25 healthy individuals. UPLC-MS data of the samples were analyzed using principal component analysis, partial least squares discrimination analysis and or- thogonal partial least squares discrimination analysis. RESULTS： The partial least squares discrimination analysis model （R2y=0.991, Q2=0.943） was established between the AIH and PBC groups and exhibited both sensitivity and speci- ficity of 100%. Five groups of biomarkers were identified, in- eluding bile acids, free fatty acids, phosphatidylcholines, lyso- lecithins and sphingomyelin. Bile acids significantly increased in the AIH and PBC groups compared with the healthy con- trol group. The other biomarkers decreased in the AIH andPBC groups compared with those in the healthy control group. In addition, the biomarkers were downregulated in the AIH group compared with the PBC group. CONCLUSIONS： The biomarkers identified revealed the pathophysiological changes in AILD and helped to discrimi- nate between AIH and PBC. The predictability of this method suggests its potential application in the diagnosis of AILD.

关键词： autoimmune liver disease biomarkers metabolomics autoimmune hepatitis primary biliary cirrhosis overlap syndrome

高射流雾化面罩给氧在ICU患者中的应用效果观察

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中国实用护理杂志 2008年第8期24卷 20-21页

作者：白梅山东省聊城市中医医院一病房

传统ICU的给氧方式是采用鼻导管给氧,或是气管切开套管处导管给氧,但此种方法使给氧导管容易脱出,且易被污染。为此,2006年3月-2007年3月,我院采用高射流雾化面罩给氧代替鼻导管给氧,并观察其在ICU中的临床效果,发现其能有效湿化气道,... 详细信息

传统ICU的给氧方式是采用鼻导管给氧,或是气管切开套管处导管给氧,但此种方法使给氧导管容易脱出,且易被污染。为此,2006年3月-2007年3月,我院采用高射流雾化面罩给氧代替鼻导管给氧,并观察其在ICU中的临床效果,发现其能有效湿化气道,保持呼吸道通畅,提高吸氧效果,降低肺部感染,现报道如下。

关键词：射流雾化面罩给氧患者应用效果 overlap syndrome life style 鼻导管保持呼吸道通畅气管切开套管现报道如下吸氧效果湿化气道临床效果给氧方式肺部感染污染方法

Obstructive sleep apnea is associated with an increased prevalence of polycythemia in patients with chronic obstructive pulmonary disease

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Obstructive sleep apnea is associated with an increased prev...