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Reduction of Tat-interacting Protein 30 Expression Could be a Prognostic Marker in Bladder Urothelial Cancer

Chinese Medical Journal 2018年第2期131卷 188-193页

作者： Ye-Ping Li Jian-Fang Zhu Ka-TeHuang Rong-Rong Wang Bing Cai Hui Xie Hong-De Chen Department of Urology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 China Department of Vascular Surgery The Second Hospital of Shaoxing City Shaoxing Zhejiang 312000 China Department of Pathology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 China

Background： Tat-interacting protein 30 （TIP30） has been reported to be a tumor suppressor, with reduced or absent expression in various tumors. However, its role in bladder urothelial cancer （BUC） has not been investigated. Therefore, herein, we investigated the expression of T1P30 protein in BUC and normal bladder mucosa and the clinical significance of TIP30 expression in the prognosis of BUC. Methods： We reviewed data from 79 cases of BUC and 15 adjacent tissue samples from 79 patients treated at our institution between 2004 and 2007. TIP30 expression was examined by immunohistochemistry. The relationship between TIP30 expression and tumor stage, histological grade, and survival was analyzed. Differences between groups were evaluated using the t-test or matched-pairs test, and differences in the survival rates were analyzed with the log-rank test. Results： TIP30 protein expression was significantly reduced in BUC tissue （t = -6.91, P 〈 0.05） compared with normal tissue samples, and in invasive bladder cancer （t = 10.89, P 〈 0.05） compared with superficial bladder cancer. TIP30 protein expression differed significantly among different differentiated groups classified either according to the World Health Organization （2004, F = 17.48, P 〈 0.01） or World Health Organization （1973, F = 10.68, P 〈 0.01）. TIP30 protein expression was significantly reduced in high-grade papillary urothelial carcinoma compared with papillary urothelial neoplasm of low malignant potential （P 〈 0.05） and low-grade papillary urothelial carcinoma （P 〈 0.05）. Meanwhile, TIP30 protein expression was significantly reduced in Grade 111 BUC, compared with Grade I （P 〈 0.05） and Grade 11 （P 〈 0.05）. Patients with low T1P30 expression showed a higher incidence of disease progression than those with high TIP30 expression （t - 2.63, P 〈 0.05）. Kaplan-Meier survival analysis showed a strong positive relationship between TIP30 expression and overall survival （OS）（x^2 = 17.29, P 〈 0.05）. Conclusions： TIP30 expression was associated with clinical tum

关键词： Bladder Urothelial Cancer overall survival time Tat-interacting Protein 30

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Factors affecting the prognosis of children with medulloblastoma: A single institution retrospective analysis of 40 cases

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Translational Neuroscience and Clinics 2017年第1期3卷 16-27页

作者： Jianzhong Yu We Shi Hao Li Department of Neurosurgery Children's Hospital of Fudan University

Few studies have investigated the factors associated with the prognosis of children with medulloblastoma. This retrospective observational study evaluated the association of molecular subtype, clinical characteristics, and pathological types with the outcomes of children with medulloblastoma. This study included 40 patients with medulloblastoma who underwent surgical resection at the Affiliated Children's Hospital of Fudan University between January 2004 and June 2014. The primary outcome was overall survival(OS). Risk factors associated with survival, disease progression, and recurrence were analyzed by univariate Cox regression analysis; the identified significant risk factors were further analyzed by Kaplan-Meier survival curves. Immunohistochemistry analysis of Yes-associated protein 1(YAP1) and GRB2-associated protein 1(GAB1) was used for medulloblastoma subtype identification; 20% of tumors were the WNT subtype, and 32.5% were the SHH subtype, with the remainder being non-SHH/WNT.Factors associated with OS included M stage, calcification, cerebrospinal fluid fistula,postoperative treatment(radiotherapy, chemotherapy, or both), postoperative Karnofsky Performance Scale score, and molecular subtype(P survival outcomes(hazard ratio [HR] = 0.16, 95% confidence interval[CI]: 0.05–0.58). Number of symptoms, M stage, and postoperative radiotherapy were associated with disease progression(P ≤ 0.033). The risk of recurrence increased with advanced M stage(HR = 30.71; 95% CI: 3.92–240.44, P = 0.001). Patients receiving both chemotherapy and radiotherapy were less likely to have a recurrence(P = 0.040).Molecular subtyping of medulloblastoma was more predictive of survival than histopathology in patients undergoing adjuvant therapy.

关键词： child medulloblastoma clinical factors molecular phenotype overall survival time prognosis

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