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Application progress of acupuncture in treatment of ovarian hypofunction

TMR Non-Drug Therapy 2021年第3期4卷 18-23页

作者： Jing-Yu Xu Yi-Hua Fan Jun-Ze Geng Na Gao Feng-Hua Yu Tian Xia First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China Tianjin University of Traditional Chinese Medicine Tianjin301617China

The decline of ovarian reserve is an important cause of female *** and more older women want to be pregnant again,especially because of the liberal birth *** the main reason for limiting fertility in older women is the decline of ovarian *** the same time,due to the change of social environment,the incidence of ovarian function decline has a trend of ***,in the infertile women,ovarian dysfunction was found to account for a higher *** ways to improve ovarian function is especially important for improving female *** medicine has no clear treatment for the disease,only some health products such as coenzyme Q10,dehydroepiandrosterone are used to maintain the *** a simple and convenient non-drug therapy,acupuncture has been widely used in improving the ovarian function of infertile women in recent years,and its effect has been explored by many ***,this article will start from the human body research and the animal experiment two aspects,discusses the acupuncture improvement ovary function.

关键词： Acupuncture ovarian hypofunction Infertility Application

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Effect of Mushroom Extract Hericium erinaceus on Spatial Memory and Morphology of Neurons in the CA1 and CA3 Regions of the Hippocampus in Ovariectomized Rats

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Open Journal of Veterinary Medicine 2024年第7期14卷 163-179页

作者： Lucia Garcia-Delgado Mariana Monserrath Verdía-Venegas Jacinto Bañuelos-Pineda Esther Albarrán-Rodríguez Guillermo Nolasco-Rodriguez José Ricardo Cuellar-Pérez Sergio Fausto-Guerra Manuel Rosales-Cortés Master in Behavioral Sciences Institute of Neurosciences University of Guadalajara Zapopan Mexico Department of Veterinary Medicine Division of Veterinary Sciences CUCBA University of Guadalajara Zapopan Mexico Botany and Zoology Laboratory CUCBA University of Guadalajara Zapopan Mexico

Various studies indicate that low levels of estradiol negatively impact cognitive abilities. Extracts from the fungus Hericium erinaceus (HE) contain bioactive components that promote the proper functioning of the nervous system and potential effects on protection against neurodegenerative diseases, including dementia and motor dysfunctions. The objective was to evaluate the effects of the administration of the HE mushroom extract on visuospatial memory and morphology of neurons in the CA1 and CA3 regions of the hippocampus in ovariectomized rats. 40 young Wistar rats weighing 90 ± 10 g BW were used, which were distributed into four groups of 10 animals;Control Group, non-ovariectomized and untreated rats;Group E2, ovariectomized rats treated with estradiol (2 μg/kg/body weight);Group HE, ovariectomized rats treated with the extract of the fungus Hericium erinaceus (0.5 mg/kg body weight) and Group Ovx/ST, ovariectomized rats, without treatment. The animals were tested in the Barnes and Open Field maze, then they were sacrificed, and their brains were obtained to perform a histological analysis of neuronal morphology in the CA1 and CA3 areas of the hippocampus. The most outstanding results showed that the Ovx/ST group recorded the longest time to arrive at the escape box and stay in the Barnes maze. A correlation was observed between neuronal damage and function;in the groups that did not present satisfactory performance in the maze tests, morphological alterations were identified such as the presence of some neuronal somata with degeneration characteristics such as pyknosis, nuclear basophilia and shrinkage of the cells. Its soma, as well as a decrease in the nuclear area of CA1 and CA3 neurons. It is concluded that the fungus Hericium erinaceus exerted a neuroprotective effect on the neuronal bodies of the hippocampus, associated with better performance in the visuospatial recognition memory test.

关键词： Ovariectomized Rats ovarian hypofunction Estradiol Hericium erinaceus Barnes Circular Labyrinth Open Field Labyrinth

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