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Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish

Zoological Research 2024年第4期45卷 791-804页

作者： Wen-Hao Li Zhi-Qiang Li Meng-Di Bu Jia-Zhen Li Liang-Biao Chen Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China International Research Center for Marine Biosciences Ministry of Science and TechnologyCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China

As ectotherms, fish are highly sensitive to temperature fluctuations, which can profoundly impact their reproductive cycles. In this study, we investigated the fertility and histological characteristics of zebrafish(Danio rerio) ovaries exposed to a temperature gradient ranging from the thermopreferendum temperature of the species,27℃, to lower temperatures of 22℃, 20℃, and 13℃ over a period of two weeks. Comparative metabolomic(six biological replicates for each temperature) and transcriptomic(four biological replicates for each temperature) analyses were conducted under the four temperature conditions. Results indicated that lower temperatures inhibited oocyte development and differential metabolites were involved in steroid hormone production,antioxidant function, and lipid and protein *** reproductive hormones, increased proteolysis,and lipid degradation significantly impeded oocyte development and egg maturation. Notably, a significant increase in bile acid content was noted in the ovaries of the cold-treated fish, indicating that bile acids play a critical role in ovarian failure. Overall, these findings provide valuable insights into the mechanisms governing the reproductive response of fish to cold stress.

关键词： old stress ovarian failure Metabolome Zebrafish

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Distribution of CD 4^+ Lym phocyte Th1/Th2 Subsets in Peripheral Blood of Women with Idiopathic Prem ature ovarian failure

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Journal of Reproduction and Contraception 1999年第1期10卷 7-11页

作者： YANGGui-yan(杨桂艳) WANGYi-li(王一理) CAO Zan-sun(曹瓒孙) LI-Xu(李旭) Departm entof Obstetrics & Gynecology, FirstTeaching Hospital Institute of Im m unopatholgy Xian MedicalUniversity, Xian 710061, China DepartmentofObstetrics＆Gynecology FirstTeachingHospitalXianMedicalUniversityXian710061China

Thepathogenesisof prem ature ovarian failure (POF) rem ains unknow n. Accu- m ulated evidences indicate that abnorm ality in the im m une system m ay be one of the m ajor reasonsand theim balanceof Thelp typeI(Th1) and Thelp typeII(Th2) m ay play an importantrolein theprocess. Study of thedistribution and functionalstatusof Th1/Th2 m ay behelpfulforevaluating thepathogenesisof POF.13 patientsw ith id- iopathic POFand 7 w om en of reproductiveagew ith norm alcyclew ereenrolled in this *** percentage of Th1 and Th2 cellsfrom peripheralblood of thepatientsand the controls w as studied using FITC labelled CD4 m Ab to separate CD4+ cells by FACS, in com bination w ith in situ hybridization using Dig-labelled IL2, IL6 cDNA ***:The patients w ith POF had significantly higher percentage of Th1 cellsascompared w ith the controls(49.76±9.22,20.06±7.10respectively, P< 0.001).The ratio of Th1/Th2 in thepatientsw ith POFw assignificantly higherthan thatof thecontrols(1.15±0.17, 0.63±0.09, P< 0.001). Conclusions: Thefindings of thisstudy suggestthatpatientsw ith POFhaveincreased Th1 cellactivation, w hich m ay be related to the pathogenesisof POF. Corresponding author: WANG Yi-li E-m ail: w yl@ irix. xam u. edu. cn

关键词： Prem ature ovarian failure Tlym phocyt

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Infertility and ovarian failure in celiac disease

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World Journal of Obstetrics and Gynecology 2015年第4期4卷 72-76页

作者： Hugh James Freeman Department of Medicine(Gastroen- terology) University of British Columbia

Unexplained infertility in females may be a devastating event for the reproductive-aged ***,infertility may be due to ovarian failure associated with celiac disease,an immune-mediated disorder that may have few or no symptoms and can be successfully *** some prospective serologically-based studies,over 4% of infertile females may prove to have celiac *** screening for celiac disease is relatively inexpensive and involves testing for antibodiesto tissue *** positive,a small intestinal biopsy should be done to confirm the *** initial treatment for this disorder is a gluten-free *** date,a number of reports have indicated that this treatment for celiac disease may result in successful pregnancy,in spite of prolonged periods of *** disease,when untreated,may also lead to several adverse events following pregnancy including increased risk of recurrent abortions,low birthweight and impaired fetal *** molecular and pathological studies from different laboratories suggest that altered placental function may be due to binding to cells in the trophoblast by tissue transglutaminase antibodies impairing embryo implantation and leading to failure of early pregnancy or retarded intrauterine growth.

关键词： Celiac disease Infertility ovarian failure Autoimmune disease Polyglandular syndrome

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