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Relationships among magnetic resonance imaging, histological findings, and IGF-I in steroid-induced osteonecrosis of the femoral head in rabbits

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第9期9卷 739-746页

作者： Xing-can CHEN1,2, Jian WENG1, Xue-qun CHEN1, Ji-zeng DU1, Miao-ping ZHU2, Yong-qing PAN2, Miao LIU2 (1Division of Neurobiology and Physiology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou 310058, China) (2Department of Radiology, the 117 Hospital of the Chinese People’s Liberation Army, Hangzhou 310013, China) Division of Neurobiology and Physiology Institute of Neuroscience School of Medicine Zhejiang University Hangzhou 310058 China. genius1174@***

Objective: To study the relationships among magnetic resonance imaging (MRI), histological findings, and insu- lin-like growth factor-I (IGF-I) in steroid-induced osteonecrosis of the femoral head in rabbits. Methods: Thirty rabbits were randomly divided into experimental Group A (n=15) and control Group B (n=15). The 7.5 mg/kg (2 ml) of dexamethasone (DEX) and physiological saline (2 ml) were injected into the right gluteus medius muscle twice at one-week intervals in animals of Groups A and B, respectively. At 4, 8 and 16 weeks after obtaining an MRI, the rabbits were sacrificed and the femoral head from one side was removed for histological study of lacunae empty of osteocytes, subchondral vessels, and size of fat cells under microscopy, and the femoral head from the other side was removed for enzyme-linked immunoadsorbent assay (ELISA) for IGF-I. Results: At 4, 8 and 16 weeks after treatment, no necrotic lesions were detected in Group B, while they were detected in Group A. Light microscopy revealed that the fat cells of the marrow cavity were enlarged, subchondral vessels were evidently decreased, and empty bone lacunae were clearly increased. The IGF-I levels in Group A were significantly higher than those in Group B. At 8 weeks after the DEX injection, the MRI of all 20 femora showed an inhomogeneous, low signal intensity area in the femoral head, and at 16 weeks, the findings of all 10 femora showed a specific "line-like sign". The MRI findings of all femora in Group B were normal. Conclusion: MRI is a highly sensitive means of diagnosing early experimental osteonecrosis of the femoral head. However, the abnormal marrow tissues appeared later than 4 weeks when the expression of IGF-I increased. This reparative factor has an early and important role in response to steroid-induced osteonecrosis of the femoral head, and provides a theoretical foundation for understanding the pathology and designing new therapies.

关键词： Dexamethasone (DEX) Insulin-like growth factor-I (IGF-I) Magnetic resonance imaging (MRI) osteonecrosis of the femoral head Pathology

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Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head

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Neural Regeneration Research 2022年第4期17卷 806-811页

作者： Jie Ma Xu-Yun Hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Sheng-Yi Feng Bo Li Jian-Guang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina

Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the ***,most studies are volume-based which may lead to inaccurate anatomical positioning of functional *** methods that work on the cortical surface may be more sensitive than those using the full brain volume and thus be more suitable for map plasticity *** this prospective cross-sectional study performed in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,20 patients with osteonecrosis of the femoral head(12 males and 8 females,aged 56.80±13.60 years)and 20 healthy controls(9 males and 11 females,aged 54.56±10.23 years)were included in this *** of resting-state functional magnetic resonance imaging were *** results revealed that compared with healthy controls,compared with the healthy controls,patients with osteonecrosis of the femoral head(ONFH)showed significantly increased surface-based regional homogeneity(Re Ho)in areas distributed mainly in the left dorsolateral prefrontal cortex,frontal eye field,right frontal eye field,and the premotor cortex and decreased surface-based Re Ho in the right primary motor cortex and primary sensory *** showing significant differences in surfacebased Re Ho values between the healthy controls and patients with ONFH were defined as the regions of ***-based functional connectivity was performed to investigate interregional functional *** the areas with decreased surface-based Re Ho in the frontal eye field and right premotor cortex were used as the regions of interest,compared with the healthy controls,the patients with ONFH displayed increased functional connectivity in the right middle frontal cortex and right inferior parietal cortex and decreased functional connectivity in the right precentral cortex and right middle occipital ***

关键词： cortical thickness functional connectivity hip disorder osteonecrosis of the femoral head Re Ho sensorimotor cortex surface-based map plasticity volume of subcortical gray matter nuclei

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Gene testing for osteonecrosis of the femoral head in systemic lupus erythematosus using targeted next-generation sequencing:A pilot study

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World Journal of Clinical Cases 2020年第12期8卷 2530-2541页

作者： Hong-Sheng Sun Qing-Rui Yang Yan-Yan Bai Nai-Wen Hu Dong-Xia Liu Cheng-Yong Qin Department of Rheumatology and Immunology Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Previous publications indicated that genetic predisposition might play important roles in the onset of osteonecrosis of the femoral head(ONFH)in systemic lupus erythematosus(SLE).Some gene loci such as complement C3d receptor 2(CR2),nitric oxide synthase 3(NOS3),collagen type II alpha 1 chain(COL2A1),protein tyrosine phosphatase non-receptor type 22(PTPN22),and transient receptor potential cation channel subfamily V member 4(TRPV4)were reported to be involved in this *** To investigate whether the risk of ONFH in SLE is associated with single nucleotide variations(SNVs)in these five *** SNVs in the CR2,NOS3,COL2A1,PTPN22,and TRPV4 genes were examined by using FastTarget and Illumina Miseq sequencing technologies in 49 cases of SLE with ***–wheeler aligner was used to align the sequencing reads to hg19,and GATK and Varscan programs were used to perform SNV ***-2,SIFT,and MutationTaster were used to assess the functional effects of non-synonymous *** Six of the 49 patients were confirmed to have low frequency SNVs,including one patient with SNVs in NOS3(exon 6:c.814G>A:p.E272K and exon 7:c.814G>A:p.E272K.),four in COL2A1(rs41263847:exon 29:c.1913C>T:p.T638I,exon 28:c.1706C>T:p.T569I,and rs371445823:exon 8:c.580G>A:p.A194T,exon 7:c.373G>A:p.A125T),and one in CR2(rs45573035:exon 2:c.200C>G:p.T67S).CONCLUSION The onset of ONFH in SLE might be associated with the identified SNVs in NOS3,COL2A1,and CR2.

关键词： Single nucleotide variations osteonecrosis of the femoral head Systemic lupus erythematosus Nitric oxide synthase 3 Collagen type II alpha 1 chain Complement C3d receptor 2

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osteonecrosis of the femoral head:Involvement of Anterolateral Portion Related to Development of Collapse

Osteonecrosis of the femoral head:Involvement of Anterolater...

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第二十四届中国中西医结合骨伤科学术年会

作者： Wei Qiushi Chen Zhenqiu Zhang Qingwen He Wei Hip preserving ward No.3 Orthopaedic regionThe First Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Orthopaedics First Affiliated Hospital of Guangzhou University of Chinese Medicine

Objective We investigated the relationship between the bone preservation of weight-bearing area and collapse progression in necrotic femoral *** 87 patients(102 hips)with Association Research Circulation Osseous(ARCO)stage-Ⅱosteonecrosis of the femoral head(ONFH),diagnosed by magnetic resonance imaging(MRI),were involved in the *** patients underwent a natural *** and bone involvement of the weight-bearing area were viewed by anteroposterior and frog-leg lateral *** to the location of the necrotic lesion on the anterolateral portion of the femoral head,the necrosis was divided into 3 types:necrosis involves 1,the posteromedial and central portions;2,part of the anterolateral portion;3,the entire anterolateral *** collapse rate and the time to collapse in different types were *** Of the 60 hips with collapse,in 46/60(76.7%)hips collapse was identified on anteroposterior radiograph,however,on frog-leg lateral radiograph showing collapsed femoral head could be identified in 57/60(95.0%)hips,which was statistically significant(Pfemoral head.

关键词： osteonecrosis of the femoral head Collapse frog-leg lateral radiograph Relation

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Pericollapse Stage of osteonecrosis of the femoral head： A Last Chance for Joint Preservation

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Chinese Medical Journal 2018年第21期131卷 2589-2598页

作者： Qing-Yu Zhang Zi-Rong Li Fu-Qiang Gao Wei Sun Department of Orthopaedic Graduate School of Peking Union Medical College China-Japan Friendship Hospital Institute of Clinical Medicine Beijing 100029 China Department of Orthopaedic Centre for Osteonecrosis and Joint-Preserving and Reconstruction China-Japan Friendship Hospital Beijing 100029 China Department of Orthopaedic Peking University China-Japan Friendship School of Clinical Medicine Beijing 100029 China

Objective： To propose a new definition of the pericollapse stage of osteonecrosis of the femoral head （ONFH） and review its significance in disease diagnosis and treatment selection. Data Sources： A search for eligible studies was conducted in three electronic databases including PubMed, Cochrane Library, and Embase up to August 10, 2018, using the following keywords：＂osteonecrosis＂, ＂prognosis＂, and ＂treatment＂. Study Selection： Investigations appraising the clinical signs, symptoms, and imaging manifestations in different stages of ONFH were included. Articles evaluating the prognosis of various joint-preserving procedures were also reviewed. Results： The pericollapse stage refers to a continuous period in the development of ONFH from the occurrence of subchondral fracture to early collapse （〈2 mm）, possessing specific imaging features that mainly consist of bone marrow edema and joint effusion on magnetic resonance imaging （MR1）, crescent signs on X-ray films, and clinical manifestations such as the sudden worsening of hip pain. Accumulating evidence has indicated that these findings may be secondary to the changes after subchondral fractures. Of note. computed tomography provides more information for identifying possible subchondral fractures than does MRI and serves as the most sensitive tool for grading the pericollapse lesion stage. The pericollapse stage may indicate a high possibility of progressive disease but also demonstrates satisfactory long- and medium-term outcomes fbr joint-preserving techniques. In tact, if the articular surface subsides more than 2 mm, total hip arthroplasty is preferable. Conclusions： The pericollapse stage with distinct clinical and imaging characteristics provides a last good opportunity for the use of joint-preserving techniques. It is necessary to separate the pericollapse stage as an independent state in evaluating the natural progression of ONFH and selecting an appropriate treatment regimen.

关键词： Joint-Preserving Procedure osteonecrosis of the femoral head Pericollapse Prognosis

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Early Outcomes of Primary Total Hip Arthroplasty for osteonecrosis of the femoral head in Patients with Human Immunodeficiency Virus in China

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Chinese Medical Journal 2015年第15期128卷 2059-2064页

作者： Chang-Song Zhao Xin Li Qiang Zhang Sheng Sun Ru-Gang Zhao Juan Cai Department of Orthopedics Beijing Ditan Hospital Capital Medical University Beijing 100015 China

Background：Studies have reported that patients with human immunodeficiency virus （HIV） have a high incidence of osteonecrosis of the femoral head （ONFH）.Total hip arthroplasty （THA） is an effective management of ***,little data exist regarding the use of THA for the HIV patients with ONFH in *** study reviewed the outcomes of HIV-positive patients who underwent THA for ONFH,compared with HIV-negative ***：The patients who underwent THA for ONFH from September 2012 to September 2014 in Beijing Ditan Hospital,Capital Medical University were retrospectively ***-eight HIV-positive patients and 35 HIV-negative patients underwent 48 THAs and 45 THAs with cementless components,*** records and follow-up data were *** Hip Score （HHS） was applied to evaluate the pain and function of the hips before and after *** such as wound healing,surgical site infection,deep venous thrombosis,pulmonary embolism,sepsis,mortality,and complications from the prosthesis were *** operation time,blood loss,and hospital stay were compared between the two ***：The mean follow-up period was 19.5 ± 5.8 months （ranging from 6 to 30 months）.The mean age of the HIV-positive patients with osteonecrosis at the time of surgery was 35 years old,which was significantly lower than that of the HIV-negative group （42 years old）（P 〈 0.05）.The HIV-positive patients underwent surgery a mean of 2.5 years after their original symptoms,which was significantly shorter than the HIV-negatives＇（mean 4 years）（P 〈 0.05）.Among HIV-positive patients,the prevalence of being male and rate of bilateral procedures were significantly higher than those in the HIV-negative group （P 〈 0.05）.The operation time in HIV-positive patients was significantly longer than that in HIV-negative patients （P 〈 0.05）.There were no significant differences in blood loss or hospital stay between the two groups （P 〉 0.05）.The HHSs of two groups

关键词： Arthroplasty Harris Hip Score Hip Human Immunodeficiency Virus Infections osteonecrosis of the femoral head Outcomes

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Effect of superior retinacular artery damage on osteonecrosis of the femoral head

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Chinese Medical Journal 2013年第20期126卷 3845-3850页

作者： Liu Bao-yi Zhao De-wei Yu Xiao-bing Yang Lei Guo Lin Wang Ben-jie Southern Med Univ Dept Clin Anat Guangzhou 510515 Guangdong Peoples R China Dalian Univ Zhongshan Hosp Dept Orthoped Dalian 116001 Liaoning Peoples R China

Background osteonecrosis of the femoral head （ONFH） is the result of dysfunctional blood supply, but associations between specific damaged arteries, imaging changes and clinical sign require more understanding. We investigated characteristics of ONFH that pertain to blood supply, imaging appearance, and clinical feature to judge the prognosis of ONFH.

关键词： osteonecrosis of the femoral head " blood supply " digital subtraction an^io^raphv

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Effect of HuoguⅡFormula(活骨Ⅱ方) with Medicinal Guide Radix Achyranthis Bidentatae on Bone Marrow Stem Cells Directional Homing to Necrosis Area after osteonecrosis of the femoral head in Rabbit

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Chinese Journal of Integrative Medicine 2012年第10期18卷 761-768页

作者：孔祥英王荣田田能李莉林娜陈卫衡 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Wangjing Hospital China Academy of Chinese Medical Sciences

Objective： To investigate the effect of Huogu II Formula （活骨 II方） with medicinal guide Radix Achyranthis Bidentatae （Ach） on bone marrow stem cells （BMSCs） homing to necrosis area after osteonecrosis of the femoral head （ONFH） frozen by liquid nitrogen in rabbit as well as to explore the mechanism of prevention and treatment for ONFH. Methods： The animal model of ONFH was established by liquid nitrogen frozen on the rabbit left hind leg. Forty-eight Japanese White rabbits were randomly assigned to sham-operated group, model group, Huogu II group, and Huogu II plus Ach group, with 12 rabbits in each. During the course of ONFH animal model establishment, all rabbits were subcutaneously injected with recombinant human granulocyte colony-stimulating factor [rhG-CSF, 30 μg/（***） for continuous 7 days]. Meanwhile, normal saline and decoction of the two formulae were administrated by gavage, respectively. White blood cells （WBC） were counted in peripheral blood before and after injection of rhG-CSF. Materials were drawn on the 2rid and 4th weeks after model built; bone glutamine protein （BGP） and bone morphogenetic protein 2 （BMP2） levels in serum were tested. Histopathologic changes were observed by hematoxylin and eosin （HE） staining. BMP2 mRNA levels were detected with in situ hybridization （iSH） staining. 5-Bromo-2＇-deoxyuridine （BrdU） and stromal cell derived factor 1 （SDF-1） were measured by immunohistochemical assay in femoral head of the left hind leg. Results： Compared with the shamoperated group, the ratio of empty lacuna, serum BGP, and SDF-1 level in the model group increased significantly, and BMP2 in both serum and femoral head decreased significantly. However, in comparison with the model group, the empty lacuna ratio of Huogu II group and Huogu II plus Ach group decreased obviously in addition to the levels of serum BGP and BMP2, and the expressions of BMP2 mRNA, BrdU, and SDF-1 increased significantly. Above changes were particularly obvious in Huogu I

关键词： osteonecrosis of the femoral head bone marrow stem cells homing guide drug to affected area

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Surgical Treatment of osteonecrosis of the femoral head Using Minimally Invasive Surgical Drilling and Cancellous Grafting at Brazzaville University Hospital

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Open Journal of Orthopedics 2024年第2期14卷 122-132页

作者： Kevin Parfait Bienvenu Bouhelo-Pam Marius Monka Arnauld Sledje Wilfrid Bilongo Bouyou Regis Perry Massouama Paul Yèlai Ikounga Roger Bertrand Sah Mbou Armand Moyikoua Department of Orthopaedic surgery and Traumatology University Hospital of Brazzaville Brazzaville Republic of the Congo Faculty of Health Sciences Marien N’GOUABI University Brazzaville Republic of the Congo

Introduction: osteonecrosis of the femoral head (ONTF) is a debilitating condition. Several treatments have been proposed with controversial results. The aim of our study was to evaluate treatment by surgical drilling coupled with in situ cancellous grafting. Materials and methods: Our study was a case-control study conducted at Brazzaville University Hospital from 1st January 2018 to 31 December 2023. It compared two groups of patients with ONTF: non-operated (13 patients, 20 hips) and operated (22 patients, 35 hips). We used the visual digital scale (VDS) for pain assessment, the Merle D’Aubigne-Postel (MDP) scoring system for clinical and functional assessment, and the evolution of necrosis. Results: The group of non-operated patients had a mean age of 35.69 ± 3.4 years, no improvement in pain with an EVN above seven at the last recoil and a mean global MDP score falling from 12.7 before offloading to 10.13 at one year. The group of patients operated on had a mean age of 37.86 ± 7.02 years, a significant reduction in pain (p = 0.00004) and a significantly increased MDP score (p = 0.0034). A comparison of the two groups of patients showed significant stabilization of the necrotic lesions in the operated patients (p = 0.00067), with better satisfaction in the same group. Conclusion: Surgical drilling combined with grafting in the treatment of early-stage ONTF has improved progress in our series. The technique is reproducible and less invasive. It has made it possible to delay unfavorable progression and, consequently, hip replacement surgery.

关键词： Hip osteonecrosis of the femoral head Conservative Treatment Surgical Drilling Bone Grafting

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Research progress of microRNA in prevention and treatment of osteonecrosis of the femoral head

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TMR Clinical Research 2018年第2期1卷 68-76页

作者： Changsui Yu Liguo Zhu Xiaofeng Zhang ZhongbaoYu Fengyuan Zhan Shuren Wang Xilin Xu Zhengchun Wang Jun Zhao Xinsheng Xie Wangjing Hospital China Academy of Chinese Medical SciencesGraduate SchoolBeijingChina Zhong-bao Yu of Chinese medicine clinic KuandianLiaoningChina First Hospital Affiliated to Heilongjiang University HaerbinHeilongjiangChina Department of Orthopedics the Second Hospital Affiliated to Heilongjiang UniversityHaerbinHeilongjiangChina Heilongjiang University of Chinese Medicine HaerbinHeilongjiangChina

In the 1980s,Feinbaum et *** discovered miRNA in the development of worms and termed it as *** the development of microbial science and continuous improvement in the gene sequencing technology,miRNA has been gradually gaining attention for intensive research in clinical *** these,one group of miRNAs has been confirmed to play fundamental roles in gene regulation in various orthopedics diseases,such as bone tumors,osteoarthritis,and rheumatoid *** study of miRNAs in the osteonecrosis of the femoral head(ONFH)can improve the understanding of the pathogenesis of the *** is an orthopedic disease that is the primary cause of disrupted blood supply to the femoral head and the main symptoms of bone and muscle *** studies showed that miRNA played a major role in the regulation of the microcirculation of ONFH,damage and repair of blood vessels,local microcirculation dysfunction caused by other diseases,and apoptosis of bone *** this study,recent related research results of miRNA and ONFH were analyzed and summarized,and the prospective in the prevention and treatment of the disease was also discussed.

关键词： MicroRNA osteonecrosis of the femoral head Expression and function Prevention and treatment Review

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