检索结果-南通市图书馆

Downregulation of orosomucoid 2 acts as a prognostic factor associated with cancer-promoting pathways in liver cancer

引用

World Journal of Gastroenterology 2020年第8期26卷 804-817页

作者： Han-Zhang Zhu Wei-Jiang Zhou Ya-Feng Wan Ke Ge Jun Lu Chang-Ku Jia Department of Hepatopancreatobiliary Surgery Hangzhou First People’s HospitalThe Affiliated Hospital of Medical School of Zhejiang University

BACKGROUND Liver cancer has a high mortality and morbidity rate throughout the *** clinical practice,the prognosis of liver cancer patients is poor,and the complex reasons contribute to treatment failures,including fibrosis,hepatitis viral infection,drug resistance and ***,screening novel prognostic biomarkers is of great importance for guiding liver cancer *** genes(ORMs)encode acute phase plasma proteins,including orosomucoid 1(ORM1)and *** studies showed their upregulation upon inflammation,but the specific function of ORMs has not yet been determined,especially in the development of liver *** To determine the expression of ORMs and their potential function in liver *** Analysis of the expression of ORMs in different human tissues was performed on data from the HPA RNA-seq normal tissues *** expression ratio of ORMs was determined using the HCCDB database,including the ratio between liver cancer and other cancers,normal liver and other normal tissues,liver cancer and adjacent normal liver *** of ORM expression in different cancer types was performed using The Cancer Genome Atlas and TIMER *** expression of ORMs in liver tumor tissues and adjacent normal tissues were further confirmed using gene Expression Omnibus data,including GSE36376 and *** 10-year overall survival(OS),progression-free survival(PFS)and relapse-free survival(RFS)rates between high and low ORM expression groups in liver cancer patients were determined using the Kaplan-Meier plotter *** Set Enrichment Analysis(GSEA)was employed to explore the ORM2-associated signaling *** between ORM2 expression and tumor purity or the infiltration level of macrophages in liver tumor tissues were determined using the TIMER *** correlation between ORM2 gene levels,tumor-associated macrophage(TAM)markers(including CD68 and TGFβ1)and T cell immunosuppression(including CTLA4 and PD-1)in

关键词： orosomucoid gene Specific expression Downregulation Prognostic factor Tumor promoter signaling Immune suppression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：