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Convenient Synthesis of Host Molecule Containing Se-Se Bond

Chinese Chemical Letters 1998年第9期9卷 813-814页

作者： Wei Jun KE Xiu Fang LIU Han Shang XU (Institute of Chemistry, Wuhan University, Wuhan 430072) Institute of Chemistry Wuhan University Wuhan 430072 China

Key intermediate bis[2-amino-4,5-(15-crown-5)phenyl]diselenide was obtained by the convenient redox method. Crown-ether type host molecule containing Se-Se bond 2,11-dioxo-4,5:8,9-di(benzo[4',5']-15-crown-5)-6,7-diselena-3,10,16-triazabicyclo[10,3,1]hexadeca-1(16), 4, 8, 12, 14-pentaene was synthesized with high dillution technique.

关键词： host molecule organoselenium oxidation and reduction high dilution technique

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A Convenient Preparation of N-Alkyl-2,5-dihydroisoxazoles from O-Allyl Oximes

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Chinese Journal of Chemistry 2004年第10期22卷 1192-1195页

作者：汤峨林向进黄宪 Department of Chemistry Zhejiang University (Xixi Campus) State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

The organoselenium-induced ring-closure reaction of O-allyl oximes gave cyclic iminium salts, which reacted with Grignard reagents to produce N-alkyl-4-phenylselenoisoxazolidines. 2,5-Dihydroisoxazoles could be obtain... 详细信息

关键词： organoselenium O-allyl oximes 2,5-dihydroisoxazole selenoxide syn-elimination intramolecular cyclization

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Different responses of HepG2 subclones to low dose ethaselen

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Journal of Chinese Pharmaceutical Sciences 2016年第4期25卷 302-309页

作者：张国州熊堃马薇薇徐伟曾慧慧北京大学医学部药学院化学生物学系天然药物及仿生药物国家重点实验室北京100191

As a synthesized antineoplastic organoselenium compound, ethaselen is known to induce apoptosis in tumor cells via dose-dependent thioredoxin reductase （TrxR） inhibition. Thioredoxin, the multifunctional biological substrate of TrxR, is then left in the oxidized state, which subsequently leads to intracellular accumulation of reactive oxygen species （ROS）, cell cycle arrest and/or apoptosis. However, the low dose effect of ethaselen remains largely unknown. Several subclones have been derived from HepG2 cells by using single cell or colony isolation. The low dose of ethaselen was defined as the drug concentration of retaining 〉90% HepG2 cells alive. The HepG2 cells were used as reference of its subclones （SM01, SM02 and SM03）, and the cell cycle transition, intracellular proteins change, colony formation and sphere growth were assayed in treatment of low dose ethaselen. HepG2 and its subclones differently responded to lethal dose of cisplatin or 5-fluorouracil. Low dose of ethaselen （1 μm） modulated the cell cycle transition at 12 h of treatment, but ceils were partially recovered at 24 h of treatment though some proteins were still affected. Low dose of ethaselen did not inhibit the small colony （diameter 〉 100 μm） formation and sphere growth of HepG2 and SM01. However, low dose of ethaselen could specifically inhibit the survival, large colony （diameter 〉500 μm） formation and sphere growth of SM03, although SM03 could be rapidly recovered from ethaselen-induced cell cycle check. HepG2 and its subclone cells could survive but respond differently to treatment of low dose ethaselen （1 μM）. Low dose of ethaselen could significantly inhibit a HepG2 subclone （SM03） in cell survival and colony growth.

关键词： Low dose organoselenium Ceil subcloning Heterogeneity Tumor cell

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Effects of Selenium-Enriched Probiotics on Semen Quality of Stock Boars

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Animal Husbandry and Feed Science 2010年第2期2卷 5-7页

作者： SU Hui-long LI Ru-shu HE Xiang-ren CHEN Jin-zhen HAN Zhuo-zhou LIU Yu ZHANG Jian-fei Zhuhai Entry-Exit Inspection and Quarantine Bureau of P. R. C Zhuhai 519015 China Institute of Veterinary Medicine Guangdong Acad- emy of Agricultural Sciences and Guangdong Common Lab of Veterinary Public Health Guangzhou 510640 China Zhuhai Epidemic Pre- vention and Supervision Center for Animals and Plants Zhuhai 519000 China Breeding Pig Farm of Guangdong Province Guangzhou 510520 China College of Veterinary Medicine Southern China Agricultural University Guangzhou 510642 China

Selenium-enriched probiotics were supplemented into feedstuff of Landrace stock boars at a concentration of 0.3 mg/kg （concentration of selenium）, and the semen quality of the stock boars were observed. The results showed that the semen motility, rate of intact acrosome, and activity of glutathione peroxidase were higher in the experimental boars than in the control, but rate of sperm deformity was lower in the experimental boars than in the control. Therefore, the selenium-enriched probiotics greatly improve semen quality of stock boars.

关键词： organoselenium Probiotics Stock boars Semen quality

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