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Relationship between Acute organophosphorus pesticide poisoning and Damages Induced by Free Radicals

Biomedical and Environmental Sciences 2002年第2期15卷 177-186页

作者： ZHOU JUN-FU XU GEN-BO FANG WEI-JUN SecondAffiliatedHospitalofCollegeofMedicine ZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangProvinceChina

To study the relationship between abnormal reactions of free radicals in bodies of patients with acute organophosphorus pesticide poisoning (AOPP) and damages induced by free *** 58 AOPP patients and 58 healthy adult volunteers(HAV)were enrolled in an independent samples control design,in which spectrophotometric methods were used to determine the concentrations of nitric oxide(NO)and lipoperoxides(LPO)in plasma,and LPO in erythrocytes,vitamin C (VC),vitamin E(VE)and β-carotene (β-CAR)in plasma as well as activities of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px)and acetylcholiesterase(AChE) in ***:Compared with the average values of every biochemical parameter in the HAV group,the average values of LPO in plasma and in erythrocytes,and NO in plasma in the AOPP group were significantly increased(P=0.00001),while the average values of VC,VE,β-CAR in plasma as well as SOD,CAT,GSH-PX and AChE in erythrocytes in the AOPP group were significantly decreased(P=0.000001).The finding of Pearoson product-moment correlation analysis between the value of AChE in erythrocytes and the values of above biochemical parameters for 58 AOPP patients showed that there was a significant linear negative correlation between AChE in erythrocytes and LPO,NO in plasma,and LPO in erythrocytes(P=0.00001-0.001319),while there was a significant linear positve correlation between AChE in erythrocytes and VC,VE,β-CAR in plasma as well as SOD,CAT,GSH-Px in erythrocytes(P=0.000013-0.000824),The results of discriminant analysis of above chemical parameters for 58 AOPP patients and 58 HAV suggested that the correct rates of discriminant analysis were increased to 100 3.395193e-313n the values of AChE and LPO in plasma and in erythrocytes,or AChE and others,were jointly used for the discriminant analysis ,Conclusion:The findings of the present study suggest that a series of free radical reactions in AOPP patients’ bodies are pathologically aggravat

关键词： organophosphorus pesticide poisoning Free radicals Lipoperoxides Nitric oxide Antioxidants Antioxidases

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Serum amylase as a novel prognostic marker of organophosphorus poisoning:a retrospective study

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Emergency and Critical Care Medicine 2024年第3期4卷 111-116页

作者： Xinxin Guo Zhongwei Chen Ke Feng Siyao Zeng Junfei Zhang Zhe Ma Changda Yuan School of Clinical Medicine Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Emergency Department General Hospital of Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina

Background:This study aims to explore the significance of serum amylase levels in patients with organophosphorus pesticide(OP)poisoning and to provide a new perspective for evaluating the severity and prognosis of OP ***:The clinical data of 67 patients with acute OP poisoning,who had been treated in the emergency department of the General Hospital of Ningxia Medical University between September 2020 and August 2022,were retrospectively *** Spearman rank correlation,serum amylase levels during admission and severity of poisoning correlated with discharge *** on serum amylase levels,receiver operating characteristic curves were plotted to predict the severity and mortality of patients who experience organophosphate *** optimal threshold serum amylase level at admission was determined based on the maximum Youden ***:Using Spearman rank correlation analysis,serum amylase levels at admission positively correlated with the severity of poisoning and discharge outcomes,but the degree of correlation was weak(r_(s):0.344;0.264;Ppoisoning and death,*** on the maximum Youden index,the optimal threshold of serum amylase were 97.8 and 194.1 U/L when the degree of poisoning was severe and the discharge outcome of patients was *** comparison to patients with serum amylase levels≤194.1 U/L at admission,the OR values of death in patients with serum amylase levels>194.1 U/L at admission was 15.944(95%CI:1.825-139.274).Conclusion:Serum amylase levels in patients with organophosphate poisoning correlate with the degree of poisoning and discharge *** serum amylase level was a risk factor for organophosphorus poisoning death.

关键词： Amylase Emergency department organophosphorus pesticide poisoning Prognosis

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