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Aggregate 2023年第6期4卷 153-162页

作者： Yunduo Charles Zhao Yingqi Zhang Arian Nasser Tianbo Hong Zihao Wang Allan Sun Laura Moldovan Leon S Edwards Freda Passam Ken S Butcher Timothy Ang Lining Arnold Ju School of Biomedical Engineering University of SydneyDarlingtonNew South WalesAustralia Charles Perkins Centre University of SydneyCamperdownNew South WalesAustralia The University of Sydney Nano Institute(Sydney Nano) University of SydneyCamperdownNew South WalesAustralia Heart Research Institute CamperdownNew South WalesAustralia Department of Neurosciences Gosford HospitalNorth GosfordNew South WalesAustralia Sydney Brain Centre Ingham Institute for Applied Medical ResearchLiverpoolNew South WalesAustralia South Western Sydney Clinical School University of New South WalesLiverpoolNew South WalesAustralia Department of Haematology Royal Prince Alfred HospitalCamperdownNew South WalesAustralia Central Clinical School Faculty of Medicine and HealthUniversity of SydneyCamperdownNew South WalesAustralia Prince of Wales Clinical School Prince of Wales HospitalRandwickNew South WalesAustralia Departments of Interventional Neuroradiology Neurology Royal Prince Alfred HospitalCamperdownNew South WalesAustralia

Cerebral venous sinus thrombosis(CVST)is a type of stroke associated with COVID-19 vaccine-induced immune thrombotic *** precise etiology of CVST often remains elusive due to the highly heterogeneous nature of its governing mechanisms,specifically,Virchow’s triad that involves altered blood flow,endothelial dysfunction,and hypercoagulability,which varies substantially amongst *** diagnostic and monitoring approaches lack the capability to reflect the combination of these patient-specific thrombotic *** response to this challenge,we introduce a Vein-chip platform that recapitulates the CVST vascular anatomy from magnetic resonance venography and the associated hemodynamic flow profile using the“Chinese Movable Type-like”soft stereolithography *** resultant full-lumen personalized Vein-chips,functionalized with endothelial cells,enable in-vitro thrombosis assays that can elucidate distinct thrombogenic scenarios between normal vascular conditions and those of endothelial *** former displayed minimal platelet aggregation and negligible fibrin deposition,while the latter presented significant fibrin extrusion from platelet *** low-cost movable typing technique further enhances the potential for commercialization and broader utilization of personalized Vein-chips in surgical labs and at-home *** research and development in this direction will pave the way for improved management and prevention of CVST,ultimately benefiting both patients and healthcare systems.

关键词： 3D printing cerebral venous sinus thrombosis mechanobiology organ on chip platelet Virchow’s triad

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