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Testicular exosomes disturb the immunosuppressive phenotype of testicular macrophages mediated by miR-155-5p in uropathogenic Escherichia coli-induced orchitis

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Asian Journal of Andrology 2023年第3期25卷 389-397页

作者： Jia Xu Chao He Yi-Wei Fang Zhi-Yong Hu Mei-Lin Peng Yuan-Yao Chen Yu-Fang Su Chun-Yan Liu Hui-Ping Zhang Kai Zhao Institute of Reproductive Health Center for Reproductive MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Male reproductive infections are known to shape the immunological homeostasis of the testes,leading to male ***,the specific pathogenesis of these changes remains poorly *** released in the inflammatory microenvironment are important in communication between the local microenvironment and recipient ***,we aim to identify the immunomodulatory properties of inflammatory testes-derived exosomes(IT-exos)and explore their underlying mechanisms in ***-exos were isolated using a uropathogenic Escherichia coli(UPEC)-induced orchitis model and confirmed that IT-exos promoted proinflammatory M1 activation with increasing expression of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6)in *** further used small RNA sequencing to identify the differential miRNA profiles in exosomes and primary testicular macrophages(TMs)from normal and UPEC-infected testes,respectively,and identified that miR-155-5p was highly enriched in IT-exos and TMs from inflammatory *** study of bone marrow derived macrophages(BMDMs)transfected with miR-155-5p mimic showed that macrophages polarized to proinflammatory *** addition,the mice that were administrated IT-exos showed remarkable activation of TM1-like macrophages;however,IT-exos with silencing miR-155-5p showed a decrease in proinflammatory ***,we demonstrate that miR-155-5p delivered by IT-exos plays an important role in the activation of TM1 in UPEC-induced *** study provides a new perspective on the immunological mechanisms underlying inflammation-related male infertility.

关键词： male infertility miR-155-5p orchitis testicular exosome testicular macrophage polarization

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Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord

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Asian Journal of Andrology 2020年第1期22卷 112-117页

作者： Diego Moreno Cristian M Sobarzo Livia Lustig Marcelo G Rodriguez Pena Vanesa Anabella Guazzone National Scientific and Technical Research Council-University of Buenos Aires Institute of Biomedical Research(INBIOMEDUBA-CONICET)Buenos Aires C 1121ABGArgentina Central Militar Hospital"Cirujano Mayor Dr.Cosme Argerich" Buenos Aires C 1426BORArgentina University of Buenos Aires School of MedicineDepartment of Cellular Biology and Histology/Academic Unit IIBuenos Aires C 1121ABGArgentina Militar Hospital"Campo de Mayo" Buenos Aires 1659Argentina

The aim of this work was to study effects of ketotifen fumarate(KF)on prevention of tissue damage in testes of rats with experimental autoimmune orchitis(EAO)and on the contralateral testis in a model of prolonged testicular cord torsion(TCT).Rats with EAO or TCT were injected intraperitoneally once daily with KF or saline solution(vehicle group).Incidence and severity of testicular damage were evaluated by histopathology using an EAO score or a Johnsen *** cells(MC)were identified by histochemistry and *** EAO model,KF significantly reduced severity of histopathological testicular damage compared to rats in the vehicle *** also reduced the number of testicular MC compared to vehicle ***,in TCT model,multifocal damage of the contralateral testis was observed 30 days after testicular torsion characterized by sloughing of the germinal epithelium,seminiferous tubule atrophy,and interstitial *** signs of inflammation and fibrosis of seminiferous tubular walls were also *** contrast,sections of contralateral testis of rats injected with KF and killed 30 days after surgery showed normal histological features.A significant decrease in the number of MC was observed in rats treated with KF compared to untreated *** conclusion,we demonstrated that treatment with KF reduced testicular inflammatory process and MC infiltrates in both EAO and TCT *** results suggest a promising treatment for infertile male patients with testicular pathologies associated with inflammation and germ cell loss.

关键词： ketotifen fumarate male infertility mast cells orchitis testicular cord torsion testis

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Isolated Autoimmune orchitis Due to IgG4 Hypersecretion Presenting as Tumor-Like Mass: Case Report and Review of Literature

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Open Journal of Urology 2022年第1期12卷 51-56页

作者： Francisco Marcos da Silva Barroso Flavio Antunes de Sousa Paloma Menezes de Souza Gustavo Lopes de Castro Katia Ramos Moreira Leite Monique Freire Santana Roger Arthur da Cunha Alves Gabriela Ayumi Owada Borges Juan Eduardo Rios Rodriguez Urology Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil General Surgery Service Santa Casa de Ribeir&#227 o Preto Ribeir&#227 o Preto Brazil Sã o Paulo University (USP) Ribeir&#227 o Preto Brazil Faculty of Medicine Federal University of Amazonas (UFAM) Manaus Amazonas Brazil Pathology Department Sírio-Libanes Hospital S&#227 o Paulo Brazil Faculty of Medicine S&#227 o Paulo University (USP) S&#227 o Paulo Brazil Patholgy Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil Dr. Heitor Vieira Dourado Tropical Medicine Foundation Manaus Amazonas Brazil Teaching and Research Department Oncology Center Control Foundation (FCECON) Manaus Amazonas Brazil Urology Service Hospital Pronto-Socorro 28 de Agosto Manaus Amazonas Brazil General Surgery Service Getúlio Vargas University Hospital (HUGV) Manaus Amazonas Brazil

Background: IgG4-related disease is a rare autoimmune condition that presents with lymphoplasmacytic infiltrate and fibrosis in the organ affected. Isolated testicle involvement is uncommon and there are only a few cases reported in the literature. Case Presentation: We report a case of isolated chronic orchitis due to IgG4 hypersecretion in a 61-year-old patient that evolved with asymptomatic tumor-like mass growth and was treated with left orchiectomy. Histopathological study revealed orchitis related to IgG4 hypersecretion disease. Conclusion: IgG4-related disease can be manifested as a multi or single-organ disorder. Most diagnoses are made after surgery with histopathological analysis. Most of the cases in literature stand out the difficulty in diagnosis and necessity of high suspicion due to this condition’s similarity with neoplasm presentation.

关键词： orchitis IgG4-Related Disease Autoimmune Testicle Inflammatory

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Serum Hormone and Cellular Proliferation Changes of Testis in Rats with Experimental orchitis Induced by Lipopolysaccharide

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Journal of Reproduction and Contraception 2007年第3期18卷 181-186页

作者： Li-ying XUE Xiang-hong ZHANG Ling-xiao XING Jie LI Geng-xin WANG Hebei Medical University Shijiazhuang 050011 China Hebei Provincial People＇s Hospital Shijiazhuang 050051 China

Objective To explore the changes of serum male hormone, androgen binding protein （ABP） expression as well as the proliferation of testicular cells in rats with experimental orchitis induced by bacterial lipoplysaccharide （LPS） in vivo and to elucidate the putative mechanism of LPS on spermatogenesis of testis. Methods The serum testosterone （T）, luteinizing hormone （LH） levels were detected with magnetic enzyme immunoassay. The expression of proliferating cell nuclear antigen （PCNA） and ABP expression at mRNA level of testis were studied with immunohistochemical staining and in situ hybrydization respectively. Results The serum T level in rats with experimental orchitis was significantly higher than that in the rats of control （P〈0.05） and ABP mRNA expression in Sertoli cells of testis was significantly increased （P〈0.05） while PCNA expression in seminiferous epithelium in experimental rats significantly was decreased as compared with that of the control （P〈0.05）. No significant change in serum LH level was seen between experimental orchitis and control groups （P〉0. 05）. Conclusion The serum level of T and ABP expression significantly increased in rats with experimental aspecific orchitis induced by LPS, and at the same time inhibition of cellular proliferation of seminiferous epithelium can be detected, which may be the possible mechanism of male infertility in inflammatory process.

关键词： orchitis LPS PCNA ABP testosterone

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Treatment of 18 orchitis Cases by Wrist- ankle Acupuncture

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Journal of Acupuncture and Tuina Science 2003年第1期1卷 32-33页

作者： BAI Shu-xiang HUANG Guo-qi Henan Community Health Service Station Xinzhan Town Jiaohe City Jilin 132506 China

Needle embedding at the first region of ankle acupuncture plus fomentation was used to treat 18 orchitis cases. The curative rate was 100%.

关键词： Acupuncture Therapy Ankle Acupuncture orchitis

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Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility

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Zoological Research 2023年第3期44卷 505-521页

作者： Meng-Fei Zhang Shi-Cheng Wan Wen-Bo Chen Dong-Hui Yang Wen-Qing Liu Ba-Lun Li Aili Aierken Xiao-Min Du Yun-Xiang Li Wen-Ping Wu Xin-Chun Yang Yu-Dong Wei Na Li Sha Peng Xue-Ling Li Guang-Peng Li Jin-Lian Hua College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Center of Reproductive Medicine Amsterdam Research Institute Reproduction and DevelopmentAcademic Medical CenterUniversity of Amsterdam 1105AZAmsterdamNetherlands Key Laboratory for Mammalian Reproductive Biology and Biotechnology Ministry of EducationInner Mongolia UniversityHohhotInner Mongolia 010021China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China

Bacterial or viral infections,such as Brucella,mumps virus,herpes simplex virus,and Zika virus,destroy immune homeostasis of the testes,leading to spermatogenesis disorder and *** note,recent research shows that SARS-CoV-2 can infect male gonads and destroy Sertoli and Leydig cells,leading to male reproductive *** to the many side effects associated with antibiotic therapy,finding alternative treatments for inflammatory injury remains ***,we found that Dmrt1 plays an important role in regulating testicular immune *** of Dmrt1 in male mice inhibited spermatogenesis with a broad inflammatory response in seminiferous tubules and led to the loss of spermatogenic epithelial *** immunoprecipitation sequencing(ChIP-seq)and RNA sequencing(RNA-seq)revealed that Dmrt1 positively regulated the expression of Spry1,an inhibitory protein of the receptor tyrosine kinase(RTK)signaling ***,immunoprecipitation-mass spectrometry(IP-MS)and co-immunoprecipitation(Co-IP)analysis indicated that SPRY1 binds to nuclear factor kappa B1(NF-κB1)to prevent nuclear translocation of p65,inhibit activation of NF-κB signaling,prevent excessive inflammatory reaction in the testis,and protect the integrity of the blood-testis *** view of this newly identified Dmrt1-Spry1-NF-κB axis mechanism in the regulation of testicular immune homeostasis,our study opens new avenues for the prevention and treatment of male reproductive diseases in humans and livestock.

关键词： Dmrt1 Spermatogenesis orchitis Spry1 NF-κB

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A scoping review of SARS-CoV-2 and male infertility: Concerns and future prospects

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Asian pacific Journal of Reproduction 2022年第2期11卷 53-61页

作者： Falah Hasan Obayes AL-Khikani Aalae Salman Ayit Medical Technique Department College of Medical TechniqueThe Islamic UniversityBabylonIraq

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been detected in the blood,urine,facial/anal swabs,semen,and vaginal discharge;all have been shown to contain SARSCoV-2 *** findings have highlighted the prospect of SARS-CoV-2 invading the genital system in addition to other tissues,which might give rise to reproductive *** investigation sheds light on male reproductive tract vulnerability to invasion by SARS-CoV-2 and provides a foundation for further researches into male *** are infected with COVID-19 at a higher rate than *** a result,some data suggest that this viral infection might affect the male reproductive *** probable causes for male genital tract abnormalities in COVID19 are:(1)high expression of angiotensin-converting enzyme 2 in the testes;(2)SARS-CoV-2 infection indirectly induces immune response in the testes;(3)SARS-CoV-2 directly damages male genital cells by virus-receptor binding activity;(4)fever in SARSCoV-2 infected males may cause damages to testicular cells;(5)testosterone level decreased in SAR-CoV-2 infected males;(6)males are more susceptible to COVID-19 than females,which may be due to differences in the physiology of the genital *** review seeks to offer some insights into the potential causes of COVID-19 that affect the male reproductive system,as well as future prospect on this issue.

关键词： Infertility COVID-19 SARS-CoV-2 Male reproductive system Coronavirus Genital tract abnormalities orchitis

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Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis

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Asian Pacific Journal of Tropical Biomedicine 2012年第4期2卷 311-314页

作者： Esmail Abolghasemi Seyed Hassan Moosa-Kazemi Maryam Davoudi Ahmad Reisi Mohammad Taghi Satvat Department of Medical Entomology and Vector Control School of Public HealthTehran University of Medical Sciences Department of Biostatistics and Epidemiology School of Public HealthTehran University of Medical Sciences Department of Parasitology and Mycology School of Public Health and Institute of Health ResearchesTehran University of Medical Sciences

Objective:To evaluate the effects of quinine and chloroquine against mole mice infected with Plasmodium berghei and their adverse effects on the mice ***:In this study,48 adult male mice,(20-23 g).aged 8 to 12 weeks were divided into four *** study was carried out from December 2009 until May 2010 in the School of Public Health,Tehran University of Medical ***:The results showed that 58.33%of mice treated with chloroquine were completely *** was 4%on day 8 when compared to that on day 0,whereas it was 9%on day *** was no orchitis found in this *** mortality of mice after exposing to quinine on day 5 was 8.3%,whereas from day 10 to day 14 it was 91.7%.We found 73%orchitis occurred in quinine treated *** was a significant difference between quinine and chloroquine effects on the parasite and also mice testes(P<0.05).Conclusions:In this study,It can be concluded that male mice have full resistance to the *** does not only make male mice recover completely,but also cause inflammation on mice testicles tissue.

关键词： Quinine Chloroquine orchitis Plasmodium berghei

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Infectious Pathology of the Scrotum in Abidjan: Ultrasound Features of 80 Cases

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Open Journal of Radiology 2017年第2期7卷 103-111页

作者： N’goran Kouame Fotso Sorel Manewa Amlan Marie-France Kouame Anne-Marie N’goan-Domoua Roger-Daniel N’gbesso Department of Radiology Yopougon University Hospital Abidjan Cote d’Ivoire

Objectives: The aim of this study was to determine the epidemiological-clinical profile of patients with scrotal infectious pathology in Abidjan and describe the ultrasound features of this scrotal infectious pathology. Methods: This was a prospective study of 80 cases of scrotal infectious pathology objectified by ultrasound at Yopougon University Hospital from 1 January 2015 to 31 December 2015. Ultrasounds were performed using a high-frequency linear probe in B and Color Doppler modes by senior radiologists. The epidemiological-clinical data were recorded from the ultrasound request form and the interrogation of the patient. Results: The average age was 23 years with extreme ranging from 16 to 40 years. Soldiers were the most concerned (40%) followed by students (30%). The painful large bursa was the quasi constant presenting feature (95% of cases) and fever was associated in less than half of the cases (45% of cases). The scrotal involvement was most often unilateral (85% of cases) and the left side was involved in 70% of the cases. Epididymitis was the most frequent pathology (60%) followed by orchiepididymitis (30%) and orchitis (10%). The most commonly encountered accompanying ultrasound findings were envelope thickening (100%), intravaginal fluid effusion (60%), and Doppler Hypervascularization (30%). Conclusion: In Abidjan Scrotal infectious pathology is most often encountered among young soldiers or students most often with a ± febrile large bursa. The most common pathology is left unilateral epididymitis.

关键词： orchitis Epididymitis Large Bursa Male Genital Infection

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Coccidioidomycosis of the Testis and Epididymis

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Open Journal of Urology 2013年第2期3卷 87-89页

作者： Dane E. Klett Y. Mark Hong Department of Urology Creighton University School of Medicine at St. Joseph’s Hospital & Medical Center Phoenix USA

This report describes an unusual presentation of a man with a testicular mass who presented in diabetic ketoacidosis to the emergency department. Initial diagnosis was a suspected testicular malignancy based on history, physical exam, and available laboratory and radiological imaging. Due to the possibility of a testicular malignancy, the patient was taken for immediate orchiectomy. Histology revealed coccidioido-mycosis of the left testicle and epididymis. Treatment with the appropriate antifungals was initiated. Despite aggressive multi-disciplinary therapy the patient continued to deteriorate and eventually expired as a result of the massive systemic infection. Literature review revealed the presentation of disseminated genitourinary coccidioidomycosis is rare and seldom reported.

关键词： Coccidioidomycosis Testicular Mass Epididymitis orchitis Valley Fever

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