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Treatment of Alzheimer’s disease by microcapsule regulates neurotransmitter release via microfluidic technology

Engineered Regeneration 2023年第2期4卷 183-192页

作者： Weina Yao Junyi Che Cheng Zhao Xiao Zhang Huijuan Zhou Feng Bai Department of Neurology Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210008China Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Gastroenterology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210096China Department of Neurology and The State Key Laboratory of Pharmaceutical BiotechnologyInstitute of Brain ScienceNanjing Drum Tower Hospital of The Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China Geriatric Medicine Center Affiliated Taikang Xianlin Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210008China

Alzheimer’s disease(AD)is a progressive neurodegenerative disease with a complex *** main neu-ropathological feature is the accumulation of amyloid-beta(Aβ),and the dysregulation of the cholinergic system is well associated with its mechanism of occurrence,for which no effective treatment is yet *** oral administration remains the mainstay of treatment with AD,and how to improve the efficacy,prolong adsorp-tion and medication compliance is still the focus of the current *** proposed a microcapsule based on microfluidic electrospray to form an intestinal epithelial lining for AD treatment,reducing the frequency of *** electrospray technology was recruited to overcome the limitations associated with the variability in the microencapsulation production process and to produce functional microcapsules with finely adapted chemical composition,capsule thickness and encapsulant volume *** microcapsules could slowly release drugs after adhering to the intestine,and their effectiveness and safety were further evaluated using cell culture studies and animal model *** results from the in vivo and in vitro experiments showed a significant reduction in administration frequency(i.e.,from daily medication to once every five days),superior therapeutic efficacy and sufficient safety of these microcapsules in cell culture and APP/PS1 *** features make the microcapsules an excellent drug delivery system and represent great potential for clinical applications in AD.

关键词： Microfluidics electrospray technologies oral microcapsules Alzheimer’s disease Treatment Administration frequency

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