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Cryomicroneedle delivery of nanogold-engineered Rhodospirillum rubrum for photochemical transformation and tumor optical biotherapy

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Bioactive Materials 2024年第7期37卷 505-516页

作者： Qingxia Shi Ting Yin Cuiping Zeng Hong Pan Ze Chen Lin Wang Bo Wang Mingbin Zheng Lintao Cai Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen518055China Guangdong Key Laboratory for Research and Development of Natural Drugs Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan523808China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen518055China National Clinical Research Center for Infectious Disease Shenzhen Third People’s HospitalThe Second Affiliated HospitalSouthern University of Science and TechnologyShenzhen518112China Sino-Euro Center of Biomedicine and Health Shenzhen518024China

Tumor metabolite regulation is intricately linked to cancer *** lactate is a characteristic metabolite of the tumor microenvironment(TME),it supports tumor progression and drives *** this study,we presented a strategy for antitumor therapy by developing a nanogold-engineered Rhodospirillum rubrum(R.r-Au)that consumed lactate and produced hydrogen for optical *** leveraged a cryogenic micromolding approach to construct a transdermal therapeutic cryomicroneedles(CryoMNs)patch integrated with R.r-Au to efficiently deliver living bacterial *** long-term storage studies revealed that the viability of R.r-Au in CryoMNs remained above 90%.We found that the CryoMNs patch was mechanically strong and could be inserted into mouse *** addition,it rapidly dissolved after administering bacterial drugs and did not produce *** laser irradiation,R.r-Au effectively enhanced electron transfer through Au NPs actuation into the photosynthetic system of *** and enlarged lactate consumption and hydrogen production,thus leading to an improved tumor immune *** study demonstrated the potential of CryoMNs-R.r-Au patch as a minimally invasive in situ delivery approach for living bacterial *** research opens up new avenues for nanoengineering bacteria to transform tumor metabolites into effective substances for tumor optical biotherapy.

关键词： Cryomicroneedles Photosynthetic bacteria Lactate depletion Hydrogen generation optical biotherapy

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