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A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex

Neuroscience Bulletin 2018年第6期34卷 1047-1057页

作者： Lingchi Xu Yalan Wan Longyu Ma Jie Zheng Bingxuan Han Feng-Yu Liu Ming Yi You Wan Neuroscience Research Institute Peking University Department of Clinical Medicine Zhongshan School of Medicine Sun Yat-Sen University Department of Neurobiology School of Basic Medical Sciences Peking University Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning Commission Peking University Co-innovation Center of Neuroregeneration Nantong University

Cognition and pain share common neural substrates and interact reciprocally: chronic pain compromises cognitive performance, whereas cognitive processes modulate pain perception. In the present study, we established a non-drug-dependent rat model of context-based analgesia,where two different contexts(dark and bright) were matched with a high(52°C) or low(48°C) temperature in the hot-plate test during training. Before and after training,we set the temperature to the high level in both contexts.Rats showed longer paw licking latencies in trials with the context originally matched to a low temperature than those to a high temperature, indicating successful establishment of a context-based analgesic effect in rats. This effect was blocked by intraperitoneal injection of naloxone(an opioid receptor antagonist) before the probe. The context-based analgesic effect also disappeared after optogenetic activation or inhibition of the bilateral infralimbic or prelimbic sub-region of the prefrontal cortex. In brief, we established a context-based, non-drug dependent, placebo-like analgesia model in the rat. This model provides a new and useful tool for investigating the cognitive modulation of pain.

关键词： Context-based analgesia Placebo analgesia Pain Hot-plate test Cognition modulation opioid system Prefrontal cortex

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