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Lamb’s tripe extract and vitamin B12 capsule plus celecoxib reverses intestinal metaplasia and atrophy:A retrospective cohort study

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World Journal of Clinical Cases 2021年第34期9卷 10472-10483页

作者： Si-Ran Wu Jie Liu Li-Feng Zhang Na Wang Lu-Yao Zhang Qiong Wu Jun-Ye Liu Yong-Quan Shi State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive DiseasesXijing HospitalAir Force Military Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Clinical Nutrition Xijing HospitalAir Force Military Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Radiation Protective Medicine Air Force Military Medical UniversityXi'an 710032Shaanxi ProvinceChina

BACKGROUND Chronic atrophic gastritis(AG)with intestinal metaplasia(IM)significantly increases the risk of gastric *** medicines have showed definite therapeutic effects in AG and IM *** To validate the efficacy of Lamb’s tripe extract and vitamin B12 capsule(LTEVB12)initial therapy and celecoxib rescue therapy for IM and *** A total of 255 patients were included to receive LTEVB12 initial therapy(2 capsules each time,three times daily for 6 mo)in hospital in this *** patients with failure of IM regression continued to receive celecoxib rescue therapy(200 mg,once daily for 6 mo).After each therapy finished,the patients underwent endoscopy and biopsy *** regression efficiency was assessed by the operative link on gastritis assessment(OLGA)and the operative link on the gastric intestinal metaplasia assessment(OLGIM)staging *** regression analysis was applied to identify factors associated with the curative *** For LTEVB12 initial therapy,the reversal rates of IM and AG were 52.95%and 48.24%,***,for celecoxib rescue therapy,the effective rates for IM and AG were 56.25%and 51.56%,*** IM regression rate of complete therapy was up to 85.03%.In different OLGA and OLGIM stages of IM patients,therapeutic efficiency showed a significant difference in each group(P<0.05).For both therapies,patients with high stages(III or IV)of both the OLGA and OLGIM evaluation systems showed a higher IM or AG regression rate than those with low stages(I or II).Among patients with high stages(OLGIM III and IV),the IM regression rate was above 70%for each *** habits,fresh vegetable intake,and high-salt diet were identified as independent factors for the IM reversal effect of LTEVB12 therapy,especially high-salt diet(odds ratio=1.852,P<0.05).CONCLUSION Monotherapy could reverse IM and ***12 initial therapy and celecoxib rescue therapy significantly increase the regression effect.I

关键词： Atrophy gastritis Intestinal metaplasia Celecoxib Stomach neoplasms operative link on the gastric intestinal metaplasia assessment operative link on the gastritis assessment

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