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woLiver Regeneration Effect of oncostatin M Following Hepatectomy for the Rat Cirrhotic Liver Model

Surgical Science 2012年第11期3卷 530-536页

作者： Naoki Togo Masaki Ueno Kazuhisa Uchiyama Satoru Ozawa Hiroki Yamaue Second Department of Surgery School of Medicine Wakayama Medical University Wakayama Japan

Background/Aims: Liver resection represents the treatment of choice for hepatocellular carcinoma (HCC) arising in well-compensated cirrhosis. Gene expression of the multifunctional cytokine, oncostatin M (OSM), stimulates liver regeneration and adenoviral vector expressing OSM (AdOSM) allows a persistent expression of the gene. The aim of this study is to evaluate the benefits of the preoperative injection of AdOSM to the remnant lobes to regenerate the liver. Methods: A 70% partial hepatectomy was performed in dimethylnitrosamine-administrated cirrhotic rats with a preoperative injection of AdOSM, adenoviral vector carrying β-galactosidase (AdLacZ), or phosphate-buffered saline (PBS). The morphologic, histologic, and biochemical changes in the remnant liver and survival rates were then assessed. Results: Portal injection with clamping the portal branches of the resected lobes for 5 min made it possible to effectively transduce the adenoviral vector into the remnant lobes. The ratio of the remnant liver weight/body weight (%) was 2.3 ± 0.5 in the AdOSM group, 1.1 ± 0.3 in the AdLacZ group (p < 0.001), and 1.6 ± 0.4 in the PBS group (p = 0.02). The fibrous ratio (%) was 21.3 ± 4.6 in the AdOSM group and 35.2 ± 4.5 in the AdLacZ group on day 4 after hepatectomy and fibrous status was significantly decreased in the AdOSM group (p = 0.02). Serum hyaluronic acid which is the indicator of liver fibrosis was 215 ± 141 ng/mL in the AdOSM group and 1963 ± 1225 ng/mL in the AdLacZ group (p = 0.03). Conclusions: The OSM gene therapy may increase the possibility of hepatectomy in a cirrhotic liver by improving fibrosis, hepatic function, and hepatocyte regeneration.

关键词： oncostatin M Liver Regeneration Cirrhosis Anti-Fibrosis

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Cardiomyocyte proliferation and dedifferentiation mediated by OSM in heart regeneration

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中国循环杂志 2018年第S1期33卷 127-127页

作者： Yandong Li Yu Nie Shengshou Hu State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular DiseasesFuwai HospitalCAMS and PUMCBeijingChina

Background Neonatal mouse heart can completely regenerate after amputating 15%of ventricular ***,the regenerative ability is lost by 7 *** dedifferentiation is the only way of existing myocytes returning to cell cycle and initiating *** M(OSM)was demonstrated to promote cardiomyocyte dedifferentiation after cardiac injury,while its role in heart regeneration has not been *** the progress of dedifferentiationproliferation through OSM may provide a clinical therapy for preventing further deterioration of patients with heart injury and restoring the lost myocardium.

关键词： Neonatal mouse heart ventricular apex oncostatin M(OSM)

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