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MicroRNA-188-5p targeting Forkhead Box L1 promotes colorectal cancer progression via activating Wnt/β-catenin signaling

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Oncology Research 2021年第2期29卷 119-128页

作者： JIALIN WU ZEHONG CHEN WENWEI LIU YONGXIN ZHANG WEI FENG YUJIE YUAN JINNING YE LIANG WANG SHIRONG CAI YULONG HE SUIJING WU WU SONG Center of Gastrointestinal Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Hepatobiliary and Pancreatic Surgery Union Shenzhen HospitalHuazhong University of Science and TechnologyShenzhenChina Department of Gastrointestinal Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Guangdong General HospitalGuangzhouChina

Objective:MicroRNA-188-5p(miR-188)enhances oncologic progression in various human *** study aimed to explore its role in colorectal cancer(CRC).Materials and Methods:Human CRC tissues paired with normal tissues,and several CRC cell lines were ***-time quantitative PCR was applied to measure the expression of *** and knockdown were used to access the function of miR-188 and to investigate whether FOXL1/Wnt signaling mediates such *** proliferation,migration and invasion of cancer cells were evaluated by CCK8,wound-healing and transwell assays,*** FOXL1 acted as a direct target of miR-188 was verified by dual-luciferase reporter ***:Levels of miR-188 were upregulated in CRC tissues than in paired-normal tissues,as well as in various CRC cell *** expression of miR-188 was strongly associated with advanced tumor stage,accompanied with significant tumor cell proliferation,invasion and *** was confirmed that FOXL1 played positive crosstalk between miR-188 regulation and downstream Wnt/β-catenin signaling ***:All findings indicate that miR-188 promotes CRC cell proliferation and invasion through targeting FOXL1/Wnt signaling and could be served as a potential therapeutic target for human CRC in the future.

关键词： miR-188 Colorectal adenocarcinoma Oncogenesis oncologic progression Wnt signaling

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