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Risk of hepatitis B virus reactivation in oncological patients treated with tyrosine kinase inhibitors:A case report and literature analysis

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World Journal of Gastroenterology 2024年第9期30卷 1253-1256页

作者： Francesca Colapietro Nicola Pugliese Antonio Voza Alessio Aghemo Stella De Nicola Department of Biomedical Sciences Humanitas UniversityMilan 20072Italy Division of Internal Medicine and Hepatology Department of GastroenterologyHumanitas Research HospitalMilan 20089Italy Department of Emergency Humanitas Research HospitalMilan 20089Italy

Hepatitis B virus(HBV)reactivation(HBVr)represents a severe and potentially life-threatening condition,and preventive measures are available through blood test screening or prophylactic therapy *** assessment of HBVr traditionally considers factors such as HBV profile,including hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core antigen,along with type of medication(chemotherapy;immunomodulants).Nevertheless,consideration of possible patient’s underlying tumor and the specific malignancy type(solid or hematologic)plays a crucial role and needs to be assessed for decision-making process.

关键词： Chronic hepatitis B Reactivation Nucleoside analogue Tyrosine kinase inhibitors onco-hematology

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Fever and Infection Prevalence in hematology-oncology Hospitalized Patients: A Single-Center Retrospective Study

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Journal of Cancer Therapy 2018年第3期9卷 231-241页

作者： Inês Almeida Costa Sérgio Chacim José Mariz Internal Medicine Department Centro Hospitalar de Sao Joao Porto Portugal Departmentof hematology-oncology Clinic Instituto Português de Oncologia (IPO) Porto Portugal

Fever is prevalent in hospitalized patients. In hematology-oncology patients, it is related with infection, a disease manifestation or a consequence of immunological dysfunction. This single-center retrospective study aims to determine fever prevalence, describe its causes and evaluate the impact of infection on mortality. We reviewed clinical records of 222 patients admitted to the hospital in three random months of 2015. Around 35% of all hospitalizations were complicated by fever, 42.5% of unknown origin. 90.4% were under treatment. Around 81% did antibiotics, most commonly piperacillin/tazobactam, for around 11 days. 41% changed antibiotics due to fever persistence or microbiological results. The diagnostic yield of microbiological tests was 25%;in 66.7%, a Gram-negative microorganism was isolated. We didn’t find an association between infection and mortality. We conclude that fever is common in our hematology-oncology clinic and that the team is trained to assume infection;empirical treatment is in accordance with international recommendations.

关键词： Fever Infection hematology-oncology onco-hematology Neutropenia

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Plasma Cell Leukemia: A Case Report and Literature Review

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Open Journal of Blood Diseases 2020年第3期10卷 71-76页

作者： B. Malam-Abdou A. Djibrilla Almoustapha M. Chefou S. Brah M. Maman Brah F. Abba Ousmane M. Daou M. A. Mahamane Sani M. R. Badé E. O. Adehossi onco-hematology Department of Niamey National Hospital Niamey Niger Department of Internal Medicine at the General Reference Hospital of Niamey Niamey Niger Department of Internal Medicine at Niamey National Hospital Niamey Niger

Plasma cell leukemia is a rare malignant hemopathy, characterized by a peripheral plasma cell proliferation of more than 20% of the leukocyte formula. A few rare cases have been described. From which we report a case of plasma cell leukemia in a 52-year-old Nigerien subject initially in a coma, whose anemia led to the diagnosis in the onco-hematology department of the National Hospital of Niamey and the evolution was marked by clinical and biological remission after 3 cures of CTD, but died in an infectious picture after 6 cures.

关键词： Plasma Cell Leukemia onco-hematology HNN Niamey-Niger

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