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Impact of five annual rounds of mass drug administration with ivermectin on onchocerciasis in Sierra Leone

Infectious Diseases of Poverty 2018年第1期7卷 314-325页

作者： Joseph B.Koroma Santigie Sesay Abdul Conteh Benjamin Koudou Jusufu Paye Mohamed Bah Mustapha Sonnie Mary H.Hodges Yaobi Zhang Moses J.Bockarie Family Health International(FHI)360 Ghana Country OfficeAccraGhana National Neglected Tropical Disease Control Programme Ministry of Health and SanitationFreetownSierra Leone Centre for Neglected Tropical Diseases Liverpool School of Tropical MedicineLiverpoolUK Helen Keller International FreetownSierra Leone Helen Keller International Regional Office for AfricaDakarSenegal European&Developing Countries Clinical Trials Partnership(EDCTP) Medical Research CouncilCape TownSouth Africa

Background:onchocerciasis is endemic in 12 of the 14 health districts of Sierra *** treatment coverage of community-directed treatment with ivermectin was achieved between 2005 and 2009 after the 11-year civil *** site surveys were conducted in 2010 to evaluate the impact of five annual rounds of ivermectin ***:In total,39 sentinel villages from hyper-and meso-endemic areas across the 12 endemic districts were surveyed using skin snips in *** were analyzed and compared with the baseline data from the same 39 ***:The average microfilaridermia(MF)prevalence across 39 sentinel villages was 53.10%at *** MF prevalence was higher in older age groups,with the lowest in the age group of 1-9 years(11.00%)and the highest in the age group of 40-49 years(82.31%).Overall mean MF density among the positives was 28.87 microfilariae(mf)/snip,increasing with age with the lowest in the age group of 1-9 years and the highest in the age group of 40-49 *** had higher MF prevalence and density than *** 2010 after five rounds of mass drug administration,the overall MF prevalence decreased by 60.26%from 53.10%to 21.10%;the overall mean MF density among the positives decreased by 71.29%from 28.87 mf/snip to 8.29 mf/snip;and the overall mean MF density among all persons examined decreased by 88.58%from 15.33 mf/snip to 1.75 mf/*** of 12 endemic districts had>50%reduction in MF *** of 12 districts had≥50%reduction in mean MF density among the ***:A significant reduction of onchocerciasis MF prevalence and mean density was recorded in all 12 districts of Sierra Leone after five annual MDAs with effective treatment *** results suggested that the onchocerciasis elimination programme in Sierra Leone was on course to reach the objective of eliminating onchocerciasis in the country by the year *** MDA with ivermectin should continue in all 12 districts and furthe

关键词： onchocerciasis Onchocerca volvulus Mass drug administration Community-directed treatment with ivermectin Community-directed drug distributor Skin snip onchocerciasis-endemic Post-conflict Disease elimination Rapid diagnostic test

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