BackgroundIn onchocerciasis-endemic areas with high ongoing onchocerca volvulus transmission,a high prevalence of epilepsy has been *** study aimed to determine the prevalence and clinical characteristics of epilepsy ...
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BackgroundIn onchocerciasis-endemic areas with high ongoing onchocerca volvulus transmission,a high prevalence of epilepsy has been *** study aimed to determine the prevalence and clinical characteristics of epilepsy in the Bono Region of Ghana following 27 years of implementation of ivermectin mass drug administration(MDA).MethodsBetween October 2020 and August 2021,cross-sectional surveys were conducted in nine communities in the Tain District and Wenchi Municipality of the Bono Region of *** the first stage,a random door-to-door approach was used to screen the population for epilepsy using a pre-tested *** suspected of having epilepsy were invited for a second-stage neurological examination for case *** *** microfilarial infection status and Ov16 seropositivity were also ***-five confidence intervals(95%CI)for prevalence values were calculated using the Wilson Score *** the 971 participants,500(51.5%)were females,and the median age(interquartile range)was 26(15‒43)*** participants(1.4%,95%CI:1.0‒2.0)were diagnosed as having epilepsy with generalized seizures being the most frequent seizure type(85.7%,12/14).The overall microfilarial prevalence of *** was 10.3%(November 2020)and 9.9%(August 2021);the Ov16 seroprevalence was 22.2%(June 2021).Only 63.2%took ivermectin in the last round of MDA distribution in March *** 1.4%prevalence of epilepsy in the Bono region is similar to the median epilepsy prevalence in sub-Saharan ***,the persistent microfilarial prevalence and low ivermectin study coverage call for the Ghana Onchocerciasis Elimination Programme to step up its efforts to ensure that the gains achieved are consolidated and improved to achieve the elimination of onchocerciasis by 2030.
Background:Onchocerciasis is endemic in 12 of the 14 health districts of Sierra *** treatment coverage of community-directed treatment with ivermectin was achieved between 2005 and 2009 after the 11-year civil *** sit...
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Background:Onchocerciasis is endemic in 12 of the 14 health districts of Sierra *** treatment coverage of community-directed treatment with ivermectin was achieved between 2005 and 2009 after the 11-year civil *** site surveys were conducted in 2010 to evaluate the impact of five annual rounds of ivermectin ***:In total,39 sentinel villages from hyper-and meso-endemic areas across the 12 endemic districts were surveyed using skin snips in *** were analyzed and compared with the baseline data from the same 39 ***:The average microfilaridermia(MF)prevalence across 39 sentinel villages was 53.10%at *** MF prevalence was higher in older age groups,with the lowest in the age group of 1-9 years(11.00%)and the highest in the age group of 40-49 years(82.31%).Overall mean MF density among the positives was 28.87 microfilariae(mf)/snip,increasing with age with the lowest in the age group of 1-9 years and the highest in the age group of 40-49 *** had higher MF prevalence and density than *** 2010 after five rounds of mass drug administration,the overall MF prevalence decreased by 60.26%from 53.10%to 21.10%;the overall mean MF density among the positives decreased by 71.29%from 28.87 mf/snip to 8.29 mf/snip;and the overall mean MF density among all persons examined decreased by 88.58%from 15.33 mf/snip to 1.75 mf/*** of 12 endemic districts had>50%reduction in MF *** of 12 districts had≥50%reduction in mean MF density among the ***:A significant reduction of onchocerciasis MF prevalence and mean density was recorded in all 12 districts of Sierra Leone after five annual MDAs with effective treatment *** results suggested that the onchocerciasis elimination programme in Sierra Leone was on course to reach the objective of eliminating onchocerciasis in the country by the year *** MDA with ivermectin should continue in all 12 districts and furthe
The aims of this investigation were to isolate active ingredients from the roots/rhizomes of Cyperus articulatus used as herbal medicine in Cameroon for the treatment of human onchocerciasis and to assess the efficacy...
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The aims of this investigation were to isolate active ingredients from the roots/rhizomes of Cyperus articulatus used as herbal medicine in Cameroon for the treatment of human onchocerciasis and to assess the efficacy of the metabolites on the onchocerca *** antifilarial activity was evaluated in vitro on microfilariae(Mfs)and adult worms of the bovine derived onchocerca ochengi,a close relative of onchocerca *** was assessed in vitro on monkey kidney epithelial *** structures of the active compounds were determined using spectroscopic methods and their drug-likeness evaluated using Lipinski *** secondary metabolites,AMJ1[containing mustakone(1)as the major component]and linoleic acid or(9Z,12Z)-octadeca-9,12-dienoic acid(2)were *** compounds were found to kill both the microfilariae and adult worms of *** in a dose dependent *** IC50s for AMJ1 were 15.7 lg/mL for Mfs,17.4 lg/mL for adult males and 21.9 lg/mL for adult female worms while for linoleic acid the values were,15.7 lg/mL for Mfs,31.0 lg/mL for adult males and 44.2 lg/mL for adult *** present report provides the first ever evidence of the anti-onchocerca efficacy of AMJ1 and linoleic ***,these secondary metabolites may provide a lead for design and development of new antifilarial agents.
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