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Neural Regeneration Research 2011年第11期6卷 860-864页

作者： Wei Yi Lin Liu Okechi Humphrey Qianxue Chen Shulan Huang Department of Neurosurgery Renmin Hospital of Wuhan University Wuhan 430060 Hubei Province China Department of Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

The current study investigated correlations between the expression of leucine-rich repeats and immunoglobulin-like domain 1 （LRIG1） and antioxidant enzymes and related proteins, including manganese superoxide dismutase, glutamate cysteine ligase catalytic or regulatory subunit, thioredoxin and thioredoxin reductase, in both human ependymoma and oligodendroglioma. Results revealed that the cytoplasmic expression of LRIG1 was associated with expression of glutamate cysteine ligase catalytic subunit in the human ependymoma, while the nuclear expression of LRIG1 was associated with expression of thioredoxin reductase. In human oligodendroglioma, the cytoplasmic expression of LRIG1 was associated with expression of the glutamate cysteine ligase catalytic subunit. Both the nuclear and perinuclear expressions of LRIG1 were associated with expression of glutamate cysteine ligase regulatory subunit. These results indicated that several antioxidant enzymes and related proteins contributed to LRIG1 expression, and that these may participate in the antioxidation of the cells.

关键词： leucine-rich repeats and immunoglobulin-like domain 1 sub-cellular localization ependymoma oligodendroglioma antioxidant enzymes

Primary spinal cord oligodendroglioma:a case report and review of the literature

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Chinese Neurosurgical Journal 2016年第1期2卷 -页

作者： Thara Tunthanathip Thakul Oearsakul Neurosurgical Unit Department of Surgery Faculty of Medicine Prince of Songkla University Hat Yai Songkhla 90110 Thailand

Primary spinal cord oligodendroglioma is extremely rare. In an extensive review of this disease, 53 cases were reported. Furthermore, the authors summarize the characteristics of the primary spinal cord oligodendroglioma; chronological presentation , neurological imaging, treatment and the outcome obtained in the present case as well as review the literature. A 46-year-old male who had progressive neck pain for a year. Magnetic resonance imaging showed an intramedullary mass from level C2 to T4. A radical resection was performed. Histology revealed oligodendroglioma. Thereafter, the patient was treated with adjuvant radiotherapy. A year later, tumor developed recurrence. The patinet died in 3 years and 6 months. The available data of this disease was limited. Base on 11 published papers and the present case, surgical resection is the treatment of choice although recurrence of the tumor tends to occur after partial resection with or without radiotherapy. From the literature, the management of the recurrent disease is still surgery. Moreover, Temozolomide may be an advantage in recurrent situations.

关键词： oligodendroglioma Spinal cord tumor Intramedullary tumor Treatment

Radical Resection of Adult Low Grade oligodendroglioma without Adjuvant Therapy: Results of a Prospective Treatment Protocol—Surgical Treatment of Low-Grade oligodendroglioma

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Journal of Cancer Therapy 2011年第2期2卷 235-242页

作者： Donald A. Ross Lynda Yang Oren Sagher Amy M. Ross 不详

The goal of this work was to demonstrate prospectively that maximal surgical resection of low grade oligodendrogliomas without adjuvant therapy does not reduce life expectancy over that of historical controls. All patients with surgically accessible grade II oligodendrogliomas underwent maximal resection using stereotactic guidance and/or cortical mapping and were followed with serial MRI scans without adjuvant therapy until either progression or spread into brain regions deemed not surgically resectable. Nineteen patients were treated between 1993 and 2006. Ten patients required reoperation an average of 55 months after their first surgery. Nine patients progressed to anaplastic tumors an average of 42 months after their first surgery: six patients died from their tumors an average of 73 months after diagnosis, two are still alive 76 and 18 months after progression, and one was lost to follow up. Ten patients are alive and progression-free an average of 116 months after diagnosis, one of whom was lost to follow up at 106 months from diagnosis. Four patients are alive and event-free an average of 125 months after diagnosis. All are male and three had tumors in the superior frontal gyrus. The event-free survival, progression-free survival, and overall survival of our patients are not worse than those of patients treated with postoperative adjuvant therapy. Withholding adjuvant therapy at diagnosis appears to be safe. It will be important to establish the molecular differences between the patients who did very well and those who progressed so that adjuvant therapy could be offered to the latter.

关键词： Corticography Craniotomy Extent Of Resection oligodendroglioma

Surgical strategy in case with co-existence of malignant oligodendroglioma and arteriovenous malformation: A case report

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Case Reports in Clinical Medicine 2013年第8期2卷 473-478页

作者： Hirohito Yano Noriyuki Nakayama Naoyuki Ohe Toshinori Takagi Jun Shinoda Toru Iwama Chubu Medical Center for Prolonged Traumatic Brain Dysfunction Department of Neurosurgery Kizawa Memorial Hospital Minokamo Japan Department of Neurosurgery Gifu University Graduate School of Medicine Gifu Japan Department of Neurosurgery Gifu University Graduate School of Medicine Gifu Japan

A brain tumor associated with an arteriovenous malformation (AVM) is very rare. A 42-year-old female presented with two separate lesions in her right frontal lobe on MRI. An angiogram diagnosed one of the lesions as an AVM. The second lesion appeared to be a tumor. Tumor removal was difficult due to bleeding from the nearby AVM, necessitating removal of the AVM and allowing complete excision of the tumor. Histopathological analysis revealed the tumor was an anaplastic oligodendroglioma. There was no recurrence of the tumor 5 year after completion of therapy. We discuss the operative strategy in case of synchronous diseases and provide a review of the literature.

关键词： oligodendroglioma Arteriovenous Malformation Co-Existence

Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domains is related to antioxidant enzymes in human ependymoma and oligodendroglioma

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Expression and sub-cellular localization of leucine-rich rep...

oligodendroglioma: CD44 as a possible prognostic opportunity

2011中华医学会神经外科学学术会议

作者： Wei Yi1 Lin Liu1 Qianxue Chen1 Shulan Huang1 1.Renmin Hospital of Wuhan University

The current study investigated correlations between the expression of leucine-rich repeats and immunoglobulin-like domain 1 (LRIG1) and antioxidant enzymes and related proteins, including manganese superoxide dismutas... 详细信息

关键词： leucine-rich repeats and immunoglobulin-like domain 1 sub-cellular localization ependymoma oligodendroglioma antioxidant enzymes neural regeneration

来源： cnki会议评论

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中国神经肿瘤杂志 2003年第3期1卷 143-143页

作者： Buccoliero AM Caldarella A Arganini L Mennonna P Ammanati F Taddei A Taddei GL Dipartimento di Patologia Umana e Oncologia Universita degli Studi di FirenzeItaly

CD44, in its standard form as well in its isoforms, is a cell surface adhesion glycoprotein which occurs in a widevariety of non-neoplastic and neoplastic ceils. CD44 has been considered to be implicated in tumoral growth andin metastatic potential. We studied the immunohistochemical expression of CD44 standard in 30 oligodendrogliomas(19 primary lesions and 11 recurrences) in order to verify its possible prognostic role. Twelve primary oligoden-

关键词： CD44 as a possible prognostic opportunity oligodendroglioma were

Updates on management of gliomas in the molecular age

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World Journal of Clinical Oncology 2024年第2期15卷 178-194页

作者： Ali Ahmed Mohamed Rakan Alshaibi Steven Faragalla Youssef Mohamed Brandon Lucke-Wold Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Florida International UniversityMiamiFL 33199United States College of Osteopathic Medicine Kansas City UniversityJoplinMO 64804United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic *** developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular *** review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year *** adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and *** contrast,pediatric gliomas,due to their diversity,require a more tailored *** complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and ***-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be *** recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric *** review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.

关键词： Gliomas Chemotherapy Radiotherapy Isocitrate dehydrogenase type mutant Pediatric gliomas Astrocytoma oligodendroglioma 1p/19q-codeleted

Chromosome 1p/19q status combined with expression of protein improves the diagnostic and prognostic evaluation of oligodendrogliomas

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Chinese Medical Journal 2010年第24期123卷 3566-3573页

作者： XIONG Ji LIU Ying WANG Yin KE Rong-hu MAO Ying YE Zhu-rong Department of Neuropathology Institute of Neurology Huashan Hospital of Fudan University Shanghai 200040 China Department of Pathology Shanghai Medical College of Fudan University Shanghai 200032 China Department of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 China

Background Our previous study confirmed that oligodendrogliomas had higher frequency of chromosome 1p/19q deletion. In order to improve the diagnostic criteria and to predict the prognosis of oligodendroglioma patients, the status of chromosome 1 p/19q deletion, the methylation of O6-methylguanine-DNA methyltransferase （MGMT）, and the expression of p53 protein were evaluated and investigated in relation to patients＇ *** Methylation of MGMT in 73 cases was analyzed by nested methylation-specific PCR （MSP）. The levels of MGMT and p53 protein were tested with immunohistochemistry. Pearson＇s chi-square test and Fisher＇s exact test were used. Multivariate and Kaplan-Meier analysis were performed to determine patients＇ *** Both oligodendrogliomas and astrocytic gliomas exhibited frequent methylation of MGMT. However, the results of MSP did not completely correspond to that of the immunohistochemical staining for MGMT. The expression of p53 protein was more frequently observed in patients without a 1 p or 19q deletion in anaplastic oligodendrogliomas （=0.032,0.025）. In low-grade oligodendrogliomas, methylation of MGMT was more frequent in patients with 1 p/19q deletion than in patients with 1p/19q intact （P=0.038）. Patients with oligodendrogliomas with 1p/19q loss of heterozygosity and p53-negative showed a longer progression-free *** Detection of chromosome 1p/19q status combined with p53 protein immunohistochemistry might be beneficial to improve the pathological diagnosis and to determine the prognosis of patients with oligodendrogliomas.

关键词： astrocytic glioma O6-methylguanine-DNA methyltransferase oligodendroglioma p53 protein 1p/19q deletion

Clinico-neuropathological features of isocitrate dehydrogenase 2 gene mutations in lower-grade gliomas

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Chinese Medical Journal 2019年第24期132卷 2920-2926页

作者： Lei-Ming Wang Zhuo Li Yue-Shan Piao Yan-Ning Cai Li-Yan Zhang Hai-Jing Ge Wei-Wei Xu De-Hong Lu Department of Pathology Xuanwu HospitalCapital Medical UniversityKey Laboratory for Neurodegenerative DiseasesMinistry of EducationBeijing 100053China Department of Neurobiology Xuanwu HospitalCapital Medical UniversityKey Laboratory for Neurodegenerative DiseasesMinistry of EducationBeijing 100053China National Clinical Research Centre for Geriatric Disorders Beijing 100053China

Background:Mutations in the isocitrate dehydrogenase 1(IDH1)and IDH2 genes are important for both the integrated diagnosis and the prognosis of diffuse *** p.R132H mutation of IDH1 is the most frequently observed IDH mutation,while IDH2 mutations were relatively rarely *** aim of the study was to determine the pathological and genetic characteristics of lowergrade gliomas that carry IDH2 ***:Data from 238 adult patients with lower-grade gliomas were retrospectively *** status of IDH1/2 gene mutations,telomerase reverse transcriptase(TERT)promoter mutations,O^6-methylguanine-DNA-methyltransferase(MGMT)promoter methylation,1p/19q co-deletion and the expressions of IDH1 R132H,alpha-thalassemia X-linked mental retardation,and p53 were ***-free survival(PFS)and overall survival(OS)were calculated via Kaplan-Meier estimation using the log-rank ***:Totally,71%(169/238)of patients were positive for IDH mutations,including 12 patients harboring mutations in *** the 12 patients with IDH2 mutations,ten patients harbored the R172K mutation,one patient harbored the R172S mutation and one harbored the R172W *** these,11 tumors occurred in the frontal lobe and showed morphology typical of *** proportion of grade II tumors was higher than that of grade III tumors in IDH2 ***2 mutations were frequently associated with TERT promoter mutations,1p/19q co-deletion and MGMT promoter ***2 mutations were associated with better outcomes compared with IDH wild-type gliomas(Poligodendrogliomas and associated with a better ***2 mutations may segregate in distinct clinico-pathological and genetic subtypes of gliomas,and therefore may merit routine investigation.

关键词： Isocitrate dehydrogenase 1 Isocitrate dehydrogenase 2 Telomerase reverse transcriptase Glioma oligodendroglioma

Stromal and Tumor Glioma-derived Cells with Similar Characteristics Have Differences in α-Smooth Muscle Actin Expression and Localization

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Journal of Oncology Research 2021年第2期3卷 8-21页

作者： I.Gin I.Chistyakova V.Zenin S.Koshkin A.Musorina Y.Lahina G.Timin V.Pospelov S.Prikhodko A.Petukhov E.Tolkunova Institute of Cytology Russian Academy of SciencesSt.Petersburg194064Russia Almazov National Medical Research Centre St.Petersburg197341Russia Peter the Great Saint-Petersburg Polytechnic University St.Petersburg195251Russia Scientific Technological University«Sirius» Sochi354340Russia

Gliomas are solid brain tumors composed of tumor cells and recruited heterogenic stromal *** study of the interactions between the perivascular niche and its surrounding cells is of great value in unraveling mechanisms of drug resistance in malignant *** this study,we isolated the stromal diploid cell population from oligodendroglioma and a mixed population of tumor aneuploid and stromal diploid cells from astrocytoma *** stromal cells expressed neural stem/progenitor and mesenchymal markers showing the same discordant phenotype that is typical for glioma ***,some of the stromal cells expressed *** the first time,we demonstrated that this type of stromal cells had the typical myofibroblastic phenotype as theα-SMA+cells formedα-SMA fibers and exhibited the specific function to deposit extracellular matrix(ECM)proteins at least in *** analysis showed diffuse or focalα-SMA staining in the cytoplasm of the astrocytoma-derived,A172,T98G,and U251MG glioma *** could suggest thatα-SMA may be one of the main molecules,bearing protective *** mechanisms and consequences ofα-SMA disruptions in gliomas are discussed.

关键词： oligodendroglioma Astrocytoma Primary cell cultures Tumor microenvironment Myofibroblasts Extracellular matrix