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ofloxacin的抗支原菌活性

齐鲁药事 1984年第3期 48-48页

作者：焦建宇山东省医药工业研究所

Ofloxacia代号DL-8280,化学名称:DL—9—氟—2,3—二氢—3—甲基—10—(4—甲基—1—哌嗪基)—7—氧—7氢—吡啶并[1,2,3—de3[1,4]氧氮杂萘—6—羧酸。化学结构: 本品是一个新的喹啉衍生物,同吡哌酸、norfloxacin(AM715)相比,它具有... 详细信息

Ofloxacia代号DL-8280,化学名称:DL—9—氟—2,3—二氢—3—甲基—10—(4—甲基—1—哌嗪基)—7—氧—7氢—吡啶并[1,2,3—de3[1,4]氧氮杂萘—6—羧酸。化学结构: 本品是一个新的喹啉衍生物,同吡哌酸、norfloxacin(AM715)相比,它具有抗菌谱广和作用更强的抗菌活性,不但对兼性厌氧菌,而且对专性厌氧菌,其活性均超过吡哌酸和AM715。在治疗支原菌的感染方面,吡哌酸、

关键词：抗菌活性专性厌氧菌吡哌酸兼性厌氧菌 ofloxacin 哌嗪基氮杂萘化学结构 ofloxacin 抗菌剂

ofloxacin—一种喹诺酮羧酸与其它喹诺酮类化合物及其它抗生素的体外活性比较

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中国临床药理学杂志 1986年第2期 137-137页

作者：关立农

ofloxacin,代号DL—8280,是一种新的喹诺酮羧酸化合物。为研究其抗菌活性,本文进行了如下工作:抗菌敏感实验,包括最低抑菌浓度实验(MIC)及最低杀菌浓度实验(MBC);耐药菌的筛选;杀菌曲线实验;小白鼠保护实验;与其它抗生素的协同

关键词：抑菌浓度克雷小白鼠大肠杆菌大肠埃希氏菌埃希氏杆菌属抗生素 ofloxacin 青霉素抗菌素肠杆菌属肠杆菌科抗菌活性

新抗菌药ofloxacin对肺结核的疗效观察

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国外医学.呼吸系统分册 1986年第2期 99-99页

作者：李国利

作者报道新抗茵药ofloxacin(DL8280)对肺结核病人进行实验性治疗。选例标准:19例病人都是慢性空洞性肺结核,并还在排对各种抗结核药物抗药的结核菌。口服DLB280,每日早饭后一次,剂量为300mg,连服6或8个月。每月做痰标本检查,用金胺染色... 详细信息

作者报道新抗茵药ofloxacin(DL8280)对肺结核病人进行实验性治疗。选例标准:19例病人都是慢性空洞性肺结核,并还在排对各种抗结核药物抗药的结核菌。口服DLB280,每日早饭后一次,剂量为300mg,连服6或8个月。每月做痰标本检查,用金胺染色显微镜检查痰菌,在吐温鸡蛋培养基上培养。测定DL8280的血浆浓度并进行胸部X线照片,以便综合判定疗效。结果表明,该药对治疗肺结核病人是有效的。3

关键词：肺结核病人 ofloxacin 痰菌抗菌药

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ND-011氟嗪酸(ofloxacin)

中国医药工业杂志 1986年第10期 45-45页

作者：郭惠元

9-氟-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧-2,3-二氢-7H-吡啶并[1,2,3-de][1,4]苯并噁嗪-6-羧酸

关键词： ND-011 ofloxacin

Study on the susceptibility genes that mediate the resistance of Helicobacter pylori to clarithromycin and levofloxacin based on comprehensive antibiotic research database comparison

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China Medical Abstracts(Internal Medicine) 2022年第2期39卷 109-110页

作者： LU Tao Dept Gastroenterol&Hepatol Univ Hong Kong-Shenzhen HospShenzhen 518053

Objective To explore the new genes related to the resistance of H. pylori to clarithromycin (CLA) and levofloxacin (LVX) based on whole-genome *** From September 1st, 2016 to August 31st,2019, 1 749 patients with upper gastrointestinal symptoms and positive13C urea breath test who visited the Department of Gastroenterology and Hepatology, the University of Hong Kong-Shenzhen Hospital were enrolled.

关键词： pylori ofloxacin Helicobacter

哌拉西林与氧氟沙星联合抗菌活性的研究(摘要)

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中国医院药学杂志 1993年第7期13卷 17-18,49页

作者：王睿孙效东刘卫谢平田桂荣张有江中国人民解放军总医院北京100853

目前对于严重的难治性感染性疾病常采用抗菌药物联合治疗。本文根据棋盘法设计,应用微量稀释法研究了酰脲类青霉素哌拉西林(Piperacillin,PIP)与氟喹诺酮类药物氧氟沙星(ofloxacin,OFLX)的体外联合抗菌活性。

关键词： combined antibacterial activity piperacillin ofloxacin FIG index

Management of end-stage renal failure:a Hong Kong perspective

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Chinese Medical Journal 1997年第6期110卷 33-39页

作者： ChanTak-Mao Division of Nephrology Department of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong

Ｍａｎａｇｅｍｅｎｔｏｆｅｎｄｓｔａｇｅｒｅｎａｌｆａｉｌｕｒｅ：ａＨｏｎｇＫｏｎｇｐｅｒｓｐｅｃｔｉｖｅＣｈａｎＴａｋＭａｏＲｅｎａｌｒｅｐｌａｃｅｍｅｎｔｔｈｅｒａｐｉｅｓｆｏｒｐａｔｉｅｎｔｓｗｉｔｈｅｎｄ... 详细信息

Ｍａｎａｇｅｍｅｎｔｏｆｅｎｄｓｔａｇｅｒｅｎａｌｆａｉｌｕｒｅ：ａＨｏｎｇＫｏｎｇｐｅｒｓｐｅｃｔｉｖｅＣｈａｎＴａｋＭａｏＲｅｎａｌｒｅｐｌａｃｅｍｅｎｔｔｈｅｒａｐｉｅｓｆｏｒｐａｔｉｅｎｔｓｗｉｔｈｅｎｄｓｔａｇｅｒｅｎａｌｆａｉｌｕｒ...

关键词： AMBULATORY PERITONEAL-DIALYSIS C VIRUS-INFECTION RECOMBINANT-HUMAN-ERYTHROPOIETIN CHRONIC HEPATITIS-C CLINICOPATHOLOGICAL FEATURES TRANSPLANT RECIPIENTS HEMODIALYSIS-PATIENTS ofloxacin MORTALITY TWICE

Fly ash and zero-valent iron-based in situ advanced anaerobic digestion with emphasis on the removal of antibiotics and antibiotic resistance genes from sewage sludge

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Waste Disposal and Sustainable Energy 2022年第1期4卷 17-28页

作者： Minquan Zhang Yadan Wangjin Haidong Zhou Ziming Zhao Zhengcao Cao Zhenxi Ying School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Technical Institute of Electronics Information ShanghaiChina

This study investigated the removal of antibiotics and antibiotic resistance genes from sewage sludge by using fly ash(FA)-based in situ advanced anaerobic digestion(AAD)under mesophilic *** antibiotics(sulfadiazine,sulfameth-oxazole,ofloxacin,tetracycline,and roxithromycin)and 11 corresponding antibiotic resistance genes(Ib-cr,qnrS,ermF,ermT,ermX,sul1,sul2,sul3,tetA,tetB,and tetG)were selected as the *** FA to anaerobic digestion to remove antibiotics and resistance genes allows waste to be treated with ***-based in situ AAD of sewage sludge effectively enhanced the process stability and methane yield,and the optimal FA-added dosage was 50 mg/*** cumulative methane yield could be well described with the improved Gompertz *** addition effectively increased the overall removal of ofloxacin,by up to 85.3%at 50 mg/L FA and 10μg/L antibiotics,and the combination of zero-valent iron and FA enhanced only the overall removal of ofloxacin to 92.4%and tetracycline to 85.6%.However,FA-based in situ AAD could not enhance the overall removal of other antibiotics from sewage *** all the same types of antibiotic resistance genes were strongly positively correlated with the concentrations of *** removal of antibiotic resistance genes influenced by FA addition varied largely with the types of antibiotic resistance genes,FA dosage,antibiotic content,and the combination with zero-valent *** addition could not be verified to enhance the removal of antibiotic resistance *** addition of FA or zero-valent iron and the antibiotic concentrations significantly changed the microbial community structure during in situ AAD,and the combination of zero-valent iron and FA significantly reduces the species diversity and microbial *** most abundant bacteria were Methanogarcina,Methanoberium,unidentified_Archaea,Terrimonas,Methomethoxychlo-rovorans,and Candidatus_Cloacimonas in the ZVI-FA test.

关键词： Biogas production Methane yield ofloxacin Relative abundance Microbial community structure

Second and third line treatment options for Helicobacter pylori eradication

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World Journal of Gastroenterology 2014年第6期20卷 1517-1528页

作者： Mingjun Song Tiing Leong Ang Department of Gastroenterology Changi General Hospital

Helicobacter pylori is a highly successful bacterium with a high global prevalence and the infection carries significant disease burden. It is also becoming increasingly difficult to eradicate and the main reason for this is growing primary antibiotic resistance rates in a world where antibiotics are frequently prescribed and readily available. Despite knowing much more about the bacterium since its discovery, such as its genomic makeup and pathogenesis, we have seen declining treatment success. Therefore, clinicians today must be prepared to face one, two or even multiple treatment failures, and should be equipped with sufficient knowledge to decide on the appropriate salvage therapy when this happens. This article discusses the factors contributing to treatment failure and reviews the second and thirdline treatment strategies that have been investigated. Established empiric second line treatment options include both bismuth based quadruple therapy and levofloxacin based triple therapy. Antibiotic testing is recommended prior to initiating third line treatment. In the event that antibiotic susceptibility testing is unavailable, third line treatment options include rifabutin, rifaximin and sitafloxacin based therapies.

关键词： Helicobacter pylori Treatment failure Salvage therapy Drug resistance Microbial Bismuth ofloxacin Moxifloxacin Metronidazole Rifabutin Rifaximin Sitafloxacin