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Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis:A case report

World Journal of Clinical Cases 2022年第19期10卷 6536-6542页

作者： Peter Kiraly Alenka Lavrič Groznik Nataša Vidovič Valentinčič Polona Jaki Mekjavić Mojca Urbančič Janja Ocvirk Tanja Mesti Eye Hospital University Medical Centre LjubljanaGrablovičeva 46SI-1000 LjubljanaSlovenia Oxford Eye Hospital Oxford University Hospitals NHS Foundation TrustOX39DUOxfordUnited Kingdom Department of Medical Oncology Institute of Oncology LjubljanaFaculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia

BACKGROUND Immune checkpoint inhibitors have revolutionized the treatment of patients with unresectable metastatic malignant *** addition to systemic side effects,several usually mild ocular adverse effects have been *** report a case of rarely reported vision-threatening bilateral panuveitis with serous retinal detachment,thickened choroid,and chorioretinal folds associated with dabrafenib and trametinib targeted therapy for B-Raf proto-oncogene serine/threonine kinase(BRAF)mutant metastatic cutaneous *** SUMMARY A 59-year-old female patient with metastatic melanoma treated with dabrafenib and trametinib presented with blurry vision and central scotoma lasting for 3 d in both *** examination and multimodal imaging revealed inflammatory cells in the anterior chamber,mild vitritis,bullous multiple serous retinal detachments,and chorioretinal folds in both *** with dabrafenib and trametinib was suspended,and the patient was treated with topical and intravenous corticosteroids followed by oral corticosteroid treatment with a tapering *** and a half months after the disease onset,ocular morphological and functional improvement was *** to the metastatic melanoma dissemination,BRAF/mitogen-activated protein kinase inhibitors were reintroduced and some mild ocular adverse effects reappeared,which later subsided after receiving oral *** Patients on combination therapy with dabrafenib and trametinib may rarely develop severe bilateral panuveitis with a good *** studies have to establish potential usefulness of ophthalmological examination for asymptomatic ***,appropriate guidelines for managing panuveitis associated with dabrafenib and trametinib should be established.

关键词： Metastatic melanoma treatment BRAF/MEK inhibitors Dabrafenib and trametinib ocular adverse effects Bilateral panuveitis Case report

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