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ocular surface microbiota in patients with varying degrees of dry eye severity

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 1986-1995页

作者： Xin-Rong Zou Pei Zhang Yuan Zhou Yao Yin Department of Ophthalmology Fengcheng HospitalFengxian DistrictShanghai 201411China Fengcheng Branch Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 201411China Department of Ophthalmology Huashan Hospital of Fudan UniversityShanghai 200040China Department of Ophthalmology Gonghui HospitalJing’an DistrictShanghai 200436China

AIM:To elucidate the profiles of commensal bacteria on the ocular surfaces of patients with varying severity of dry eye(DE).METHODS:The single-center,prospective,case-control,observational study categorized all participants into three distinct groups:1)control group(n=61),2)mild DE group(n=56),and 3)moderate-to-severe DE group(n=82).Schirmer’s tear secretion strips were used,and the bacterial microbiota was analyzed using 16S ribosomal ribonucleic acid gene ***:The three groups had significant differences in alpha diversity:the control group had the highest richness(Chao1,Faith’s phylogenetic diversity),the mild DE group showed the highest diversity(Shannon,Simpson),and the moderate-to-severe DE group had the lowest of the above-mentioned *** severity was positively correlated with a reduction in beta diversity of the microbial community,with the moderate-to-severe DE group exhibiting the lowest beta *** discriminant analysis effect size presented distinct dominant taxa that significantly differed between ***,the exacerbation of DE corresponded with the enrichment of certain pathogenic bacteria,as determined by random forest ***:As DE severity worsens,microbial community diversity tends to *** development corresponds with changes in microbial constituents,primarily characterized by reduced microbial diversity and a more homogenous species composition.

关键词： dry eye microbiota ocular surface tear film break up time

Impact of COVID-19 pandemic on the ocular surface

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World Journal of Clinical Cases 2022年第27期10卷 9619-9627页

作者： Ana Marta Joao Heitor Marques Daniel Almeida Diana José Paulo Sousa Irene Barbosa Department of Ophthalmology Centro Hospitalar Universitário do PortoPorto 4099-001Portugal

BACKGROUND There have been increased reports of dry eyes in the coronavirus disease 2019(COVID-19) pandemic *** To analyze the differences in tear film properties from pre-and post-pandemic of the COVID-19 *** It was a retrospective comparative *** were divided into three groups according to the data of multimodal ocular surface evaluation:(1) Group 1 if it was before Portugal lockdown decision(from August 2019 to March 2020);(2) Group 2 if it was after Portugal lockdown decision but without mask mandate(from April 2020 to October 2020);and(3) Group 3 if it was after Portugal lockdown but with mask mandate in health public highway(from November 2020 to April 2021).The following variables were analyzed:Lipid layer thickness,blink rate,Schirmer test,tear meniscus height,tear osmolarity,non-invasive break-up time,and loss area of the meibomian *** The study included 548 eyes of 274 patients,aged 18 years to 89 years,with a mean age of 66.15 ± 13.40 years at the time of multimodal ocular surface *** to group 1:(1) Mean lipid layer thickness was better in group 2(P = 0.001) and group 3(P < 0.001);(2) Schirmer test was similar in group 2(P = 0.576) and better in group 3(P = 0.002);(3) Tear osmolarity and loss area of the meibomian glands were worse in group 2(P = 0.031 and P < 0.001,respectively) and in group 3(both with P < 0.001);(4) Blink rate and tear meniscus height were similar in group 2(P = 0.821 and P = 0.370,respectively) and worse in group 3(P < 0.001 and P = 0.038,respectively);and(5) Non-invasive break-up time was worse in group 2(P = 0.030) and similar in group 3(P = 0.263).CONCLUSION Our study demonstrated that differences existed in tear film properties comparing data from the pre-and post-pandemic of the COVID-19 era.

关键词： ocular surface Dry eye Face masks Mask-associated dry eye COVID-19 pandemic

Effects of perioperative managements on ocular surface microbiota in intravitreal injection patients

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 248-254页

作者： Ya-Guang Hu Qiong Wu Tian-Hui Li Fang Sui Ming Zhang Zhen Zhang Rui Shi Na Hui Li Qin Li Li Department of Ophthalmology the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Ophthalmology Northwest Women and Children's HospitalXi'an 710061Shaanxi ProvinceChina Key Laboratory of Biomedical Information Engineering Ministry of EducationXi'an 710049Shaanxi ProvinceChina Department of Biomedical Engineering School of Life Science and TechnologyXi'an Jiaotong UniversityXi'an 710049Shaanxi ProvinceChina Department of Otorhinolaryngology-Head and Neck Surgery the First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Ophthalmology Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina Xi'an Huaxia Eye Hospital Xi'an 710061Shaanxi ProvinceChina

AIM:To investigate the effects of on ocular surface microbiota in patients who received intravitreal ***:Samples of ocular surface microbiota were obtained from 41 eyes of 41 patients who visited the Department of *** were separated for three *** A did not receive perioperative managements or intravitreal *** B1 received only once and B2 received more than *** operating room,the samples were collected on the ocular *** taxonomic units(OTUs) clustering and alpha/beta diversity analysis was *** microbial 16S rRNA from samples were analyzed using the Hi Seq 2500 ***:Alpha diversity did not differ in each group,and beta diversity differed in the B2 *** diversity showed a significant difference between Group A and B2(P=0.048).With the perioperative managements before intravitreal injection,the composition and relative abundance were *** 10 microbiota on phylum and genus level,and then microbiota notably changed at genus level were ***-negative bacteria were varied ***,Proteus was not found in Groups A and B1,but it was appeared after the patients received perioperative management and intravitreal injections in Group ***:With the perioperative managements,the balance of microbiota on the ocular surface is destroyed,and relative composition and abundance of microbiota on the ocular surface is obviously *** clinical doctors should pay more attention on the consequence of perioperative managements before intravitreal injection.

关键词： microbiota perioperative managements ocular surface intravitreal injection high-throughput sequencing

The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery:A meta-analysis for time of intervention

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Advances in Ophthalmology Practice and Research 2022年第3期2卷 1-7页

作者： Yuhang Zhang Ying Qi Xiaohang Xie Fengyan Zhang The Division of Ophthalmology and Vision Science Department of OphthalmologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina College of Medicine Zhengzhou UniversityZhengzhouChina

Purpose The effect of interventional time for 3% Diquafosol reatment in post-cataract surgery has not been well established.A meta-analysis was performed to evaluate the improvement of ocular surface condition in post-cataract surgery patients who received 3% DQS for various treatment *** Studies were performed based on 5 databases:PubMed,Cochrane Library,Web of Science,Embase,and China National Knowledge *** on changes in Schirmer’s test,tear breakup time(TBUT),corneal staining score,and OSDI score were collected for *** A total of 621 affected eyes from 9 independent clinical studies were included.6 studies conducted Schirmer's test after the application of 3% ***-analysis showed that the difference between 3% DQS and control groups was not statistically significant for short-term application(less than or equal to 1 month)(WMD=0.14,P=0.27,95% CI:-0.11 to 0.39),but was statistically different for long-term application(longer than or equal to 3 months)(WMD=0.76,P=0.03,95% CI:0.08 to 1.45).For the corneal fluorescence staining score,the data from 6 studies indicated that the improvement was statistically significant for short-term application(WMD=-0.40,Pocular surface ***-term application resulted in lower corneal staining scores,prolonged TBUT,and imp

关键词： Diquafosol Cataract surgery ocular surface Meta-analysis

ocular surface changes in type II diabetic patients with proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 358-364页

作者： Yan Gao Yan Zhang Yu-Sha Ru Xiao-Wu Wang Ji-Zhong Yang Chun-Hui Li Hong-Xing Wang Xiao-Rong Li Bing Li Shanxi Eye Hospital College of Optometry and Ophthalmology Tianjin Medical University Tianjin Medical University Eye Institute Tianjin Medical University Eye Hospital Department of Ophthalmology Shanxi Medical University First Hospital Department of Ophthalmology Beijing Chuiyangliu Hospital Affiliated to Tsinghua University

AIM: To detect and analyze the changes on ocular surface and tear function in type II diabetic patients with proliferative diabetic retinopathy(PDR), an advanced stage of diabetic retinopathy(DR), using conventional ophthalmic tests and the high-resolution laser scanning confocal ***: Fifty-eight patients with type II diabetes were selected. Based on the diagnostic criteria and stage classification of DR, the patients were divided into the non-DR(NDR) group and the PDR group. Thirty-six patients with cataract but no other ocular and systemic disease were included as non-diabetic controls. All the patients were subjected to the conventional clinical tests of corneal sensitivity, Schirmer I test, and corneal fluorescein staining. The non-invasive tear film break-up time(NIBUT) and tear interferometry were conducted by a Tearscope Plus. The morphology of corneal epithelia and nerve fibers was examined using the high-resolution confocal ***: The NDR group exhibited significantly declined corneal sensitivity and Schirmer I test value, as compared to the non-diabetic controls(P ocular surface changes, including blunted corneal sensitivity, reduced tear secretion, tear film dysfunction, progressive loss of corneal epithelia and degeneration of nerve fibers, are common in type II diabetic patients, particularly in the diabetic patients with PDR. The corneal sensitivity, fluorescein staining scores,and the density of corneal epithelial cells and nerve fibers in the diabetic patients correlate with

关键词： type II diabetes proliferative diabetic retinopathy ocular surface corneal sensitivity confocal microscopy tear film break-up time

ocular surface changes in Graves’ophthalmopathy

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 616-621页

作者： Rou Sun Hui-Fang Zhou Xian-Qun Fan Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and ocular Oncology Shanghai 200011China

Many patients with Graves’ophthalmopathy(GO)suffer from dry eye syndrome(DES),and this is one of the most common reasons of eye discomfort in patients with *** prevalence of DES in patients with GO is significantly higher than normal *** ocular surface changes involving changes in tears,cornea,conjunctiva and glands occur in GO ***,the mechanism of how DES occurs in GO still remains *** this review,the ocular surface changes were illustrated and analyzed the reasons for high prevalence of DES in GO patients.

关键词： Graves’ophthalmopathy dry eye syndrome ocular surface

Correlation of the retinopathy degree with the change of ocular surface and corneal nerve in patients with type 2 diabetes mellitus

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International Journal of Ophthalmology(English edition) 2021年第5期14卷 750-758页

作者： Jia-Xin Han He Wang Huan-Huan Liang Jian-Xin Guo Xuzhou Medical University Xuzhou 221002Jiangsu ProvinceChina Department of Ophthalmology Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

AIM:To investigate the change of ocular surface and corneal nerve and their correlation in patients suffering from type 2 diabetes mellitus under different degrees of ***:Totally 129 type 2 diabetes mellitus patients(257 eyes)were *** were divided into three groups:no diabetic retinopathy(NDR)group(33 cases,66 eyes),non-proliferative diabetic retinopathy(NPDR)group(32 cases,64 eyes),and proliferative diabetic retinopathy(PDR)group(34 cases,67 eyes).Healthy normal individuals were enrolled as controls(30 cases,60 eyes).ocular surface Disease Index(OSDI)questionnaire was completed by all subjects,and dry eye analyzer was applied to examine tear meniscus height(TMH),first tear break-up time(FTBUT),average tear break-up time(ATBUT),tear film lipid layer thickness classification,and meibomian gland loss(MGL)*** nerve fiber density(CNFD),corneal nerve branch density(CNBD),corneal nerve fiber length(CNFL),and corneal nerve fiber tortuosity(CNFT)were examined by in vivo confocal microscopy(IVCM).The differences and correlation among these parameters were ***:Total OSDI score,TMH,FTBUT,ATBUT,tear film lipid layer thickness,MGL score,CNFD,CNBD,CNFL,and CNFT were statistically different among the four groups(P<0.05).In NDR group,CNFL was positively correlated with TMH(r=0.493,both P<0.01)and ATBUT(r=0.437,P<0.05).CNFL in NPDR group was positively correlated with TMH(r=0.642,P<0.01)and ATBUT(r=0.6,P<0.01).CNFL in PDR group was positively correlated with TMH(r=0.364,P<0.05)and ATBUT(r=0.589,P<0.01),with low negative correlation with MGL score(r=-0.331,P<0.05).CONCLUSION:With the progression of diabetic retinopathy,TMH,BUT,lipid layer thickness,CNFL,CNFD,and CNBD gradually decreased,while total OSDI score,MGL score,and CNFT *** is correlated with TMH and ATBUT in diabetic patients.

关键词： type 2 diabetes retinopathy ocular surface corneal nerve in vivo confocal microscopy

SARS-CoV-2 in the ocular surface of COVID19 patients

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Eye and Vision 2020年第3期7卷 229-231页

作者： Hua-Tao Xie Shi-Yun Jiang Kang-Kang Xu Xin Liu Bing Xu Lin Wang Ming-Chang Zhang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Clinical Laboratory Research Center for Tissue Engineering and Regenerative MedicineUnion HospitalHuazhong University of Science and TechnologyWuhan 430022China

The 2019 novel coronavirus disease(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has spread globally,while the routes of transmission of this virus are still *** enrolled 33 patients,without any ocular manifestation,with their ocular surface swabs collected for virus *** was detected strong positive in samples of both eyes from two ***,SARS-CoV-2 may exist in the normal ocular surface of COVID-19 patients,suggesting that this virus might be spread through conjunctival contact.

关键词： SARS-CoV-2 COVID-19 ocular surface

Comparison of early changes in ocular surface markers and tear inflammatory mediators after femtosecond lenticule extraction and FS-LASIK

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 283-291页

作者： Chi Zhang Hui Ding Hong He He Jin Liang-Ping Liu Xiao-Wei Yang Jun Yang Xing-Wu Zhong Huaxia Eye Hospital of Foshan Huaxia Eye Hospital GroupFoshan 528000Guangdong ProvinceChina Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology Sun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Hainan Eye Hospital and Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityHaikou 570311Hainan ProvinceChina

AIM:To compare the short-term impacts of femtosecond lenticule extraction(FLEx)and femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK)on ocular surface measures and tear inflammatory ***:This prospective comparative nonrandomized clinical study comprised 75 eyes(75 patients).Totally 20 male and 15 female patients(age 21.62±3.25 y)with 35 eyes underwent FLEx,and 26 male and 14 female patients(age 20.18±3.59 y)with 40 eyes underwent *** corneal sensitivity,noninvasive tear breakup time,corneal fluorescein staining,Schirmer I test,tear meniscus height,and ocular surface disease index were evaluated in all *** concentrations of nerve growth factor(NGF),interleukin-1α(IL-1α),transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),and matrix metalloproteinase-9(MMP-9)were assessed by multiplex antibody *** measurements were performed preoperatively,and 1 d,1 wk,and 1 mo ***:Patients who underwent FLEx exhibited a more moderate reduction in central corneal sensation and less corneal fluorescein staining than those in the FS-LASIK group 1 wk after the procedure(Pocular surface changes after FLEx or FS-LASIK ***:There is less early ocular surface disruption and a reduced inflammatory response after FLEx than after ***,TGF-β1,TNF-α,and IL-1αmay contribute to the process of ocular surface recovery.

关键词： femtosecond lenticule extraction femtosecond laser-assisted laser in situ keratomileusis tear inflammatory mediators ocular surface