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Predictive value of CA-153,CA-125 and Apo A for ocular metastasis in menopausal female patients with breast cancer

International Journal of Ophthalmology(English edition) 2024年第12期17卷 2265-2275页

作者： Qun-Ce Liu Qian Ling Yan-Mei Zeng Cheng Chen Hong Wei Jin-Yu Hu Jie Zou Xiao-Yu Wang Xu Chen Yi Shao Department of Laboratory Medicine Guangxin District Maternal and Child Health HospitalShangrao 334000Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China

AIM:To establish a meaningful standard for diagnosing ocular metastasis(OM)in menopausal breast cancer(BC)women,and explore the relationship between CA-153,CA-125,apolipoprotein A,and ***:A total of 1362 menopausal female BC patients with OM volunteered to take part in this study between July 2012 and July *** with BC who are menopausal were found to have an OM incidence of 1.6%.Furthermore,CA-153,CA-125,and apolipoprotein A(Apo A)all contributed to OM in women with BC who are postmenopausal according to binary logistic *** operating curve(ROC)analysis was used to assess the diagnostic value of OM in patients with ***:Both CA-153 and CA-153+CA-125 showed a higher sensitivity of 95.45%,whereas CA-153+Apo A illustrated the highest specificity of 99.02%.Moreover,CA-153 and CA-153+CA-125 had higher areas under the curve(AUC)of ***:The data indicate that the serum concentrations of CA-153 exhibited the most significant predictors of the diagnosis of OM in menopausal women with *** current study researches the utility of risk factors in predicting of OM in menopausal BC women and put forward the latest suggestions on their clinical application.

关键词： menopausal female patients breast cancer ocular metastasis CA-125 CA-153 apolipoprotein A

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Esophageal Cancer metastasis to the Eye: A Case Report and Literature Review

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Open Journal of Thoracic Surgery 2021年第3期11卷 69-75页

作者： Ramzi A. Addas Ahmed M. Alsabban Abdullah A. Fallatah Aqeel S. Binaqeel Salman W. Bafageeh Department of Thoracic and General Surgery King Abdulaziz Medical City Jeddah KSA

ocular metastasis is an uncommon occurrence that usually has a poor prognosis. The most frequent causes of intraocular metastases as reported in the literature are breast and lung cancers. Intraocular metastasis originating from esophageal cancer is very rare. We discuss a case of 58 years old man known case of adenocarcinoma of the esophagogastric junction presenting with ocular metastasis in King Abdulaziz Medical City, Jeddah, Saudi Arabia. Clinical symptoms led to the investigations and diagnosis of the ocular metastasis which without these symptoms it would have been missed. We concluded that a careful and good review of the whole body is essential in the optimal diagnosis of metastatic lesions especially when it comes to a rare metastasis like ocular metastasis from esophageal cancer.

关键词： Esophageal Cancer ocular metastasis Orbital MRI Palliative Therapy

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Metastatic breast cancer:an unusual cause of diplopia

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Journal of Cancer metastasis and Treatment 2016年第1期2卷 123-126页

作者： Nasser Mohammed Amer Gareth Bashir Arikoge Ogedegbe Ibtisam Saeed Department of General Surgery University of DammamAl Khobar 40262Kingdom of Saudi Arabia Department of General Surgery King George HospitalIlford IG38YBUK Department of Pathology Queens HospialRomford RM70AGUK

While secondary solid cancer into the eye orbit is rare,it is the most common site for primary metastasis in female breast *** report a case of a sixty-six years old woman presenting to her optician with complaints of double *** resonance imaging revealed an invasive lesion in the superior and medial rectus muscles of the right orbit,biopsy of which confirmed this as an infiltrating breast *** of the primary lesion showed an advanced invasive ductal carcinoma of the right *** was then treated with radiotherapy to the orbit and a non steroidal aromatase inhibitor Anastrozol(Arimidex®).We herein review and discuss the literature,epidemiology,mechanism of tumor spread,the“seed and soil”theory,clinical presentation,pathology,and management of this uncommon presentation.

关键词： Metastatic breast cancer diplopia ocular metastasis

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