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Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei ZHANG Heng Dong ZHU Bao Li School of Public health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of occupational Disease Prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for Disease Prevention and Control Suzhou 215004JiangsuChina Center for Global health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological mechanisms.Methods Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by ELISA.Results Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 expression.Similarly, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 levels.Conclusion This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN occupational mercury exposure occupational health PI3K/AKT pathway 293T cell IL-6

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Sleep Disorders among Professional Oil Tanker Drivers in Ouagadougou Burkina Faso

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occupational Diseases and Environmental Medicine 2024年第1期12卷 1-20页

作者： Guy Alain Ouédraogo Dofinihanou Dite Inessa Coulibaly Mênonli Adjobimey Abdoul Risgou Ouédraogo Rose Mikponhoue Antoine Vikkey Hinson health Sciences Training and Research Unit University of Ouahigouya Ouagadougou Burkina Faso Department of Pneumology Regional University Hospital of Ouahigouya Ouagadougou Burkina Faso Workers health Office Ouagadougou Burkina Faso occupational and Environmental health Research Unit Faculty of Health Sciences Cotonou Republic of Benin health Sciences Training and Research Unit Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Introduction: Sleep disorders among professional drivers are a major road safety problem. They cause fatigue and drowsiness at the wheel, which can lead to road traffic accidents and even accidents at work. The aim of this study was to assess sleep disorders among professional drivers of oil tankers in Ouagadougou, Burkina Faso. Methods: This was a descriptive and analytical cross-sectional study carried out from 11 April 2020 to 11 September 2020 in the national hydrocarbon company’s fuel depot. All the drivers present at the time were included and accomplished a questionnaire incorporating the commonly scales using to assess sleep disorders, sleep quality and sleep apnoea. Data analysis using R 3.6.1 software enabled to perform univariate and multivariate analyses to identify associated factors. Adjusted odd ratios were used to measure the strength of association. The significance level chosen was p ≤ 0.05. Results: All the 339 respondents were male. A proportion of 33.6% suffered from insomnia, including 12.7% with moderate to severe insomnia, and 18.58% were at risk of sleep apnoea. On the Epworth scale, 26.6% of drivers showed sleep debt and 4.1% excessive daytime sleepiness. The risk factors associated with insomnia were the use of psychostimulants. A history of diabetes and insomnia were risk factors associated with sleep apnoea syndrome. Conclusion: The prevalence of sleep disturbance and insomnia among the respondents were 52.2% and 33.6% respectively. Use of psychostimulants was the identified risk factor. The prevalence of SAS was 4.72%, with diabetes and insomnia as associated factors.

关键词： Sleep Disorders Sleep Apnoea occupational health Burkina

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occupational health Hazards among Large-Scale Gold Mineworkers in Ghana

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occupational Diseases and Environmental Medicine 2022年第3期10卷 149-166页

作者： Emmanuel Dartey Isaac Monney Kofi Sarpong Collins Kuffour Department of Chemistry Education Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development Mampong Ashanti Ghana Department of Environmental health and Sanitation Education Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development Mampong Ashanti Ghana

Introduction: The mining industry ranks among the most hazardous occupations globally owing to the high prevalence of workplace accidents. To better protect workers in the industry, there is a need for a comprehensive understanding of risk factors, common illnesses and provision of PPE. Objective: This study examined the prevalence and underlying risk factors to work-related injuries, common illnesses, and Personal Protective Equipment (PPE) usage among mineworkers in two large-scale mining companies in Ghana that consented to participation. Methodology: Two hundred mineworkers were selected through stratified sampling in these companies using a semi-structured questionnaire. Chi-square test and binomial logistic regression were employed to determine the relationship between the incidence of occupational injury and selected risk factors using R studio. Results: The results showed that more than a tenth (16%;n = 31) of mineworkers had sustained physical injuries since being employed—mostly lacerations (53%). Out of those injured, (85%;n = 22) reportedly sustain an injury annually. A little more than half (57%;n = 112) of the mineworkers work for more than 40 hours per week. Injuries were significantly associated with the type of profession at the mine (p = 0.04;χ2 = 4.3)—Technicians and Mechanics were more likely to be injured. Although not statistically significant, working for more than 40 hours/week doubled the odds of being injured at the workplace (aOR = 1.77;95% CI: -0.27 - 1.48). The topmost illnesses among mineworkers were musculoskeletal pains (MSPs) [53%] and headaches (35%). About two-thirds (65%) had all the needed PPEs for their work. Safety goggles were the predominant PPE reportedly lacking among the mineworkers (16%;n = 31). Conclusion: There is a need for targeted training/intervention programmes and adoption of assistive ergonomic devices to protect mineworkers.

关键词： occupational health Safety Gold Mining Injury Illnesses Ghana

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Work Ability Index and Work Ability Score: A Comparation between both Scores in a Persistent COVID-19 Cohort

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occupational Diseases and Environmental Medicine 2024年第1期12卷 49-57页

作者： Carmen Muñoz-Ruiperez Diego Alvaredo Rodrigo Daniel Arroyo-Sánchez Juan Francisco Álvarez Zarallo Ignacio Sánchez-Arcilla Conejo José Lorenzo Bravo Grande Department of occupational health Hospital Universitario 12 de Octubre Madrid Spain Instituto de Investigación Biomédica Hospital 12 de Octubre (Imas12) Madrid Spain Department of occupational health Hospital Universitario Virgen Macarena Andalucía Sevilla Spain Department of occupational health Hospital Universitario Gregorio Mara&#241ón Madrid Spain Department of occupational health Complejo Asistencial Universitario de Salamanca Castilla y León Salamanca Spain

Aims: The present study aims to compare the assessment of work ability based on the use of the Work Ability Index (WAI) with another questionnaire base only on the use of WAI’s first item, termed as the “Work Ability Score” (WAS). Study design: A cohort of 384 Spanish workers included in a Post COVID-19 condition or persistent COVID-19 multicenter research was utilized. Place and Duration of Study: This cohort was enlisted in four hospitals (Hospital Universitario 12 de Octubre, Madrid;Hospital Universitario Virgen Macarena, Sevilla, Andalucía;Hospital Universitario Gregorio Marañón, Madrid and Complejo Asistencial Universitario de Salamanca, Castilla y León), since 2021 until 2022. Methodology: 384 Spanish workers (176 men and 208 women;aged 20 to 70 years) with Post COVID-19 condition or persistent COVID-19 were included. Descriptive analysis of primary scores was conducted. Given the non-normal distribution of data, the Mann-Whitney and Kruskal-Wallis tests were employed. Spearman and Kendall correlations were employed to assess the relationship between WAI and WAS, also used weighted Kappa to estimate the degree agreement between WAI and WAS. Logistic regression models were utilized to study determinants influencing WAI and WAS, categorized as poor or moderate. Results: WAI had an average score of 32.98 (SD = 10.28), whereas WAS had an average of 5.95 (SD = 2.77). Significant differences were observed in both WAI and WAS across the same variables. Strong and statistically significant correlations were evident between WAI and WAS (rs = 0.83, p < 0.001). All the variables used in the logistic regression model (gender, the sector employment, and previous chronic diseases) were statistically significant in both questionnaires. Conclusion: WAS questionnaire could be used as a tool for reliable assessment of work ability among Spanish workers with Post COVID-19 condition or Persistent CO-VID-19.

关键词： Work Ability Index Work Ability Score Post COVID-19 Condition occupational health occupational Medicine

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A nurse-led occupational health promotion program for farmers

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Journal of Integrative Nursing 2022年第4期4卷 251-254页

作者： Indrakshi BASU Rajadurai PREMAVATHY Smritikana MANI Department of Nursing Rani Meyyammai College of NursingAnnamalai UniversityChidambaramTamil NaduIndia Officer on Special Duty Nursing BranchGovernment of West BengalWest BengalIndia

Agrarian occupational health is a neglected primary health-care service in India.A nurse-led health promotion program is planned based on a Conceptual Model for the occupational health Nurse Specialist prepared by Ms.Janice Dees(1984)inspired from Orem’s self-care theory.The interventions included are range of motion exercise,progressive muscle relaxation technique,foot and palm massage,and literacy on safety practices.The wellness of field farmers is expected by following this program plan.

关键词： Field farmers health problems health promotion program nurse occupational health

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Evaluation of Attitudes of Family Physicians toward occupational health and occupational Diseases in Türkiye

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health 2023年第4期15卷 367-378页

作者： Gökmen Özceylan Giray Kolcu Ayse Coskun Beyan Department of Family Medicine Tekirdağ DrİFC State Hospital Tekirdağ Türkiye Department of Medical Education Suleyman Demirel University Isparta Türkiye Süleyman Demirel University Institute of Health Sciences Isparta Türkiye Department of occupational Medicine Dokuz Eylul University Faculty of Medicine Izmir Türkiye

Background/Aim: This study evaluated family physicians’ attitudes toward occupational health and disease in Türkiye. Materials and Methods: The study is cross-sectional and descriptive in a quantitative research design. The “Attitude Scale for Physicians toward occupational health and occupational Diseases” developed by Kolcu et al. was used in the study (Cronbach’s α 0.94). Our study aimed to sample the entire country using the stratified sample selection based on geographical region. 349 family physicians were included in the study according to sample size (n: 349). Results: The mean age of the participants in the study was 37.77 ± 8.96 (min: 27, max: 65 years). Of the participants, 65.2% were male. Of the physicians, 33.8% were family medicine specialists, and 38.8% had occupational physician certificates. It was determined that the level of attitude of family physicians toward occupational diseases was insufficient. It was also found that awareness increased as age increased, and awareness and attitude levels did not change according to gender. No significant difference was found in the scale total scores and subdimensions of family physicians’ occupational health and occupational disease attitudes according to the regions they worked in Türkiye. Conclusion: It has been concluded that there is no difference in awareness among family physicians in regions where it is much more important to diagnose an occupational disease, especially in industrial regions. The number of family physicians with occupational physician certificates was very insufficient, and a significant number of those who had occupational physician certificates did not practice occupational medicine.

关键词： Family Medicine occupational health occupational Disease Attitude Scale

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The Relationship of occupational health Nurses’ Experiences with Associated Departments in Relation to Project Development of Mental health Care for Primary Preventive Treatment

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Open Journal of Nursing 2023年第11期13卷 786-799页

作者： Yukiko Mochizuki Department of Public health Nursing Faculty of Nursing Toho University Tokyo Japan

Purpose: The purpose of this study was to clarify the relationship and experiences of occupational health nurses (OHNs) and related departments in project development of mental health care for primary treatment in the Japanese occupational health setting. Method: A total of 235 OHNs who are members of the Japan Academy of occupational health Nursing were sent an anonymous self-administered questionnaire survey. The questionnaire included items on the following: the OHN’s background, whether the OHN had experience in project development, the communication between the associated departments, the Japanese version of the Work Engagement Scale (UWES-J), occupational assessments, workplace assessments, and the Transtheoretical Model (TTM) for health promotion in companies and the OHN’s working environment. We performed logistic regression analysis to examine the relationship between experience and these harmonious relationships with other associated departments. Result: Responses from 61 OHNs (valid response rate: 25.9%) were analyzed. The mean number of years of service as an OHN was 18.9, and 82% of respondents had experience in project development. The logistic analysis further revealed that OHNs who had experience in project development of mental health care usually had a harmonious relationship with other associated departments. Conclusion: To promote mental health care for workers, OHNs have the capability to create individual and workplace assessments, enhance their work engagement, and make further improvements to their working environment. .

关键词： occupational health Mental health Care Experience in Project Development of Mental health Care occupational health Nurses

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occupational health with Emphasis on Muscle Load Assessment Using Objective and Subjective Assessment Techniques

Occupational Health with Emphasis on Muscle Load Assessment ...

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作者：巴特龙（Batloung Ramokepa）华中科技大学

学位级别：硕士

Objective The purpose was to learn occupational health practice in China, through participating in thelocal health surveillance work. Methods Visiting the Wuhan Institute of occupational Disease Prevention an... 详细信息

关键词： occupational health field investigation workplace assessment musculoskeletal disorders

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Knowledge, Practices, and Environmental and occupational health Risks Associated with Electronic Waste Recycling in Cotonou, Benin

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occupational Diseases and Environmental Medicine 2021年第2期9卷 33-48页

作者： M. G. Karel Houessionon Niladri Basu Catherine Bouland N. Marius Kedote Benjamin Fayomi N. Julius Fobil Edgard-Marius Ouendo Regional Institute of Public health Comlan Alfred Quenum University of Abomey-Calavi Ouidah Benin Department of Natural Resource Sciences McGill University Montreal Quebec Canada School of Public health Université Libre de Brussels Bruxelles Belgium Occupationnal health and Environment Research Unit University of Abomey-Calavi Cotonou Benin School of Public health University of Ghana Accra Ghana

Objective: The e-waste recycling is increasing worldwide, yet there remain outstanding environmental and occupational health concerns. Most research conducted on e-waste recycling has focused on only few countries (e.g., China, Ghana), thus there is a need to increase understanding of e-waste workers’ (recyclers’) knowledge and practices in other locations, that is purpose of this study. Methods: In a cross-sectional study conducted in Cotonou, Benin, 45 e-waste recyclers were interviewed from September to November 2018. Survey data was collected concerning their demographics, professional practices, and knowledge of occupational and environmental risks associated with e-waste recycling. Results: Most participants reported the following methods of material recovery of electronic items in declining orders: dismantling (97.8%) > sorting (91.1%) > incinerating (88.9%). Only 44.2% of the recyclers reported wearing ≥ 1 piece of personal protective equipment (PPE). More than 90% of e-waste workers noted that they disposed the e-waste in natural sites. About half, 46.7% believed that e-waste can pollute water and 71.1% considered that it can pollute air and soil. Recyclers reported several diseases including respiratory (67.4%), heart (62.8%), eye (65.1%), kidney (41.9%) and cancers (30.2%) could be linked to their work, respectively. Interestingly, we also found associations between the number of electronic items dismantled per month and self-report symptoms from the e-waste recyclers such as finding blood in urine and stool, wounds, dizziness, and itchy skin. Our results also indicated associations between the number of hours worked per day and blood in urine, dizziness, itchy skin and airway obstruction. Conclusion: To our knowledge this is the first study to interview e-waste workers in Benin. Doing this increase understanding of their work practices and knowledge to help inform intervention and prevention activities.

关键词： E-Waste Recycling occupational health Environment Knowledge Practice

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Sustainable Development Importance in Higher Education for occupational health and Safety Using Egypt Vision 2030 under COVID-19 Pandemic

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Journal of Geoscience and Environment Protection 2021年第4期9卷 74-112页

作者： Tarek Adel Mouneer Mechanical Engineering Department Benha Faculty of Engineering Benha University Benha Egypt

Insertion of Sustainable Development Goals (SDGs) into higher education is an important concern. This article aims to address the influences of SDGs in higher and engineering educational system in Egypt. The present study focuses on SDGs 3, 4, 6, 7, 9, and 11. SDG 3 is related to occupational health and SDG 4 is related to higher education development. However, SDGs 6, 7, 9, and 11 are related to both mechanical and environmental engineering, and occupational safety. The study approach involves case risk analysis, investigations, and review for design concepts of occupational health and safety before and after the Coronavirus disease (COVID-19). A number of cross-sectional studies that constitute 125 multidisciplinary research plans (MDRPs) are grouped to monitor and evaluate two main factors which are an influence of involving SDGs into engineering education and selected curriculum of occupational health and safety. Then the results of these research-based studies, which performed over four academic years started from 2017 up to date 2021, are depicted and discussed. These results reveal the importance of interlink between engineering education and the intended SDGs. The latest 25 MDRPs demonstrate that Egypt response to alleviate the COVID-19 is rapidly pronounced specially on SDGs 3 and 4 simultaneously. However, those MDRPs show that neither record impacts nor delays on SDGs 6, 7, 9 and 11. The conclusions prioritize both the advanced educational mechanisms and verify the engineering curriculums to raise awareness of SDGs among both staff members and students in Egyptian universities. Finally, future work is recommended at the end of this article to focus on each specific goal to gain deep insight to state of the art for each SDG around globe using education development.

关键词： Sustainable Development Education Development occupational Safety occupational health Egypt Vision 2030 COVID-19 Pandemic

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