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Clinicopathological features,psychological status,and prognosis of 33 patients with occult breast cancer

World Journal of Psychiatry 2024年第1期14卷 76-87页

作者： Hong-Mei Wang Ao-Yang Yu Lin-Lin Li Lu-Yao Ma Meng-Han Cao Yu-Le Yang Xiao-Bing Qin Juan-JuanTang Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Graduate School Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Pathology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND occult breast cancer(OBC)has traditionally been considered to be a carcinoma of unknown primary origin with a favorable prognosis and can be treated as stage II-III breast *** to the small number of cases and limited clinical experience,treatments vary greatly around the world and no standardized treatment has yet been *** To investigate the clinicopathological features,psychological status and prognostic features of patients with *** The clinicopathological data of 33 OBC patients diagnosed and treated in the Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital from November 2015 to November 2022 were retrospectively *** psychological status of OBC patients was evaluated by the Self-rating Anxiety Scale and Self-rating Depression ***’emotions,stress perception and psychological resilience were evaluated by the Positive and Negative Affect Schedule,the Chinese Perceived Stress Scale,and the Connor-Davidson Resilience Scale(CD-RISC),*** survival was calculated using the Kaplan-Meier method,and survival curves were plotted for analysis with the log-rank *** and multivariate survival analyses were performed using the Cox regression *** The 33 OBC patients included 32 females and 1 *** the 33 patients,30(91%)had axillary tumors,3(9%)had a neck mass as the primary symptom;18(54.5%)had estrogen receptor-positive tumors,17(51.5%)had progesterone receptor-positive tumors,and 18(54.5%)had Her-2-positive tumors;24(72.7%)received surgical treatment,including 18 patients who underwent modified radical mastectomy,1 patient who underwent breast-conserving surgery plus axillary lymph node dissection(ALND),and 5 patients who underwent ALND alone;12 patients received preoperative neoadjuvant *** 30 patients developed anxiety and depression,with low positive affect scores and high negative affect scores,accompanied by a high stress level and poor psycho

关键词： occult breast cancer breast cancer Perceived Stress Scale Axillary lymph node dissection

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Intratumoral heterogeneity of HER2 gene amplification in occult breast cancer

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Chinese Medical Journal 2014年第20期127卷 3676-3677页

作者： Xin Ling Zhang Hong Zhang Shuang Ye Jingming Li Ting Liu Yinhua breast Disease Center Peking University First Hospital Beljing100034 China

occult breast cancer （OBC） is an uncommon type of breast cancer, with palpable masses in the axillary area as the initial symptom. We report a case of OBC with HER2 genetic heterogeneity and discuss the impact of an unusual HER2 amplification pattern.A 56-year-old female was discovered a palpable mass in the right axillary area. She underwent a lymph node excisional biopsy at another hospital approximately one month before referral to our hospital service for further evaluation. The biopsy showed lymph tissue with tumor cell infiltrating in the form of sheets or nests. The tumor cells were larging in size, obviously atypical, and showed prominent nucleoli and intracellular keratosis. Mammography, chest X-ray, chest computed tomography （CT）, abdominal ultrasonography （US）, and positron emission tomography- CT （PET-CT）, which were also performed at the initial hospital, showed no abnormal findings.

关键词： breast neoplasm occult breast cancer HER2 genetic heterogeneity

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Application of neoadjuvant chemotherapy combined with anlotinib in occult breast cancer:A case report and review of literature

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World Journal of Clinical Cases 2021年第4期9卷 919-926页

作者： Yu Zhang Di Wu Bo Zhao Xue-Liang Tian Tian-Cheng Yao Feng Li Wei-Fang Liu Ai-Ping Shi Department of breast Surgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND occult breast cancer(OBC)is a special type of breast cancer presenting as axillary lymph node metastasis with undetectable primary lesions in the *** to its low incidence and unique clinical manifestations,there is a lack of consensus on the diagnosis and treatment of *** report a case of OBC treated with neoadjuvant chemotherapy combined with *** treatment was well tolerated,and the patient achieved a pathologic complete *** SUMMARY A 53-year-old woman presented with a lump in her right axillary area with no primary lesions in the *** biopsy confirmed right axillary metastatic *** staining results were positive for progesterone receptor,cytokeratin 7,specific breast markers GATA3 and gross cystic disease fluid *** cells were negative for estrogen receptor,human epidermal growth factor receptor-2,cytokeratin 5/6,cytokeratin 20,and *** patient was diagnosed with OBC,and she underwent neoadjuvant chemotherapy combined with *** plus axillary lymph node dissection was *** patient achieved pathologic complete response with no residual invasive tumor cells in the breast or axillary lymph ***,she received adjuvant radiotherapy and endocrine *** Neoadjuvant chemotherapy and anlotinib had good efficacy and safety in the treatment of OBC and may be a new therapeutic option.

关键词： occult breast cancer Neoadjuvant chemotherapy Anlotinib Mastectomy Pathological complete response Case report

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Presentation of Axillary Metastases from occult breast Carcinoma

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Chinese Journal of Clinical Oncology 2007年第1期4卷 1-5页

作者： Xin Wang First Department of breast Tumor TianjinMedical University Cancer institute and Hospital Tianjin 300060 China.

Axillary presentation from occult breast cancer is uncommon and continues to be a diagnostic and therapeutic challenge to physicians. Once the diagnosis of adenocarcinoma metastatic to an axillary lymph node has been confi rmed, a preoperative workup should be done. The current experience is based on several relatively small retrospective reviews and case reports. It is diffi cult to determine the best management of occult breast cancer. However, treatment of axillary lymph node dissection is recommended for local control and complete staging information. Treatment of breast should be a choice between breast conservation with whole-breast radiotherapy and mastectomy. Adjuvant systemic treatment should be offered.

关键词： occult breast cancer axiUary metastases mastectomy breast conservation radiotherapy.

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Tumor-Specific Histo-Blood Group Antigens: Apropos of Two Cases

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Case Reports in Clinical Medicine 2023年第7期12卷 232-250页

作者： Ferenc Baranyay Department of Pathology Kanizsai Dorottya Hospital Nagykanizsa Hungary

cancer cells with immunogenic properties having altered protein glycosylation, modified blood group substances have been widely studied. Due to the genetic instability occurring during carcinogenesis the glycosyltransferases may suffer from posttranslation sequence modification. The author describes 2 autopsy cases, where in the background of the unusual metastatic tumor presentation, incompatible blood group antigenic determinants have been demonstrated using blood group specific lectins and monoclonal antibodies (mAb). In the first case, reported here, a 10-year-old girl developed an acute myeloid leukemia and died in a septic endotoxin shock after successful cytostatic treatment of a juvenile signet ring cell cancer of her colon. At autopsy there were no signs of tumor except bilateral apple-sized mucinous ovarian (Krukenberg) metastases. While she had erythrocyte phenotype of blood group A, the signet ring adenocarcinoma cells expressed blood group B incompatible antigenic determinants with lectin/mAb. In the second case, the autopsy of a 78-year-old female resulted in no macroscopic tumor sign except a moderately enlarged, ham hard spleen. Light microscopy revealed adenocarcinomatous infiltration in the splenic sinusoids. The patient had blood group O, while the metastatic cells in the spleen reacted with breast Carcinoma Antigen (BioGenex) and incompatible anti-B Banderiaeasimplicifolia agglutinin I and anti-B mAb. It proved to be a case of an occult, completely regressed breast cancer. Based on these observations the expression of tumor specific incompatible blood group antigens might occur from time to time, mostly in adenocarcinomas. Accordingly, blood group-based specific immuno-oncotherapy could be considered in some cancer cases.

关键词： occult breast cancer Krukenberg Metastasis Incompatible Tumor-Specific Histo-Blood Group Antigens

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