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nuclear transcription factors and lipid homeostasis in liver

Chinese Medical Journal 2007年第24期120卷 2290-2296页

作者： CHEN Ya-xi HUANG Ai-long RUAN Xiong-zhong Centre for Lipid Research,Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China(Chen YX,Huang AL and Ruan XZ) Centre for Lipid Research Key Laboratory of Molecular Biology on Infectious DiseasesMinistry of Education

The liver plays a major role in the regulation , glucose, lipid and energy metabolism. Increasd hepatic fat deposit is a very common feature in obese, insulin-resistant patients, in metabolic syndrome, alcoholic steatohepatitis （ASH） and nonalchoholic fatty liver disaseas （NAFLD）. As a central organ for whole body lipid metabolism, disruption of the normal mechanisms for synthesis, transport and removal/ metabolism of long-chain fatty acids and triglycerides are the basis for the development of fatty liver. The exact mechanisms that link hepatic lipid accumulation, impaired glucose metabolism, and insulin resistance are unknown, but increasing evidence suggest that nuclear transcription factors play important roles. Members of the nuclear receptor superfamily, especially the peroxisome proliferator-activated receptors （PPARs） and the liver X receptor （LXR）, other factors such as sterol regulatory element binding proteins （SREBPs）, carbohydrate- response element-binding protein （ChREBP）, and nuclear transcription fator-κB （NF-κB） have emerged as dominant regulators of these processes, but the relative role of each of these factors in fatty liver disease is still undefined.

关键词： nuclear transcription factors lipid homeostasis fatty liver

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Effects of oridonin on nuclear transcription factors and its target genes related inflammatory factors in human BxPC-3 cells

Effects of oridonin on nuclear transcription factors and its...

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第九届全国免疫学学术大会

作者： Ru-Yi Chen Jian Xu The College of Life Science Zhejiang Chinese Medical University

Objective:To investigate the effects of ondonin on nuclear transcription factors and the relationship of which target genes with inflammatory factors in human BxPC-3 ***:BxPC-3 cells were treated with different concentrations of oridonin,and it viability curve were used to test the inhibition effect of oridonin on the BxPC-3 *** expression of cytokines in the BxPC-3 cells supernatant was detected by ELISA and the protein expression of nuclear transcription factors,such as NF-κB,AP-1,IL-33,STAT3,and Smads,and its taget gene proteins,like Survivin,VEGF,and MMP-2,in the BxPC-3 cells was detected by western blot and immunonuorescent ***:The viability curve of BxpC-3 cells treatment with oridonin exhibited a dose-dependent *** analysis revealed that oridonin can down-regulate the inflammation factor(IL-1β,IL-6,IL-33)in a dose-dependent *** blot,and immunonuorescent staining analysis suggested that oridonin can regulate proteins expression of the nuclear transcription factors(NF-κB,IL-33,AP-1,STAT3,Smads),and influenced corresponding inflammatory factors expression which related target ***:The results suggested that oridonin against the pancreatic cancer maybe by regulating the nuclear transcription factors and its targeted inflammatory factors.

关键词： Pancreatic cancer nuclear transcription factors inflammation factors

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Effect of oridonin-mediated hallmark changes on inflammatory pathways in human pancreatic cancer(BxPC-3) cells

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World Journal of Gastroenterology 2014年第40期20卷 14895-14903页

作者： Ru-Yi Chen Bin Xu Su-Feng Chen Si-Si Chen Ting Zhang Jun Ren Jian Xu The College of Life Science Zhejiang Chinese Medical University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

AIM: To investigate the effect of oridonin on nuclear transcription factors and to study the relationship between biological behavior and inflammatory factors in human pancreatic cancer (BxPC-3) cells.

关键词： Pancreatic cancer Hallmarks Oridonin Inflammatory pathways nuclear transcription factors

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