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Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype

burns & Trauma 2022年第1期10卷 33-47页

作者： Shiyan Li Ping Yang Xiaofeng Ding Hao Zhang Youjun Ding Qian Tan Department of burns and Plastic Surgery Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNO.321Zhongshan RoadNanjingJiangsuChina Department of burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNO.321Zhongshan RoadNanjingJiangsu 210008China Department of burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical College of Jiangsu UniversityNO.321Zhongshan RoadNanjingJiangsu 210008China Department of burns and Plastic Surgery Anqing Shihua HospitalNanjing Drum Tower Hospital GroupAnqing 246002China

background:Skin wound healing depends on the progress of different but overlapping stages of healing,including hemostasis,inflammatory,proliferative and *** of these stages to occur in a timely and gradual manner may result in non-healing pathological *** and neutrophils have been shown to play an essential role in the inflammatory responses of wound tissue,and their active plasticity allows them to modulate tissue damage and repair *** ability of macrophages and neutrophils to regulate the occurrence and resolution of inflammatory processes is essential for the treatment of pathological wound ***:Mice were categorized into negative control,streptozotocin,streptozotocin+puerarin and puerarin *** traditional Chinese medicine extract puerarin was selected to treat different groups of mice with a full-thickness skin defect *** of the RAW264.7 cell line were stimulated under different puerarin ***,real time quantitative polymerase chain reaction(RT-qPCR),western blot,immunofluorescence and other assays were carried out to explore the effect of puerarin on wound healing and its molecular ***:Animal experiments found that the wound healing of diabetic mice treated with puerarin was significantly accelerated,and histological analysis found that puerarin treatment markedly decreased the infiltration of macrophages and neutrophils in wound *** western blot,RT-qPCR and immunofluorescence experiments,it was observed that puerarin treatment remarkably inhibited nuclear factor kinase b(NF-κb)and mitogen-activated protein kinase(MAPK)signaling pathways,downregulated the expression of inflammatory cytokines and induced the M2 polarization of *** the cellular level,we also observed that puerarin improved M2 macrophage polarization and inhibited inflammatory pathway activation in a high-glucose ***:Puerarin has a significant therapeutic effect on wound he

关键词： Macrophage Puerarin Wound healing Diabetes Skin Streptozotocin Traditional Chinese medicine nuclear factor kinase b Mitogen-activated protein kinase

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