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novel action of 3,4-daa ameliorating acute liver allograft injury

Novel Action of 3,4-DAA ameliorating Acute Liver Allograft I...

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2012年浙江省医学会肝病、感染病学学术年会暨浙江省感染科医师学术年会

作者： Qing-Feng Sun Ji-Guang Ding Ji-Fang Sheng Man-Hua Zhu Jun-Jie Li Zi-Ke Sheng Xiao-Feng Tang Department of Infectious Diseases the Third Affiliated Hospital to Wenzhou Medical College Department of infectious diseases The First Affiliated Hospital to Medical College of Zhejiang University Department of Surgery The First Affiliated Hospital to Medical College of Zhejiang University

The anti-allergic drug,N-(3,4-dimethoxycinnamonyl) anthranilic acid(3,4-daa),is a synthetic anthranilic acid derivative that has been used therapeutically in Japan for many *** this study,to investigate the effects of 3,4-daa in allograft immunorejection model,liver orthotopic transplants were performed using inbred male Dark Agouti donors and Lewis rat recipients(allografts).The levels of indoleamine 2,3-dioxygenases (IDO) enzymic activities in four groups,allografts(control),DMSO-treated group(vehicle control),200 mg/kg/day 3,4-daa-treated group and 200 mg/kg/day 3,4-daa+5mg/ml 1-Methyl-D-tryptophan(1-MT)-treated group were confirmed by determination of L-kynurenine(L-Kyn) *** serum alanine aminotransferase(ALT) levels in 3,4-daa-treated rats significantly decreased compared with those in mock and control group while treatment of 1-MT in allografts led to the opposite *** of 3,4-daa reduced histological severity of allograft immunorejection,decreased serum levels of cytokines tumor necrosis factor-alpha(TNF-α) and interferon-gamma(IFN-γ),and raised serum levels of interleukin-10(IL-10), suggesting 3,4-daa has both anti-inflammatory and anti-immunorejection properties through IDO in immune regulation,and may therefore be useful in filling an unmet need,in the treatment of allograft immunorejection.

关键词： daa action novel action of 3,4-daa ameliorating acute liver allograft injury

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novel action of 3,4-daa ameliorating acute liver allograft injury

Novel Action of 3,4-DAA ameliorating Acute Liver Allograft I...

引用

第四届中国医师协会感染科医师大会暨传染病诊治高峰论坛、浙江省医学会肝病、感染病学学术年会

作者： Department of Infectious Diseases,the Third Affiliated Hospital to Wenzhou Medical College,Rui' an,Zhejiang,325200,China Qing-Feng Sun Ji-Guang Ding Department of infectious diseases,The First Affiliated Hospital to Medical College of Zhejiang University,Hangzhou,Zhejiang,310003,China Ji-Fang Sheng Man-Hua Zhu Jun-Jie Li Zi-Ke Sheng Department of Surgery,The First Affiliated Hospital to Medical College of Zhejiang University,Hangzhou,Zhejiang,310003,China Xiao-Feng Tang

The anti-allergic drug,N-(3,4-dimethoxycinnamonyl) anthranilic acid(3,4-daa),is a synthetic anthranilic acid derivative that has been used therapeutically in Japan for many *** this study,to investigate the effects of 3,4-daa in allograft immunorejection model,liver orthotopic transplants were performed using inbred male Dark Agouti donors and Lewis rat recipients(allografts).The levels of indoleamine 2,3-dioxygenases (IDO) enzymic activities in five groups,allografts(control),DMSO-treated group(vehicle control),200 mg/kg/day 3,4-daa-treated group and 200 mg/kg/day 3,4-daa+5mg/ml 1-Methyl-D-tryptophan(1-MT)treated group were confirmed by determination of L-kynurenine(L-Kyn) *** serum alanine aminotransferase(ALT) levels in 3,4-daa-treated rats significantly decreased compared with those in mock and control group while treatment of 1 -MT in allografts led to the opposite *** of 3,4-daa reduced histological severity of allograft immunorejection,decreased serum levels of cytokines tumor necrosis factor-alpha(TNF-α) and interferon-gamma(IFN-γ),and raised serum levels of interleukin-10(IL-10), suggesting 3,4-daa has both anti-inflammatory and anti-immunorejection properties through IDO in immune regulation,and may therefore be useful in filling an unmet need,in the treatment of allograft immunorejection.

关键词： daa novel action of 3,4-daa ameliorating acute liver allograft injury action

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