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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1842-1847页

作者： Hui Xiao Xiao-Yu Xu Yi-Min Zhong Xing Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sun University

AIM： To investigate the variation in the central lamina cribrosa thickness（cLCT）, and the central anterior lamina cribrosa surface depth（cALCSD）, as well as the central prelaminar tissue thickness（cPLTT） related to age in healthy Chinese ***： A total of 96 eyes from 96 Chinese healthy subjects were recruited. According to age, the 96 cases were divided into three groups： the young group（YG, 18-39 y）, middle-age group（MG, 40-59 y） and older-age group（OG, 60 y and above）. Lamina cribrosa images were obtained from all participants using radial linear protocol by enhanced depth imaging spectral-domain optical coherence tomography. The cLCT, cALCSD and cPLTT were calculated from the average value of the lamina cribrosa thickness, anterior lamina cribrosa surface depth and prelaminar tissue thickness in the optic nerve head（ONH） centre point and paracentral points（150 μm from the centre point in the horizontal and vertical directions）. RESULTS： For the total subjects, the mean cLCT, c ALCSD and cPLTT were 235.18±41.27, 358.02±93.80 and 182.02±92.11 μm, respectively. No statistically significant differences in cLCT, cALCSD or cPLTT were found between gender and different eyes（P=0.27-0.92）. The cLCT of the OG was the thickest among the three groups, while the c PLTT of the YG was the thickest among the three groups（P〈0.05）. Age was positively correlated with cLCT（r=0.42, P〈0.001）, and negatively correlated with cPLTT（r=-0.24, P=0.02）. No significant correlation was found between the age and cALCSD（r=-0.06, P=0.55）. And no correlation has been found between axial length and cLCT, cALCSD and c PLTT（P=0.11-0.81）.CONCLUSION： The impact of age on the cLCT and the cPLLTT should be taken into account when analysing glaucoma and other diseases related to lamina cribrosa.

关键词： lamina cribrosa thickness normal subjects optical coherence tomography age

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The Study of Retinal Nerve Fiber Layer Thickness of normal Eyes Using Scanning Laser Polarimetry

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眼科学报 2006年第3期22卷 175-183页

作者： Xing Liu Jingjing Huang Jian Ge Yunlan Ling Xiaoping Zheng Key Laboratory of Ophthalrnology of the Ministry of Education and Zhongshan OphthalmicCenter Sun Yat-sen University Guangzhou 510060 China

Purpoe: To evaluate retinal nerve fiber layer (RNFL) thickness measurements in local normal Chinese subjects of different age groups and analyse the correlation of RNFL thickness with age using scanning laser polarimetry (SLP,GDxVCC). To assess the reproducibility of RNFL thickness measurement with GDxVCC. Methods: The RNFL thickness of 67 normal subjects (123 eyes) were measured by GDxVCC. The average TSNIT parameters were calculated. The differences of RNFL thickness between sex,right and left eyes,superior and inferior were compared. The relationship between RNFL thickness and age was analyzed with correlation analysis and linear regression analysis. The intraclass correlation coefficients (ICC) of three images in every eye were calculated. Results: The average peripapillary RNFL thickness at the superior,inferior and whole ellipse regions in 123 eyes of 67 normal subjects were (70.30±6.76)(?)m,(67.35±6.77)(?)m and (56.87±4.53)(?) m,respectively. The average TNSIT standard deviation was 23.68±4.61 and the average inter-eye symmetric value was 0.86±0.11. There were significant difference of RNFL thickness between superior and inferior (t=4.952,P subjects aged below 60 years old. The ICC values of RNFL thickness were >0.8 in superior,inferior and global. Conclusions: The RNFL thickness can be measured accurately by GDxVCC and the reproducibility of RNFL thickness measurement by GDxVCC is good. There was a slight negative correlation between average RNF

关键词： Scanning laser polarimetry Retinal nerve fiber layer normal subjects

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