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A NOVEL ZWITTERIONIC SILANE COUPLING AGENT FOR nonthrombogenic biomaterials

Chinese Journal of Polymer Science 2005年第6期23卷 611-617页

作者： Yong-zhi Qiu Dou-yong Min Chi Ben Chi Ben Qiang Chen Si-cong Lin Research Center of Surface ＆ Interface Chemistry and Engineering Technology Nanjing University Nanjing 210093 China College of Chemistry ＆ Environment Science Nanjing Normal University Nanjing 210097 China

A novel silane coupling agent bearing sulfobetaine group, N,N-diethyl-N-（3-sulfopropyl）-aminopropyl- trimethoxysilane （DESATS）, was first designed, synthesized and characterized. Its solution property was studied by means of dynamic light scattering. DESATS was successfully bonded onto the surface of the glass and proved by ESCA. Platelet adhesion assay in vitro indicated that the nonthrombogenicity of glass slide modified with DESATS is greatly improved.

关键词： Zwitterionic silane coupling agent Silicone-sulfobetaine nonthrombogenic biomaterials

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MOLECULAR ENGINEERING STUDIES ON nonthrombogenic biomaterials——A NOVEL CLASS OF nonthrombogenic biomaterials WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES

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Chinese Journal of Polymer Science 2005年第1期23卷 93-102页

作者： JunZhou Yong-zhiQiu Xiao-pengZang Chang-wangPan QiangChen JianShen Si-congLin ResearchCenterofSurface＆InterfaceChemistryandEngineeringTechnology NanjingUniversityNanjing210093China

N,N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium(DMMCA)was graft-copolymerized onto thesurface of segmented poly(ether urethane)(SPEU)and PE *** carboxybetaine structure on SPEU and PE filmsurfaces was confirmed by ATR-FTIR,XPS and water contact angle *** the experiments with plateletadhesion and protein adhesion assay in vitro,the two materials studied,including poly-DMMCA gel,all show *** confirms once again that the zwitterionic molecular structure on the surfaces of materials isessential for improving their nonthrombogenicity and biocompatibility.

关键词： nonthrombogenic biomaterials Zwitterionic biomaterial Carboxybetaine structure Surface graftcopolymerization.

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GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY

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Chinese Journal of Polymer Science 2003年第4期21卷 419-426页

作者：林思聪 Research Center of Surface and Interface Chemical and Engineering Technology Nanjing University Nanjing 210093 China

On the molecular level, it is believed that polymers containing zwitterionic structures should be compatible withblood. In this work polyurethane films were grafted with sulfobetaine by a three-step procedure. In the first step, the films'surfaces were treated with hexamethylene diisocyanate (HDI) in toluene at 50℃ in the presence of di-n-butyl tin dilaurate(DBTDL) as a catalyst. The extent of the reaction was monitored by ATR-IR spectra; a maximum number of free NCOgroups was obtained after a reaction time of 90 min. In the second step, the hydroxyl groups of N,N-dimethylethylethanolamine (DMEA) were allowed to react in toluene with NCO groups bound on the surface. In the thirdstep, sulfobetaines were formed on the surface through the ring-opening reaction between tertiary amine of DMEA and 1,3-propanesultone (PS). The surfaces of the films were characterized by ATR-IR and XPS showing that the grafted surfaceswere composed of sulfobetaine. The results of the contact angle measurement show that the surface was strongly *** platelet adhesion test demonstrated that the films grafted with sulfobetaine have excellent blood compatibility.

关键词： Polyurethane Sulfobetaine Surface modification Platelet adhesion nonthrombogenic biomaterials

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