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β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study

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World Journal of Hepatology 2022年第2期14卷 429-441页

作者： Sameh A Lashen Mohammed M Shamseya Marwa A Madkour Radwa M Abdel Salam Sanaa S Mostafa Division of Hepatology and Gastroenterology Faculty of MedicineAlexandria UniversityAlexandria 21521Egypt Department of Experimental and Clinical Internal Medicine Medical Research InstituteAlexandria 21561Egypt Department of Pathology Medical Research InstituteAlexandria UniversityAlexandria 21561Egypt

BACKGROUND Portal hypertension,a common complication associated with liver cirrhosis,can result in variceal bleeding,which greatly impacts patient ***,β-arrestin-2 has been shown to predict the acute hemodynamic response to nonselectiveβ-blocker therapy for cirrhotic portal ***,more data is needed on the long-term effects of and changes inβ-arrestin-2 following nonselectiveβ-blocker *** To investigate the expression and role ofβ-Arrestin-2 in predicting the long-term response to nonselectiveβ-blockers in cirrhotic portal hypertensive *** We prospectively enrolled 91 treatment-naïve patients with cirrhotic portal *** clinical and laboratory data were *** was performed for grading and treating varices and obtaining gastric antral *** measured the serum and antral expression ofβ-arrestin-2 and obtained Doppler measurement of the portal vein congestion *** with nonselectiveβ-blockers was then *** patients were followed up for 18 mo,after which they have undergone a repeat antral biopsy and re-evaluation of the portal vein congestion *** A higher serum level and antral expression ofβ-arrestin-2 was associated with longer bleedingfree intervals,greater reduction in the portal vein congestion index,and improved grade of *** patients with a lowβ-arrestin-2 expression,17.6%were nonselectiveβ-blocker responders,whereas,among those with high expression,95.1%were responders(Pnonselectiveβ-blocker ***β-arrestin-2 expression in cirrhotic portal hypertension predicts the clinical response to long-term nonselectiveβ-blocker ***β-arrestin-2 is a potential noninvasive biomarker for selecting the candidate patients for nonselectiveβ-bl

关键词： β-arrestin-2 Portal hypertension Variceal bleeding nonselective beta-blockers Portal congestion index Variceal ligation

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