检索结果-南通市图书馆

Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats

引用

World Journal of Gastroenterology 2020年第46期26卷 7299-7311页

作者： Li-Jun Xue Ju-Qiang Han Yuan-Chen Zhou Hong-Ye Peng Teng-Fei Yin Kai-Min Li Shu-Kun Yao School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China Department of Hepatology The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND nonalcoholic fatty liver disease(NAFLD)has become one of the most common chronic liver diseases in the *** our early clinical data and questionnaire analysis of NAFLD,it was found that the body mass index of some patients did not meet the diagnostic criteria for overweight or *** consumption of high-temperature-processed foods such as fried food,hot pot and barbecue is closely related to the occurrence of nonobese *** the intake of this kind of food can reduce disease severity and improve *** To explore the untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease in Sprague-Dawley rats induced by high-temperatureprocessed *** Fifty-four male Sprague-Dawley rats were divided into three groups:The control group received a standard diet;the nonfried soybeans(NDFS)group received 60%NDFS and 40%basic feed and the dry-fried soybeans(DFS)group received 60%DFS and 40%basic *** rats were sacrificed at week 4,8,and 12 in each *** food intake,body weight,Lee’s index,liver index,serological index and hepatic histopathology were *** metabolomics characteristics were used to analyze the changes in liver metabolites of rats at week *** between metabolites and pathology scores between the DFS and control groups and between the DFS and NDFS groups were *** selected some of the metabolites,both within the pathway and outside of the pathway,to explain preliminarily the difference in liver pathology in the three groups of *** There were no statistically significant differences in the food intake,body weight,Lee's index or serological index between the DFS group and the control group(P>0.05).At week 8 and week 12,the steatosis scores in the DFS group were significantly higher than those in the other two groups(Pliver index of the DFS group was the lowest(NDFS group vs DFS group,P<0.05).The fibrosis score in the DFS group was sign

关键词： nonobese nonalcoholic fatty liver disease High-temperature-processed feed Mild steatosis and early fibrosis Untargeted metabolomics characteristics Animal models Novel pathogenesis for nonalcoholic fatty liver disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：