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Ginsenoside Rg1 ameliorates bloodebrain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release

引用

Acta Pharmaceutica Sinica B 2021年第11期11卷 3493-3507页

作者： Kefeng Zhai Hong Duan Wei Wang Siyu Zhao Ghulam Jilany Khan Mengting Wang Yuhan Zhang Kiran Thakur Xuemei Fang Chao Wu Jianbo Xiao Zhaojun Wei Suzhou Engineering Research Center of Natural Medicine and Functional Food School of Biological and Food EngineeringSuzhou UniversitySuzhou 234000China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Department of Analytical Chemistry and Food Science Faculty of Food Science and TechnologyUniversity of Vigo-Ourense CampusOurense E-32004Spain School of Biological and Food Engineering Anhui Polytechnic UniversityWuhu 241000China Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University) Guilin 541004China Department of Pharmacology and Therapeutics Faculty of PharmacyUniversity of Central PunjabLahore 54000Pakistan

During the traumatic brain injury(TBI),improved expression of circulatory miR-21 serves as a diagnostic *** levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and bloodebrain barrier(BBB)permeability,reduce nerve apoptosis,restore neural function and ameliorate *** evaluated the role of macrophage derived exosomes-miR-21(M-Exos-miR-21)in disrupting BBB,deteriorating TBI,and Rg1 ***-1β-induced macrophages(ⅡA)-Exos-miR-21 can activate NF-kB signaling pathway and induce the expressions of MMP-1,-3 and-9 and downregulate the levels of tight junction proteins(TJPs)deteriorating the ***1 reduced miR-21-5 p content in ⅡA-Exos(RⅡA-Exos).The interaction of NMIIAe HSP90 controlled the release of Exos-miR-21,this interaction was restricted by ***1 could inhibit the Exos-miR-21 release in peripheral blood flow to brain,enhancing TIMP3 protein expression,MMPs proteolysis,and restricting TJPs degradation thus protected the BBB ***,Rg1 can improve the cerebrovascular endothelial injury and hold the therapeutic potential against TBI disease.

关键词： Traumatic brain injury Exosome MiRNA-21 Bloodebrain barrier Ginsenoside Rg1 nonmuscle myosinⅱa

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